Oleanolic acid and related triterpenoids from olives on vascular function: molecular mechanisms and therapeutic perspectives - PubMed (original) (raw)
Review
Oleanolic acid and related triterpenoids from olives on vascular function: molecular mechanisms and therapeutic perspectives
Rosalia Rodriguez-Rodriguez. Curr Med Chem. 2015.
Abstract
Oleanolic acid and related triterpenoids from olives modulate different signaling pathways, showing a wide range of pharmacological activities against inflammation, cancer or cardiovascular diseases. In particular, emerging evidences reveal the potential of oleanolic acid to restore vascular disorders associated to cardiovascular risk factors, i.e. hypertension, obesity and diabetes, and atherosclerosis. During the previous years, in vitro and in vivo studies with these triterpenoids have positioned them as being mainly responsible for cardiovascular risk protection traditionally associated to olive oil. This review updates recent investigations in olive oil triterpenoids function related to cardiovascular diseases, as well as the underlying mechanisms and structural implications. Important aspects of olive oil triterpenoids such as bioavailability and clinical perspectives on cardiovascular disorder are also extensively analyzed. All these investigations evidence the potential of triterpenoids from olive oil as a promising therapeutic strategy against vascular function, thus efficiently preventing the progression of cardiovascular diseases.
Similar articles
- Antihypertensive, antiatherosclerotic and antioxidant activity of triterpenoids isolated from Olea europaea, subspecies africana leaves.
Somova LI, Shode FO, Ramnanan P, Nadar A. Somova LI, et al. J Ethnopharmacol. 2003 Feb;84(2-3):299-305. doi: 10.1016/s0378-8741(02)00332-x. J Ethnopharmacol. 2003. PMID: 12648829 - Bioactive properties of the main triterpenes found in olives, virgin olive oil, and leaves of Olea europaea.
Sánchez-Quesada C, López-Biedma A, Warleta F, Campos M, Beltrán G, Gaforio JJ. Sánchez-Quesada C, et al. J Agric Food Chem. 2013 Dec 18;61(50):12173-82. doi: 10.1021/jf403154e. Epub 2013 Nov 22. J Agric Food Chem. 2013. PMID: 24279741 Review. - Oleanolic acid and ursolic acid: research perspectives.
Liu J. Liu J. J Ethnopharmacol. 2005 Aug 22;100(1-2):92-4. doi: 10.1016/j.jep.2005.05.024. J Ethnopharmacol. 2005. PMID: 15994040 Review. - Hypotensive Effects of the Triterpene Oleanolic Acid for Cardiovascular Prevention.
Sureda A, Monserrat-Mesquida M, Pinya S, Ferriol P, Tejada S. Sureda A, et al. Curr Mol Pharmacol. 2021;14(6):935-942. doi: 10.2174/1874467213999201230211544. Curr Mol Pharmacol. 2021. PMID: 33390142 Review. - New Applications of Oleanolic Acid and its Derivatives as Cardioprotective Agents: A Review of their Therapeutic Perspectives.
Sun N, Li D, Chen X, Wu P, Lu YJ, Hou N, Chen WH, Wong WL. Sun N, et al. Curr Pharm Des. 2019;25(35):3740-3750. doi: 10.2174/1381612825666191105112802. Curr Pharm Des. 2019. PMID: 31692428 Review.
Cited by
- In Silico and In Vitro Studies of Terpenes from the Fabaceae Family Using the Phenotypic Screening Model against the SARS-CoV-2 Virus.
de Sousa NF, Duarte GD, Moraes CB, Barbosa CG, Martin HJ, Muratov NN, Nascimento YMD, Scotti L, de Freitas-Júnior LHG, Filho JMB, Scotti MT. de Sousa NF, et al. Pharmaceutics. 2024 Jul 9;16(7):912. doi: 10.3390/pharmaceutics16070912. Pharmaceutics. 2024. PMID: 39065609 Free PMC article. - Multi-omics revealed rumen microbiota metabolism and host immune regulation in Tibetan sheep of different ages.
Sha Y, Liu X, He Y, Zhao S, Hu J, Wang J, Li W, Shao P, Wang F, Chen X, Yang W, Xie Z. Sha Y, et al. Front Microbiol. 2024 Feb 13;15:1339889. doi: 10.3389/fmicb.2024.1339889. eCollection 2024. Front Microbiol. 2024. PMID: 38414776 Free PMC article. - Effects of oleanolic acid administration on renal NF-kB, IL-18, IL-6, YKL-40, and KIM-1 in experimental diabetic rats.
Iskender H, Dokumacioglu E, Hayirli A, Kapakin KAT, Bolat I, Kirman EM. Iskender H, et al. Iran J Basic Med Sci. 2023;26(10):1188-1193. doi: 10.22038/IJBMS.2023.71321.15504. Iran J Basic Med Sci. 2023. PMID: 37736511 Free PMC article. - The Impact of Acute Low-Dose Gamma Irradiation on Biomass Accumulation and Secondary Metabolites Production in Cotinus coggygria Scop. and Fragaria × ananassa Duch. Red Callus Cultures.
Ciocan AG, Maximilian C, Mitoi EM, Moldovan RC, Neguț D, Iuga CA, Helepciuc FE, Holobiuc I, Radu M, Vassu Dimov T, Cogălniceanu G. Ciocan AG, et al. Metabolites. 2023 Jul 28;13(8):894. doi: 10.3390/metabo13080894. Metabolites. 2023. PMID: 37623838 Free PMC article. - OeBAS and CYP716C67 catalyze the biosynthesis of health-beneficial triterpenoids in olive (Olea europaea) fruits.
Alagna F, Reed J, Calderini O, Thimmappa R, Cultrera NGM, Cattivelli A, Tagliazucchi D, Mousavi S, Mariotti R, Osbourn A, Baldoni L. Alagna F, et al. New Phytol. 2023 Jun;238(5):2047-2063. doi: 10.1111/nph.18863. Epub 2023 Apr 3. New Phytol. 2023. PMID: 36880371 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources