Obesity-related immune responses and their impact on surgical outcomes - PubMed (original) (raw)
Review
doi: 10.1038/ijo.2015.21. Epub 2015 Feb 20.
Affiliations
- PMID: 25697667
- DOI: 10.1038/ijo.2015.21
Review
Obesity-related immune responses and their impact on surgical outcomes
M Quante et al. Int J Obes (Lond). 2015 Jun.
Abstract
The obesity epidemic represents a critical disease burden with broad clinical consequences. At the same time, obesity has been linked to inferior surgical outcomes and considered a contraindication for some elective surgical procedures. A growing body of mechanistic evidence has accumulated linking obesity to changes of metabolism and immune responses. This concept provides an integrated inflammatory network based on the perception of obesity as a state of chronic low-grade inflammation. With a more detailed understanding of this dynamic network and mechanistic insights, novel treatment and management strategies may be developed with the goal to optimize surgical outcomes in obese patients.
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