Tipping the metabolic scales towards increased longevity in mammals - PubMed (original) (raw)

Review

. 2015 Mar;17(3):196-203.

doi: 10.1038/ncb3107.

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• PMID: 25720959
• DOI: 10.1038/ncb3107

Review

Tipping the metabolic scales towards increased longevity in mammals

Celine E Riera et al. Nat Cell Biol. 2015 Mar.

Abstract

A hallmark of ageing is dysfunction in nutrient signalling pathways that regulate glucose homeostasis, negatively affecting whole-body energy metabolism and ultimately increasing the organism's susceptibility to disease. Maintenance of insulin sensitivity depends on functional mitochondrial networks, but is compromised by alterations in mitochondrial energy metabolism during ageing. Here we discuss metabolic paradigms that influence mammalian longevity, and highlight recent advances in identifying fundamental signalling pathways that influence metabolic health and ageing through mitochondrial perturbations.

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