Prednisolone or pentoxifylline for alcoholic hepatitis - PubMed (original) (raw)
Randomized Controlled Trial
. 2015 Apr 23;372(17):1619-28.
doi: 10.1056/NEJMoa1412278.
Paul Richardson, Michael Allison, Andrew Austin, Megan Bowers, Christopher P Day, Nichola Downs, Dermot Gleeson, Alastair MacGilchrist, Allister Grant, Steven Hood, Steven Masson, Anne McCune, Jane Mellor, John O'Grady, David Patch, Ian Ratcliffe, Paul Roderick, Louise Stanton, Nikhil Vergis, Mark Wright, Stephen Ryder, Ewan H Forrest; STOPAH Trial
Collaborators, Affiliations
- PMID: 25901427
- DOI: 10.1056/NEJMoa1412278
Free article
Randomized Controlled Trial
Prednisolone or pentoxifylline for alcoholic hepatitis
Mark R Thursz et al. N Engl J Med. 2015.
Free article
Abstract
Background: Alcoholic hepatitis is a clinical syndrome characterized by jaundice and liver impairment that occurs in patients with a history of heavy and prolonged alcohol use. The short-term mortality among patients with severe disease exceeds 30%. Prednisolone and pentoxifylline are both recommended for the treatment of severe alcoholic hepatitis, but uncertainty about their benefit persists.
Methods: We conducted a multicenter, double-blind, randomized trial with a 2-by-2 factorial design to evaluate the effect of treatment with prednisolone or pentoxifylline. The primary end point was mortality at 28 days. Secondary end points included death or liver transplantation at 90 days and at 1 year. Patients with a clinical diagnosis of alcoholic hepatitis and severe disease were randomly assigned to one of four groups: a group that received a pentoxifylline-matched placebo and a prednisolone-matched placebo, a group that received prednisolone and a pentoxifylline-matched placebo, a group that received pentoxifylline and a prednisolone-matched placebo, or a group that received both prednisolone and pentoxifylline.
Results: A total of 1103 patients underwent randomization, and data from 1053 were available for the primary end-point analysis. Mortality at 28 days was 17% (45 of 269 patients) in the placebo-placebo group, 14% (38 of 266 patients) in the prednisolone-placebo group, 19% (50 of 258 patients) in the pentoxifylline-placebo group, and 13% (35 of 260 patients) in the prednisolone-pentoxifylline group. The odds ratio for 28-day mortality with pentoxifylline was 1.07 (95% confidence interval [CI], 0.77 to 1.49; P=0.69), and that with prednisolone was 0.72 (95% CI, 0.52 to 1.01; P=0.06). At 90 days and at 1 year, there were no significant between-group differences. Serious infections occurred in 13% of the patients treated with prednisolone versus 7% of those who did not receive prednisolone (P=0.002).
Conclusions: Pentoxifylline did not improve survival in patients with alcoholic hepatitis. Prednisolone was associated with a reduction in 28-day mortality that did not reach significance and with no improvement in outcomes at 90 days or 1 year. (Funded by the National Institute for Health Research Health Technology Assessment program; STOPAH EudraCT number, 2009-013897-42 , and Current Controlled Trials number, ISRCTN88782125 ).
Comment in
- Prednisolone or Pentoxifylline for Alcoholic Hepatitis.
Thursz MR, Forrest EH, Ryder S; STOPAH investigators. Thursz MR, et al. N Engl J Med. 2015 Jul 16;373(3):282-3. doi: 10.1056/NEJMc1506342. N Engl J Med. 2015. PMID: 26176387 No abstract available. - Prednisolone or Pentoxifylline for Alcoholic Hepatitis.
Verbeke L, Laleman W, Nevens F. Verbeke L, et al. N Engl J Med. 2015 Jul 16;373(3):281. doi: 10.1056/NEJMc1506342. N Engl J Med. 2015. PMID: 26176388 No abstract available. - Prednisolone or Pentoxifylline for Alcoholic Hepatitis.
DiNubile MJ. DiNubile MJ. N Engl J Med. 2015 Jul 16;373(3):281-2. doi: 10.1056/NEJMc1506342. N Engl J Med. 2015. PMID: 26176389 No abstract available.
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