MicroRNA-205 inhibits cancer cell migration and invasion via modulation of centromere protein F regulating pathways in prostate cancer - PubMed (original) (raw)
doi: 10.1111/iju.12829. Epub 2015 Jun 7.
Affiliations
- PMID: 26059417
- DOI: 10.1111/iju.12829
MicroRNA-205 inhibits cancer cell migration and invasion via modulation of centromere protein F regulating pathways in prostate cancer
Rika Nishikawa et al. Int J Urol. 2015 Sep.
Abstract
Objectives: To investigate the functional roles of microRNA-205 in the modulation of novel cancer pathways in prostate cancer cells.
Methods: Functional studies of microRNA-205 were carried out to investigate cell proliferation, migration and invasion in prostate cancer cell lines (PC3 and DU145) by restoration of mature microRNA. In silico database and genome-wide gene expression analyses were carried out to identify molecular targets and pathways mediated by microRNA-205. Loss-of-function studies were applied to microRNA-205 target genes.
Results: Restoration of microRNA-205 in cancer cell lines significantly inhibited cancer cell migration and invasion. Our data showed that the centromere protein F gene was overexpressed in prostate cancer clinical specimens and was a direct target of microRNA-205 regulation. Silencing of centromere protein F significantly inhibited cancer cell migration and invasion. Furthermore, MCM7, an oncogenic gene functioning downstream of centromere protein F, was identified by si-centromere protein F transfectants in prostate cancer cells.
Conclusions: Loss of tumor-suppressive microRNA-205 seems to enhance cancer cell migration and invasion in prostate cancer through direct regulation of centromere protein F. Our data describing pathways regulated by tumor-suppressive microRNA-205 provide new insights into the potential mechanisms of prostate cancer oncogenesis and metastasis.
Keywords: centromere protein F; microRNA; microRNA-205; prostate cancer; tumor suppressor.
© 2015 The Japanese Urological Association.
Comment in
- Editorial Comment to MicroRNA-205 inhibits cancer cell migration and invasion via modulation of centromere protein F regulating pathways in prostate cancer.
Kobayashi T. Kobayashi T. Int J Urol. 2015 Sep;22(9):877. doi: 10.1111/iju.12883. Epub 2015 Jul 26. Int J Urol. 2015. PMID: 26211479 No abstract available.
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