The Association between Glyceraldehyde-Derived Advanced Glycation End-Products and Colorectal Cancer Risk - PubMed (original) (raw)

. 2015 Dec;24(12):1855-63.

doi: 10.1158/1055-9965.EPI-15-0422. Epub 2015 Sep 24.

Masayoshi Takeuchi 2, Hideyuki Hyogo 3, Gail McKeown-Eyssen 4, Sho-Ichi Yamagishi 5, Kazuaki Chayama 3, Peter J O'Brien 6, Pietro Ferrari 1, Kim Overvad 7, Anja Olsen 8, Anne Tjønneland 8, Marie-Christine Boutron-Ruault 9, Nadia Bastide 9, Franck Carbonnel 10, Tilman Kühn 11, Rudolf Kaaks 11, Heiner Boeing 12, Krasimira Aleksandrova 12, Antonia Trichopoulou 13, Pagona Lagiou 14, Effie Vasilopoulou 15, Giovanna Masala 16, Valeria Pala 17, Maria Santucci De Magistris 18, Rosario Tumino [ 19](#full-view-affiliation-19 "Cancer Registry and Histopathology Unit, "Civic - MP Arezzo" Hospital, Ragusa, Italy."), Alessio Naccarati 20, H B Bueno-de-Mesquita 21, Petra H Peeters 22, Elisabete Weiderpass 23, J Ramón Quirós 24, Paula Jakszyn 25, María-José Sánchez 26, Miren Dorronsoro 27, Diana Gavrila 28, Eva Ardanaz 29, Martin Rutegård 30, Hanna Nyström 30, Nicholas J Wareham 31, Kay-Tee Khaw 32, Kathryn E Bradbury 33, Isabelle Romieu 1, Heinz Freisling 1, Faidra Stavropoulou 1, Marc J Gunter 34, Amanda J Cross 34, Elio Riboli 34, Mazda Jenab 35, W Robert Bruce 36

Affiliations

The Association between Glyceraldehyde-Derived Advanced Glycation End-Products and Colorectal Cancer Risk

So Yeon Kong et al. Cancer Epidemiol Biomarkers Prev. 2015 Dec.

Abstract

Background: A large proportion of colorectal cancers are thought to be associated with unhealthy dietary and lifestyle exposures, particularly energy excess, obesity, hyperinsulinemia, and hyperglycemia. It has been suggested that these processes stimulate the production of toxic reactive carbonyls from sugars such as glyceraldehyde. Glyceraldehyde contributes to the production of a group of compounds known as glyceraldehyde-derived advanced glycation end-products (glycer-AGEs), which may promote colorectal cancer through their proinflammatory and pro-oxidative properties. The objective of this study nested within a prospective cohort was to explore the association of circulating glycer-AGEs with risk of colorectal cancer.

Methods: A total of 1,055 colorectal cancer cases (colon n = 659; rectal n = 396) were matchced (1:1) to control subjects. Circulating glycer-AGEs were measured by a competitive ELISA. Multivariable conditional logistic regression models were used to calculate ORs and 95% confidence intervals (95% CI), adjusting for potential confounding factors, including smoking, alcohol, physical activity, body mass index, and diabetes status.

Results: Elevated glycer-AGEs levels were not associated with colorectal cancer risk (highest vs. lowest quartile, 1.10; 95% CI, 0.82-1.49). Subgroup analyses showed possible divergence by anatomical subsites (OR for colon cancer, 0.83; 95% CI, 0.57-1.22; OR for rectal cancer, 1.90; 95% CI, 1.14-3.19; Pheterogeneity = 0.14).

Conclusions: In this prospective study, circulating glycer-AGEs were not associated with risk of colon cancer, but showed a positive association with the risk of rectal cancer.

Impact: Further research is needed to clarify the role of toxic products of carbohydrate metabolism and energy excess in colorectal cancer development.

©2015 American Association for Cancer Research.

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Conflict of interest statement

Conflict of interest:

The authors declare that they have no competing or conflict of interests.

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