Emerging aspects of nanotoxicology in health and disease: From agriculture and food sector to cancer therapeutics - PubMed (original) (raw)
Review
doi: 10.1016/j.fct.2016.03.003. Epub 2016 Mar 8.
Konstantina Karamanou 2, Ayse Basak Engin 3, Chrysostomi Gialeli 4, Anca Oana Docea 5, Demitrios H Vynios 6, Mauro S G Pavão 7, Kirill S Golokhvast 8, Mikhail I Shtilman 9, Athanassios Argiris 10, Ekaterina Shishatskaya 11, Aristidis M Tsatsakis 12
Affiliations
- PMID: 26969113
- DOI: 10.1016/j.fct.2016.03.003
Free article
Review
Emerging aspects of nanotoxicology in health and disease: From agriculture and food sector to cancer therapeutics
Zoi Piperigkou et al. Food Chem Toxicol. 2016 May.
Free article
Abstract
Nanotechnology is an evolving scientific field that has allowed the manufacturing of materials with novel physicochemical and biological properties, offering a wide spectrum of potential applications. Properties of nanoparticles that contribute to their usefulness include their markedly increased surface area in relation to mass, surface reactivity and insolubility, ability to agglomerate or change size in different media and enhanced endurance over conventional-scale substance. Here, we review nanoparticle classification and their emerging applications in several fields; from active food packaging to drug delivery and cancer research. Nanotechnology has exciting therapeutic applications, including novel drug delivery for the treatment of cancer. Additionally, we discuss that exposure to nanostructures incorporated to polymer composites, may result in potential human health risks. Therefore, the knowledge of processes, including absorption, distribution, metabolism and excretion, as well as careful toxicological assessment is critical in order to determine the effects of nanomaterials in humans and other biological systems. Expanding the knowledge of nanoparticle toxicity will facilitate designing of safer nanocomposites and their application in a beneficial manner.
Keywords: Extracellular matrix; Nanomedicine; Nanoparticles; Nanotechnology; Nanotoxicology.
Copyright © 2016 Elsevier Ltd. All rights reserved.
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