Cancer prevention and therapy through the modulation of transcription factors by bioactive natural compounds - PubMed (original) (raw)
Review
doi: 10.1016/j.semcancer.2016.03.005. Epub 2016 Mar 30.
Jong Hyun Lee 2, Edna Zhi Pei Chai 1, Madhu Mathi Kanchi 3, Shreya Kar 4, Frank Arfuso 5, Arunasalam Dharmarajan 5, Alan Prem Kumar 6, Perumal Samy Ramar 7, Chung Yeng Looi 8, Mohammad Rais Mustafa 8, Vinay Tergaonkar 9, Anupam Bishayee 10, Kwang Seok Ahn 11, Gautam Sethi 12
Affiliations
- PMID: 27038646
- DOI: 10.1016/j.semcancer.2016.03.005
Review
Cancer prevention and therapy through the modulation of transcription factors by bioactive natural compounds
Muthu K Shanmugam et al. Semin Cancer Biol. 2016 Oct.
Abstract
The association between chronic inflammation and cancer development has been well documented. One of the major obstacles in cancer treatment is the persistent autocrine and paracrine activation of pro-inflammatory transcription factors such as nuclear factor-κB, signal transducer and activator of transcription 3, activator protein 1, fork head box protein M1, and hypoxia-inducible factor 1α in a wide variety of tumor cell lines and patient specimens. This, in turn, leads to an accelerated production of cellular adhesion molecules, inflammatory cytokines, chemokines, anti-apoptotic molecules, and inducible nitric oxide synthase. Numerous medicinal plant-derived compounds have made a tremendous impact in drug discovery research endeavors, and have been reported to modulate the activation of diverse oncogenic transcription factors in various tumor models. Moreover, novel therapeutic combinations of standard chemotherapeutic drugs with these agents have significantly improved patient survival by making cancer cells more susceptible to chemotherapy and radiotherapy. In this review, we critically analyze the existing literature on the modulation of diverse transcription factors by various natural compounds and provide views on new directions for accelerating the discovery of novel drug candidates derived from Mother Nature.
Keywords: Cancer; Chemoprevention; Natural products; Therapy; Transcription factors.
Copyright © 2016 Elsevier Ltd. All rights reserved.
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