Effects of melatonin on cardiovascular diseases: progress in the past year - PubMed (original) (raw)

Review

Effects of melatonin on cardiovascular diseases: progress in the past year

Hang Sun et al. Curr Opin Lipidol. 2016 Aug.

Abstract

Purpose of review: Melatonin is a neuroendocrine hormone synthesized primarily by the pineal gland. Numerous studies have suggested that melatonin plays an important role in various cardiovascular diseases. In this article, recent progress regarding melatonin's effects on cardiovascular diseases is reviewed.

Recent findings: In the past year, studies have focused on the mechanism of protection of melatonin on cardiovascular diseases, including myocardial ischemia-reperfusion injury, myocardial hypoxia-reoxygenation injury, pulmonary hypertension, hypertension, atherosclerosis, valvular heart diseases, and other cardiovascular diseases.

Summary: Studies have demonstrated that melatonin has significant effects on ischemia-reperfusion injury, myocardial chronic intermittent hypoxia injury, pulmonary hypertension, hypertension, valvular heart diseases, vascular diseases, and lipid metabolism. As an inexpensive and well tolerated drug, melatonin may be a new therapeutic option for cardiovascular disease.

PubMed Disclaimer

Figures

Box 1

no caption available

Similar articles

• Effects of melatonin on cardiovascular risk factors and metabolic syndrome: a comprehensive review.
  Imenshahidi M, Karimi G, Hosseinzadeh H. Imenshahidi M, et al. Naunyn Schmiedebergs Arch Pharmacol. 2020 Apr;393(4):521-536. doi: 10.1007/s00210-020-01822-4. Epub 2020 Jan 30. Naunyn Schmiedebergs Arch Pharmacol. 2020. PMID: 32002576 Review.
• Beneficial effects of melatonin in cardiovascular disease.
  Reiter RJ, Tan DX, Paredes SD, Fuentes-Broto L. Reiter RJ, et al. Ann Med. 2010 May 6;42(4):276-85. doi: 10.3109/07853890903485748. Ann Med. 2010. PMID: 20455793 Review.
• Melatonin: a potential intervention for hepatic steatosis.
  Sun H, Huang FF, Qu S. Sun H, et al. Lipids Health Dis. 2015 Jul 22;14:75. doi: 10.1186/s12944-015-0081-7. Lipids Health Dis. 2015. PMID: 26199093 Free PMC article. Review.
• New Perspectives on the Role and Therapeutic Potential of Melatonin in Cardiovascular Diseases.
  Gu P, Wu Y, Lu W. Gu P, et al. Am J Cardiovasc Drugs. 2024 Mar;24(2):171-195. doi: 10.1007/s40256-024-00631-x. Epub 2024 Mar 4. Am J Cardiovasc Drugs. 2024. PMID: 38436867 Review.
• Melatonin in cardiovascular disease.
  Dominguez-Rodriguez A. Dominguez-Rodriguez A. Expert Opin Investig Drugs. 2012 Nov;21(11):1593-6. doi: 10.1517/13543784.2012.716037. Epub 2012 Aug 23. Expert Opin Investig Drugs. 2012. PMID: 22916801

Cited by

• Melatonin Plays a Critical Protective Role in Nicotine-Related Abdominal Aortic Aneurysm.
  Duan L, Li S, Wang L, Jing Y, Li G, Sun Y, Sun W, Li Y, Zhao L, Xin S. Duan L, et al. Front Physiol. 2020 Jul 17;11:866. doi: 10.3389/fphys.2020.00866. eCollection 2020. Front Physiol. 2020. PMID: 32765304 Free PMC article.
• Regulatory Effects of Statins on SIRT1 and Other Sirtuins in Cardiovascular Diseases.
  Khayatan D, Razavi SM, Arab ZN, Khanahmadi M, Momtaz S, Butler AE, Montecucco F, Markina YV, Abdolghaffari AH, Sahebkar A. Khayatan D, et al. Life (Basel). 2022 May 20;12(5):760. doi: 10.3390/life12050760. Life (Basel). 2022. PMID: 35629426 Free PMC article. Review.
• Melatonin ameliorates myocardial injury by reducing apoptosis and autophagy of cardiomyocytes in a rat cardiopulmonary bypass model.
  Huang X, Hou J, Huang S, Feng K, Yue Y, Li H, Huang S, Liang M, Chen G, Wu Z. Huang X, et al. PeerJ. 2021 Apr 15;9:e11264. doi: 10.7717/peerj.11264. eCollection 2021. PeerJ. 2021. PMID: 33954056 Free PMC article.
• The role of AQP3 and AQP4 channels in cisplatin-induced cardiovascular edema and the protective effect of melatonin.
  Koral L, Ovali MA, Tufekcioglu NK, Karakilic E, Adali Y, Uzun M. Koral L, et al. Mol Biol Rep. 2021 Nov;48(11):7457-7465. doi: 10.1007/s11033-021-06763-6. Epub 2021 Oct 16. Mol Biol Rep. 2021. PMID: 34657253
• Application of Monte Carlo cross-validation to identify pathway cross-talk in neonatal sepsis.
  Zhang Y, Liu C, Wang J, Li X. Zhang Y, et al. Exp Biol Med (Maywood). 2018 Mar;243(5):444-450. doi: 10.1177/1535370218759635. Exp Biol Med (Maywood). 2018. PMID: 29513099 Free PMC article.

References

1. 1. Hardeland R, Pandi-Perumal SR, Cardinali DP. Melatonin. Int J Biochem Cell Biol 2006; 38:313–316. - PubMed
2. 1. Skene DJ, Arendt J. Human circadian rhythms: physiological and therapeutic relevance of light and melatonin. Ann Clin Biochem 2006; 43:344–353. - PubMed
3. 1. Arendt J, Bojkowski C, Folkard S, et al. Some effects of melatonin and the control of its secretion in humans. Ciba Found Symp 1985; 117:266–283. - PubMed
4. 1. Sun H, Huang FF, Qu S. Melatonin: a potential intervention for hepatic steatosis. Lipids Health Dis 2015; 14:75. - PMC - PubMed
5. 1. Agil A, Navarro-Alarcon M, Ruiz R, et al. Beneficial effects of melatonin on obesity and lipid profile in young Zucker diabetic fatty rats. J Pineal Res 2011; 50:207–212. - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Europe PubMed Central
  • Ingenta plc
  • Ovid Technologies, Inc.
  • PubMed Central
  • Wolters Kluwer

• Other Literature Sources

  • The Lens - Patent Citations Database
  • scite Smart Citations

• Research Materials

  • NCI CPTC Antibody Characterization Program

• Miscellaneous

  • NCI CPTAC Assay Portal