Inhibitory activity on type 2 diabetes and hypertension key-enzymes, and antioxidant capacity of Veronica persica phenolic-rich extracts - PubMed (original) (raw)
. 2016 May 30;62(6):80-5.
Affiliations
- PMID: 27262808
Free article
Inhibitory activity on type 2 diabetes and hypertension key-enzymes, and antioxidant capacity of Veronica persica phenolic-rich extracts
M Sharifi-Rad et al. Cell Mol Biol (Noisy-le-grand). 2016.
Free article
Abstract
Veronica genus (Plantaginaceae) is broadly distributed in different habitats. In this study, the inhibitory activity of free soluble and conjugated phenolic extracts of Veronica persica on key enzymes associated to type 2 diabetes (α-glucosidase and α-amylase) and hypertension (angiotensin I converting enzyme, ACE) was assessed, as well as their antioxidant power. Our results showed that both the extracts inhibited α-amylase, α-glucosidase and ACE in a dose-dependent manner. In particular, free phenolic extract significantly (P<0.05) inhibited α-glucosidase (IC50 532.97 µg/mL), whereas conjugated phenolic extract significantly (P<0.05) inhibited α-amylase (IC50 489.73 µg/mL) and ACE (290.06 µg/mL). The enzyme inhibitory activities of the extracts were not associated with their phenolic content. Anyway, the inhibition of α-amylase, α-glucosidase and ACE, along with the antioxidant capacity of the phenolic-rich extracts, could represent a putative mechanism through which V. persica exerts its antidiabetes and antihypertension effects.
Similar articles
- Soybean phenolic-rich extracts inhibit key-enzymes linked to type 2 diabetes (α-amylase and α-glucosidase) and hypertension (angiotensin I converting enzyme) in vitro.
Ademiluyi AO, Oboh G. Ademiluyi AO, et al. Exp Toxicol Pathol. 2013 Mar;65(3):305-9. doi: 10.1016/j.etp.2011.09.005. Epub 2011 Oct 17. Exp Toxicol Pathol. 2013. PMID: 22005499 - Evaluation of Rhodiola crenulata and Rhodiola rosea for management of type II diabetes and hypertension.
Kwon YI, Jang HD, Shetty K. Kwon YI, et al. Asia Pac J Clin Nutr. 2006;15(3):425-32. Asia Pac J Clin Nutr. 2006. PMID: 16837437 - Phenolic-rich extracts from selected tropical underutilized legumes inhibit α-amylase, α-glucosidase, and angiotensin I converting enzyme in vitro.
Ademiluyi AO, Oboh G. Ademiluyi AO, et al. J Basic Clin Physiol Pharmacol. 2012 Jan 19;23(1):17-25. doi: 10.1515/jbcpp-2011-0005. J Basic Clin Physiol Pharmacol. 2012. PMID: 22865445 - α-Glucosidase and α-amylase inhibitors from seed oil: A review of liposoluble substance to treat diabetes.
Teng H, Chen L. Teng H, et al. Crit Rev Food Sci Nutr. 2017 Nov 2;57(16):3438-3448. doi: 10.1080/10408398.2015.1129309. Crit Rev Food Sci Nutr. 2017. PMID: 26854322 Review. - Screening of antidiabetic and antioxidant activities of medicinal plants.
Shori AB. Shori AB. J Integr Med. 2015 Sep;13(5):297-305. doi: 10.1016/S2095-4964(15)60193-5. J Integr Med. 2015. PMID: 26343100 Review.
Cited by
- Hydrodistillation and Microwave Extraction of Volatile Compounds: Comparing Data for Twenty-One Veronica Species from Different Habitats.
Dunkić V, Nazlić M, Ruščić M, Vuko E, Akrap K, Topić S, Milović M, Vuletić N, Puizina J, Jurišić Grubešić R, Srečec S, Kremer D. Dunkić V, et al. Plants (Basel). 2022 Mar 28;11(7):902. doi: 10.3390/plants11070902. Plants (Basel). 2022. PMID: 35406882 Free PMC article. - Free Volatile Compounds of Veronica austriaca ssp. jacquinii (Baumg.) Eb. Fisch. and Their Biological Activity.
Nazlić M, Fredotović Ž, Vuko E, Vuletić N, Ljubenkov I, Kremer D, Jurišić Grubešić R, Stabentheiner E, Randić M, Dunkić V. Nazlić M, et al. Plants (Basel). 2021 Nov 20;10(11):2529. doi: 10.3390/plants10112529. Plants (Basel). 2021. PMID: 34834892 Free PMC article. - Endemic Veronica saturejoides Vis. ssp. _saturejoides_-Chemical Composition and Antioxidant Activity of Free Volatile Compounds.
Nazlić M, Kremer D, Grubešić RJ, Soldo B, Vuko E, Stabentheiner E, Ballian D, Bogunić F, Dunkić V. Nazlić M, et al. Plants (Basel). 2020 Nov 25;9(12):1646. doi: 10.3390/plants9121646. Plants (Basel). 2020. PMID: 33255775 Free PMC article. - Structure-Activity-Relationship and Mechanistic Insights for Anti-HIV Natural Products.
Kaur R, Sharma P, Gupta GK, Ntie-Kang F, Kumar D. Kaur R, et al. Molecules. 2020 Apr 29;25(9):2070. doi: 10.3390/molecules25092070. Molecules. 2020. PMID: 32365518 Free PMC article. Review. - Veronica Plants-Drifting from Farm to Traditional Healing, Food Application, and Phytopharmacology.
Salehi B, Shivaprasad Shetty M, V Anil Kumar N, Živković J, Calina D, Oana Docea A, Emamzadeh-Yazdi S, Sibel Kılıç C, Goloshvili T, Nicola S, Pignata G, Sharopov F, Del Mar Contreras M, Cho WC, Martins N, Sharifi-Rad J. Salehi B, et al. Molecules. 2019 Jul 4;24(13):2454. doi: 10.3390/molecules24132454. Molecules. 2019. PMID: 31277407 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous