Melatonin has multiorgan effects - PubMed (original) (raw)
Review
doi: 10.1093/ehjcvp/pvv037. Epub 2016 Aug 8.
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- PMID: 27533945
- DOI: 10.1093/ehjcvp/pvv037
Review
Melatonin has multiorgan effects
Lionel H Opie et al. Eur Heart J Cardiovasc Pharmacother. 2016 Oct.
Abstract
Melatonin, widely used to counter transatlantic travel jet lag and insomnia, is synthesized in the suprachiasmatic nucleus of the anterior pituitary gland. Its release into the circulation is stimulated by the onset of darkness, followed by a progressive decrease in blood levels with the onset of dawn. Melatonin administration can maintain the quality of sleep and help to counteract age-induced cognitive decline. Melatonin can also limit the severity of a variety of cardiovascular and cerebrovascular diseases, diabetes, and cancer.
Keywords: Anticancer; Cardioprotection; Day–night cycle; Melatonin; Multiorgan; Sleep.
Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2015. For permissions please email: journals.permissions@oup.com.
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