Flavonoids are scavengers of superoxide anions - PubMed (original) (raw)
Flavonoids are scavengers of superoxide anions
J Robak et al. Biochem Pharmacol. 1988.
Abstract
Seven flavonoids and three non-flavonoid antioxidants, i.e. butylated hydroxyanisole, chlorpromazine and BW 755 C, were studied as potential scavengers of oxygen free radicals. Superoxide anions were generated enzymatically in a xanthine-xanthine oxidase system and non-enzymatically in a phenazine methosulphate-NADH system, and assayed by reduction of nitro blue tetrazolium. The generation of malonaldehyde (MDA) by the ascorbate-stimulated air-oxidised boiled rat liver microsomes was considered as an index of the non-enzymatic formation of hydroxyl radicals. Flavonoids but not non-flavonoid antioxidants lowered the concentration of detectable superoxide anions in both enzymic and non-enzymic systems which generated these SOD-sensitive radicals. The most effective inhibitors of superoxide anions were quercetin, myricetin and rutin. Four out of seven investigated flavonoids seemed also to suppress the activity of xanthine oxidase as measured by a decrease in uric acid biosynthesis. All ten investigated compounds inhibited the MDA formation by rat liver microsomes. Non-flavonoid antioxidants were more potent MDA inhibitors than flavonoids. It is concluded that antioxidant properties of flavonoids are effected mainly via scavenging of superoxide anions whereas non-flavonoid antioxidants act on further links of free radical chain reactions, most likely by scavenging of hydroxyl radicals.
Similar articles
- Picroliv, picroside-I and kutkoside from Picrorhiza kurrooa are scavengers of superoxide anions.
Chander R, Kapoor NK, Dhawan BN. Chander R, et al. Biochem Pharmacol. 1992 Jul 7;44(1):180-3. doi: 10.1016/0006-2952(92)90054-m. Biochem Pharmacol. 1992. PMID: 1321626 - High density lipoprotein is a scavenger of superoxide anions.
Chander R, Kapoor NK. Chander R, et al. Biochem Pharmacol. 1990 Oct 1;40(7):1663-5. doi: 10.1016/0006-2952(90)90469-2. Biochem Pharmacol. 1990. PMID: 2171536 - Flavonoids as superoxide scavengers and antioxidants.
Chen YT, Zheng RL, Jia ZJ, Ju Y. Chen YT, et al. Free Radic Biol Med. 1990;9(1):19-21. doi: 10.1016/0891-5849(90)90045-k. Free Radic Biol Med. 1990. PMID: 2170243 - Free radical scavengers in myocardial ischemia.
Simpson PJ, Mickelson JK, Lucchesi BR. Simpson PJ, et al. Fed Proc. 1987 May 15;46(7):2413-21. Fed Proc. 1987. PMID: 2436951 Review. - Review of the antioxidant potential of flavonoids as a subgroup of polyphenols and partial substitute for synthetic antioxidants.
Hassanpour SH, Doroudi A. Hassanpour SH, et al. Avicenna J Phytomed. 2023 Jul-Aug;13(4):354-376. doi: 10.22038/AJP.2023.21774. Avicenna J Phytomed. 2023. PMID: 37663389 Free PMC article. Review.
Cited by
- Rutoside and Ascorbic Acid in the Treatment of Schamberg Pigmented Purpuric Dermatosis.
Morquette AJ, Lee JB, Grossman SK, Hsu S. Morquette AJ, et al. Cureus. 2021 Apr 20;13(4):e14592. doi: 10.7759/cureus.14592. Cureus. 2021. PMID: 34036010 Free PMC article. - Phloridzin Acts as an Inhibitor of Protein-Tyrosine Phosphatase MEG2 Relevant to Insulin Resistance.
Yoon SY, Yu JS, Hwang JY, So HM, Seo SO, Kim JK, Jang TS, Chung SJ, Kim KH. Yoon SY, et al. Molecules. 2021 Mar 14;26(6):1612. doi: 10.3390/molecules26061612. Molecules. 2021. PMID: 33799458 Free PMC article. - Screening of Antioxidative Properties and Inhibition of Inflammation-Linked Enzymes by Aqueous and Ethanolic Extracts of Plants Traditionally Used in Wound Healing in Poland.
Mainka M, Czerwińska ME, Osińska E, Ziaja M, Bazylko A. Mainka M, et al. Antioxidants (Basel). 2021 Apr 28;10(5):698. doi: 10.3390/antiox10050698. Antioxidants (Basel). 2021. PMID: 33925100 Free PMC article. - Assessment of effect of hydroalcoholic and decoction methods on extraction of antioxidants from selected Indian medicinal plants.
Kaneria M, Kanani B, Chanda S. Kaneria M, et al. Asian Pac J Trop Biomed. 2012 Mar;2(3):195-202. doi: 10.1016/S2221-1691(12)60041-0. Asian Pac J Trop Biomed. 2012. PMID: 23569897 Free PMC article. - In vitro antioxidant activity of extracts from the leaves of Abies pindrow Royle.
Gupta D, Bhardwaj R, Gupta RK. Gupta D, et al. Afr J Tradit Complement Altern Med. 2011;8(4):391-7. doi: 10.4314/ajtcam.v8i4.8. Epub 2011 Jun 1. Afr J Tradit Complement Altern Med. 2011. PMID: 22654216 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources