Biology of premature ageing in survivors of cancer - PubMed (original) (raw)

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Biology of premature ageing in survivors of cancer

Margaret C Cupit-Link et al. ESMO Open. 2017.

Abstract

Over 30 million cancer survivors exist worldwide. Survivors have an earlier onset and higher incidence of chronic comorbidities, including endocrinopathies, cardiac dysfunction, osteoporosis, pulmonary fibrosis, secondary cancers and frailty than the general population; however, the fundamental basis of these changes at the cellular level is unknown. An electronic search was performed on Embase, Medline In-Process & Other Non-Indexed Citations, and the Cochrane Central Register of Controlled Trials. Original articles addressing the cellular biology of ageing and/or the mechanisms of cancer therapies similar to ageing mechanisms were included, and references of these articles were reviewed for further search. We found multiple biological process of ageing at the cellular level and their association with cancer therapies, as well as with clinical effects. The direct effects of various chemotherapies and radiation on telomere length, senescent cells, epigenetic modifications and microRNA were found. We review the effects of cancer therapies on recognised hallmarks of ageing. Long-term comorbidities seen in cancer survivors mimic the phenotypes of ageing and likely result from the interaction between therapeutic exposures and the underlying biology of ageing. Long-term follow-up of cancer survivors and research on prevention strategies should be pursued to increase the length and quality of life among the growing population of cancer survivors.

Keywords: aging; anticancer therapeutics; long term side effects.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1

Figure 1

Diagram depicting age-related effects of respective cancer therapies. CHF, congestive heart failure; RT, radiation therapy.

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References

    1. Ferlay J, Soerjomataram I, Dikshit R, et al. . Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 2015;136:E359–E386. 10.1002/ijc.29210 - DOI - PubMed
    1. Oeffinger KC, Mertens AC, Sklar CA, et al. . Childhood Cancer Survivor Study. Chronic health conditions in adult survivors of childhood cancer. N Engl J Med 2006;355:1572–82. 10.1056/NEJMsa060185 - DOI - PubMed
    1. Armstrong GT, Liu Q, Yasui Y, et al. . Late mortality among 5-year survivors of childhood cancer: a summary from the Childhood Cancer Survivor Study. J Clin Oncol 2009;27:2328–38. 10.1200/JCO.2008.21.1425 - DOI - PMC - PubMed
    1. Arora M, Sun CL, Ness KK, et al. . Physiologic frailty in nonelderly hematopoietic cell transplantation patients: results from the bone marrow transplant survivor study. JAMA Oncol 2016;2:1277-1286 10.1001/jamaoncol.2016.0855 - DOI - PMC - PubMed
    1. Armstrong GT, Chen Y, Yasui Y, et al. . Reduction in late mortality among 5-year survivors of childhood cancer. N Engl J Med 2016;374:833–42. 10.1056/NEJMoa1510795 - DOI - PMC - PubMed

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