Antimicrobial Resistance in Campylobacter spp - PubMed (original) (raw)

Review

Antimicrobial Resistance in Campylobacter spp

Zhangqi Shen et al. Microbiol Spectr. 2018 Apr.

Abstract

Campylobacter is a major foodborne pathogen and has become increasingly resistant to clinically important antimicrobials. To cope with the selection pressure from antimicrobial use in both veterinary and human medicine, Campylobacter has developed multiple mechanisms for antibiotic resistance, including modification or mutation of antimicrobial targets, modification or inactivation of antibiotics, and reduced drug accumulation by drug efflux pumps. Some of these mechanisms confer resistance to a specific class of antimicrobials, while others give rise to multidrug resistance. Notably, new antibiotic resistance mechanisms continuously emerge in Campylobacter, and some examples include the recently discovered multidrug resistance genomic islands harboring multiple genes involved in the resistance to aminoglycosides and macrolides, a novel Cfr(C) conferring resistance to phenicols and other drugs, and a potent multidrug efflux pump CmeABC variant (RE-CmeABC) that shows a significantly enhanced function in multidrug resistance and is associated with exceedingly high-level resistance to fluoroquinolones. These newly emerged resistance mechanisms are horizontally transferable and greatly facilitate the adaptation of Campylobacter in the food-producing environments where antibiotics are frequently used. In this article, we will discuss how Campylobacter resists the action of various classes of antimicrobials, with an emphasis on newly discovered mechanisms.

PubMed Disclaimer

Figures

FIGURE 1

FIGURE 1

Chromosomal organization and comparison of seven types (I to VII) of MDRGIs containing the erm(B) gene (modified from references –45). erm(B) is in red, aminoglycoside resistance genes are in yellow, the streptothricin resistance gene (sat4) is in blue, the tetracycline resistance gene [tet(O)] is in purple, genes with predicted functions are in green, and genes coding hypothetical proteins are in white. The tet(O) gene is intact in types V and VI but is truncated in other types. The border genes of the MDRGIs are depicted by black box arrows. The gray shading indicates regions sharing more than 98% DNA identity. A representative strain for each type of MDRGI is indicated on the right side of the panel.

Similar articles

Cited by

References

    1. WHO. 2013. The global view of campylobacteriosis. Report of an expert consultation. World Health Organization, Utrecht, The Netherlands, 9–11 July 2012. [PubMed]
    1. Allos BM. 2001. Campylobacter jejuni infections: update on emerging issues and trends. Clin Infect Dis 32:1201–1206 10.1086/319760. - DOI - PubMed
    1. Engberg J, Aarestrup FM, Taylor DE, Gerner-Smidt P, Nachamkin I. 2001. Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates. Emerg Infect Dis 7:24–34 10.3201/eid0701.010104. [PubMed] - DOI - PMC - PubMed
    1. Payot S, Bolla JM, Corcoran D, Fanning S, Mégraud F, Zhang Q. 2006. Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp. Microbes Infect 8:1967–1971 10.1016/j.micinf.2005.12.032. [PubMed] - DOI - PubMed
    1. Luangtongkum T, Jeon B, Han J, Plummer P, Logue CM, Zhang Q. 2009. Antibiotic resistance in Campylobacter: emergence, transmission and persistence. Future Microbiol 4:189–200 10.2217/17460913.4.2.189. [PubMed] - DOI - PMC - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources