Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features - PubMed (original) (raw)
Clinical Trial
. 2018 Sep 6;174(6):1388-1405.e21.
doi: 10.1016/j.cell.2018.08.041.
Gili Zilberman-Schapira 2, Jotham Suez 2, Uria Mor 2, Mally Dori-Bachash 2, Stavros Bashiardes 2, Eran Kotler 3, Maya Zur 2, Dana Regev-Lehavi 2, Rotem Ben-Zeev Brik 2, Sara Federici 2, Yotam Cohen 2, Raquel Linevsky 2, Daphna Rothschild 3, Andreas E Moor 4, Shani Ben-Moshe 4, Alon Harmelin 5, Shalev Itzkovitz 4, Nitsan Maharshak 6, Oren Shibolet 6, Hagit Shapiro 2, Meirav Pevsner-Fischer 2, Itai Sharon 7, Zamir Halpern 8, Eran Segal 9, Eran Elinav 10
Affiliations
- PMID: 30193112
- DOI: 10.1016/j.cell.2018.08.041
Free article
Clinical Trial
Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features
Niv Zmora et al. Cell. 2018.
Free article
Abstract
Empiric probiotics are commonly consumed by healthy individuals as means of life quality improvement and disease prevention. However, evidence of probiotic gut mucosal colonization efficacy remains sparse and controversial. We metagenomically characterized the murine and human mucosal-associated gastrointestinal microbiome and found it to only partially correlate with stool microbiome. A sequential invasive multi-omics measurement at baseline and during consumption of an 11-strain probiotic combination or placebo demonstrated that probiotics remain viable upon gastrointestinal passage. In colonized, but not germ-free mice, probiotics encountered a marked mucosal colonization resistance. In contrast, humans featured person-, region- and strain-specific mucosal colonization patterns, hallmarked by predictive baseline host and microbiome features, but indistinguishable by probiotics presence in stool. Consequently, probiotics induced a transient, individualized impact on mucosal community structure and gut transcriptome. Collectively, empiric probiotics supplementation may be limited in universally and persistently impacting the gut mucosa, meriting development of new personalized probiotic approaches.
Copyright © 2018 Elsevier Inc. All rights reserved.
Comment in
- Risk assessment of probiotics use requires clinical parameters.
Langella P, Chatel JM. Langella P, et al. Nat Rev Gastroenterol Hepatol. 2019 Apr;16(4):202-204. doi: 10.1038/s41575-019-0111-4. Nat Rev Gastroenterol Hepatol. 2019. PMID: 30692658 No abstract available.
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