Deregulation of SATB2 in carcinogenesis with emphasis on miRNA-mediated control - PubMed (original) (raw)

Review

Deregulation of SATB2 in carcinogenesis with emphasis on miRNA-mediated control

Qiao Yi Chen et al. Carcinogenesis. 2019.

Abstract

The special AT-rich DNA binding protein (SATB2) is a nuclear matrix-associated protein and an important transcription factor for biological development, gene regulation and chromatin remodeling. Aberrant regulation of SATB2 has been found to highly correlate with various types of cancers including lung, colon, prostate, breast, gastric and liver. Recent studies have revealed that a subset of small non-coding RNAs, termed microRNAs (miRNAs), are important regulators of SATB2 function. As post-transcriptional regulators, miRNAs have been found to have fundament importance maintaining normal cellular development. Evidence suggests that multiple miRNAs, including miR-31, miR-34, miR-182, miR-211, miR-599, are capable of regulating SATB2 in cancers of the lung, liver, colon and breast. This review examines the molecular functions of SATB2 and miRNAs in the text of cancer development and potential strategies for cancer therapy with a focus on systemic miRNA delivery.

© The Author(s) 2019. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

PubMed Disclaimer

Figures

Figure 1.

Figure 1.

Linearized SATB2 protein structure. The linearized protein structure demonstrates site of dimerization and binding domains.

Figure 2.

Figure 2.

SATB2-induced chromatin looping provides topological organization and enhanced gene expression. The figure shows how SATB2 binds to the MAR sequence along a gene and facilitates chromatin looping, which brings distal genomic loci into close spatial proximity.

Figure 3.

Figure 3.

Dual role of SATB2 in carcinogenesis and its molecular functions. The figure summarizes the molecular functions of SATB2 as well as its oncogenic and tumor-suppressive roles under different cancer contexts.

Figure 4.

Figure 4.

Illustration of miRNA binding site on SATB2 mRNA. The illustration depicts SATB2 mRNA and miRNA interaction. SATB2 has multiple binding sites for miRNAs, which are exclusively found in the 3′-UTR.

Figure 5.

Figure 5.

Illustration of miRNA delivery. miRNA delivery can be used to either inhibit target mRNAs or restore miRNA supply. The figure illustrates two prominent ways, viral and lipid-based nanoparticles, of systemic miRNA delivery in the human body.

Similar articles

Cited by

References

    1. Szemes M., et al. (2006) Isolation and characterization of SATB2, a novel AT-rich DNA binding protein expressed in development- and cell-specific manner in the rat brain. Neurochem. Res., 31, 237–246. - PubMed
    1. FitzPatrick D.R., et al. (2003) Identification of SATB2 as the cleft palate gene on 2q32-q33. Hum. Mol. Genet., 12, 2491–2501. - PubMed
    1. Zhao X., et al. (2014) The role of SATB2 in skeletogenesis and human disease. Cytokine Growth Factor Rev., 25, 35–44. - PubMed
    1. Bengani H., et al. ; UK10K Consortium (2017) Clinical and molecular consequences of disease-associated de novo mutations in SATB2. Genet. Med., 19, 900–908. - PMC - PubMed
    1. Britanova O., et al. (2005) Novel transcription factor Satb2 interacts with matrix attachment region DNA elements in a tissue-specific manner and demonstrates cell-type-dependent expression in the developing mouse CNS. Eur. J. Neurosci., 21, 658–668. - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources