Analysis from the EMPA-REG OUTCOME® trial indicates empagliflozin may assist in preventing the progression of chronic kidney disease in patients with type 2 diabetes irrespective of medications that alter intrarenal hemodynamics - PubMed (original) (raw)
Clinical Trial
. 2019 Aug;96(2):489-504.
doi: 10.1016/j.kint.2019.02.033. Epub 2019 Mar 21.
Affiliations
- PMID: 31142441
- DOI: 10.1016/j.kint.2019.02.033
Free article
Clinical Trial
Analysis from the EMPA-REG OUTCOME® trial indicates empagliflozin may assist in preventing the progression of chronic kidney disease in patients with type 2 diabetes irrespective of medications that alter intrarenal hemodynamics
Gert J Mayer et al. Kidney Int. 2019 Aug.
Free article
Abstract
In patients with type 2 diabetes mellitus (T2DM) and cardiovascular (CV) disease, empagliflozin (EMPA) decreased progression of chronic kidney disease (CKD), likely via a reduction in intraglomerular pressure. Due to prevalent comorbidities, such as hypertension and albuminuria, patients often receive other agents that alter intrarenal hemodynamics, including angiotensin converting enzyme inhibitors/angiotensin receptor blockers (ACEi/ARBs), calcium channel blockers (CCBs) and diuretics. Nonsteroidal anti-inflammatory drugs (NSAIDs) may also be used by some individuals. In this exploratory, non-prespecified analysis, we investigated whether the kidney benefits of EMPA are altered in individuals already using the medications in these categories. In the BI 10773 (Empagliflozin) Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients (EMPA-REG OUTCOME®) trial, 7020 patients were essentially equally randomized to EMPA 10 mg, 25 mg or placebo added to their standard care. Differences in risk of incident or worsening nephropathy for pooled EMPA vs placebo across subgroups by baseline background medications (to which patients were not randomized) were assessed using a Cox proportional hazards model. Risk reductions in incident or worsening nephropathy with EMPA were consistent across medication subgroups, with no heterogeneity of treatment effect. As a representative example, the risk for acute renal failure was overall slightly increased in patients using ACEi/ARBs in all groups (placebo, EMPA 10 mg or EMPA 25 mg) but incidence rates were numerically lower in those assigned to EMPA. Similar patterns were observed for other medications included in this analysis. Thus, EMPA may assist to prevent CKD progression in patients with T2DM with CV disease, irrespective of common background medications that alter intrarenal hemodynamics, and without increasing acute renal adverse events.
Keywords: ACEis; CKD; CV disease; diuretics; sodium-glucose cotransporter 2 inhibitors; type 2 diabetes.
Copyright © 2019 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.
Comment in
- SGLT2 inhibitors' interaction with other renoactive drugs in type 2 diabetes patients: still a lot to learn.
van Baar MJB, Scholtes RA, van Raalte DH. van Baar MJB, et al. Kidney Int. 2019 Aug;96(2):283-286. doi: 10.1016/j.kint.2019.03.032. Kidney Int. 2019. PMID: 31331468 - The authors reply.
Mayer GJ, Wanner C, Weir MR, Inzucchi SE, Koitka-Weber A, Hantel S, von Eynatten M, Zinman B, Cherney DZI. Mayer GJ, et al. Kidney Int. 2020 Jan;97(1):213-214. doi: 10.1016/j.kint.2019.09.027. Kidney Int. 2020. PMID: 31901342 No abstract available. - Is the joint use of diuretics and SGLT2 inhibitors beneficial in diabetic kidney disease?
León-Jiménez D, Moreno-Obregón F, Beltrán-Romero LM, Miramontes-González JP. León-Jiménez D, et al. Kidney Int. 2020 Jan;97(1):213. doi: 10.1016/j.kint.2019.08.039. Kidney Int. 2020. PMID: 31901343 No abstract available.
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