Specific Immunologic Countermeasure Protocol for Deep-Space Exploration Missions - PubMed (original) (raw)

doi: 10.3389/fimmu.2019.02407. eCollection 2019.

Satish Mehta 1, Alexander Choukèr [ 2](#full-view-affiliation-2 "Laboratory of Translational Research "Stress & Immunity", Department of Anesthesiology, Hospital of the Ludwig-Maximilians-University, Munich, Germany."), Richard J Simpson 3 4 5, Gailen Marshall 6, Jordan S Orange 7, Serena Aunon-Chancellor 8, Scott M Smith 8, Sara R Zwart 9, Raymond P Stowe 10, Martina Heer 11, Sergey Ponomarev 12, Alexandra Whitmire 13, Jean P Frippiat 14, Grace L Douglas 8, Stephanie S Krieger 13, Hernan Lorenzi 15, Judith-Irina Buchheim [ 2](#full-view-affiliation-2 "Laboratory of Translational Research "Stress & Immunity", Department of Anesthesiology, Hospital of the Ludwig-Maximilians-University, Munich, Germany."), Geoffrey S Ginsburg 16, C Mark Ott 8, Meghan Downs 13, Duane Pierson 8, Natalie Baecker 11, Clarence Sams 8, Brian Crucian 8

Affiliations

• PMID: 31681296
• PMCID: PMC6797618
• DOI: 10.3389/fimmu.2019.02407

Specific Immunologic Countermeasure Protocol for Deep-Space Exploration Missions

George Makedonas et al. Front Immunol. 2019.

No abstract available

Keywords: Herpesvirus reactivation; immune countermeasures; immune surveillance; space immunology; stress management.

PubMed Disclaimer

Similar articles

• Immune system changes during simulated planetary exploration on Devon Island, high arctic.
  Crucian B, Lee P, Stowe R, Jones J, Effenhauser R, Widen R, Sams C. Crucian B, et al. BMC Immunol. 2007 May 23;8:7. doi: 10.1186/1471-2172-8-7. BMC Immunol. 2007. PMID: 17521440 Free PMC article.
• Microgravity and immune responsiveness: implications for space travel.
  Borchers AT, Keen CL, Gershwin ME. Borchers AT, et al. Nutrition. 2002 Oct;18(10):889-98. doi: 10.1016/s0899-9007(02)00913-9. Nutrition. 2002. PMID: 12361784 Review.
• [The diagnosis of disorders of the T-cell immunity component in space flight].
  Lesniak AT, Antropova EN, Meshkov DO, Rykova MP. Lesniak AT, et al. Aviakosm Ekolog Med. 1999;33(3):62-7. Aviakosm Ekolog Med. 1999. PMID: 10485037 Russian.
• Space flight and humoral and cellular immunity of animals.
  Sonnenfeld G, Miller ES. Sonnenfeld G, et al. Physiologist. 1993;36(1 Suppl):S68-70. Physiologist. 1993. PMID: 11537429 Review.
• Monitoring immune system function and reactivation of latent viruses in the Artificial Gravity Pilot Study.
  Mehta SK, Crucian B, Pierson DL, Sams C, Stowe RP. Mehta SK, et al. J Gravit Physiol. 2007 Jul;14(1):P21-5. J Gravit Physiol. 2007. PMID: 18372687 Clinical Trial.

Cited by

• Simulated microgravity impairs human NK cell cytotoxic activity against space radiation-relevant leukemic cells.
  Kuhlman BM, Diaz JH, Simon T, Reeves KD, Walker SJ, Atala A, Almeida-Porada G, Porada CD. Kuhlman BM, et al. NPJ Microgravity. 2024 Aug 14;10(1):85. doi: 10.1038/s41526-024-00424-1. NPJ Microgravity. 2024. PMID: 39143086 Free PMC article.
• Immune system dysregulation preceding a case of laboratory-confirmed zoster/dermatitis on board the International Space Station.
  Mehta SK, Suresh R, Brandt K, Diak DM, Smith SM, Zwart SR, Douglas G, Nelman-Gonzalez M, Clemett S, Brunstetter T, Crucian BE. Mehta SK, et al. J Allergy Clin Immunol Glob. 2024 Mar 13;3(2):100244. doi: 10.1016/j.jacig.2024.100244. eCollection 2024 May. J Allergy Clin Immunol Glob. 2024. PMID: 38577482 Free PMC article.
• Editorial: Microbiota, nutrition and stress: modulators of immunity.
  Ponomarev S, Mack I, Choukér A. Ponomarev S, et al. Front Nutr. 2023 Nov 17;10:1328346. doi: 10.3389/fnut.2023.1328346. eCollection 2023. Front Nutr. 2023. PMID: 38045810 Free PMC article. No abstract available.
• Exposure of volunteers to microgravity by dry immersion bed over 21 days results in gene expression changes and adaptation of T cells.
  Gallardo-Dodd CJ, Oertlin C, Record J, Galvani RG, Sommerauer C, Kuznetsov NV, Doukoumopoulos E, Ali L, Oliveira MMS, Seitz C, Percipalle M, Nikić T, Sadova AA, Shulgina SM, Shmarov VA, Kutko OV, Vlasova DD, Orlova KD, Rykova MP, Andersson J, Percipalle P, Kutter C, Ponomarev SA, Westerberg LS. Gallardo-Dodd CJ, et al. Sci Adv. 2023 Aug 25;9(34):eadg1610. doi: 10.1126/sciadv.adg1610. Epub 2023 Aug 25. Sci Adv. 2023. PMID: 37624890 Free PMC article.
• Next generation of astronauts or ESA astronaut 2.0 concept and spotlight on immunity.
  Jacob P, Oertlin C, Baselet B, Westerberg LS, Frippiat JP, Baatout S. Jacob P, et al. NPJ Microgravity. 2023 Jun 28;9(1):51. doi: 10.1038/s41526-023-00294-z. NPJ Microgravity. 2023. PMID: 37380641 Free PMC article. Review.

References

1. 1. Crucian B, Babiak-Vazquez A, Johnston S, Pierson DL, Ott CM, Sams C. Incidence of clinical symptoms during long-duration orbital spaceflight. Int J Gen Med. (2016) 9:383–91. 10.2147/IJGM.S114188 - DOI - PMC - PubMed
2. 1. Crucian B, Johnston S, Mehta S, Stowe R, Uchakin P, Quiriarte H, et al. . A case of persistent skin rash and rhinitis with immune system dysregulation onboard the International Space Station. J Allergy Clin Immunol Pract. (2016) 4:759–62.e8. 10.1016/j.jaip.2015.12.021 - DOI - PubMed
3. 1. Makedonas G, Chouker A, Mehta S, Simpson RJ, Stowe R, Sams C, et al. Mechanistic clues to overcome spaceflight-induced immune dysregulation. Curr Pathobiol Rep. (2018) 6:185 10.1007/s40139-018-0178-6 - DOI
4. 1. Garrett-Bakelman FE, Darshi M, Green SJ, Gur RC, Lin L, Macias BR, et al. . The NASA twins study: a multidimensional analysis of a year-long human spaceflight. Science. (2019) 364:eaau8650. 10.1126/science.aau8650 - DOI - PMC - PubMed
5. 1. Rooney BV, Crucian BE, Pierson DL, Laudenslager ML, Mehta SK. Herpes virus reactivation in astronauts during spaceflight and its application on earth. Front Microbiol. (2019) 10:16. 10.3389/fmicb.2019.00016 - DOI - PMC - PubMed

Publication types

MeSH terms

LinkOut - more resources

• Full Text Sources

  • Europe PubMed Central
  • Frontiers Media SA
  • PubMed Central