Specific Immunologic Countermeasure Protocol for Deep-Space Exploration Missions - PubMed (original) (raw)

doi: 10.3389/fimmu.2019.02407. eCollection 2019.

Satish Mehta 1, Alexander Choukèr [ 2](#full-view-affiliation-2 "Laboratory of Translational Research "Stress & Immunity", Department of Anesthesiology, Hospital of the Ludwig-Maximilians-University, Munich, Germany."), Richard J Simpson 3 4 5, Gailen Marshall 6, Jordan S Orange 7, Serena Aunon-Chancellor 8, Scott M Smith 8, Sara R Zwart 9, Raymond P Stowe 10, Martina Heer 11, Sergey Ponomarev 12, Alexandra Whitmire 13, Jean P Frippiat 14, Grace L Douglas 8, Stephanie S Krieger 13, Hernan Lorenzi 15, Judith-Irina Buchheim [ 2](#full-view-affiliation-2 "Laboratory of Translational Research "Stress & Immunity", Department of Anesthesiology, Hospital of the Ludwig-Maximilians-University, Munich, Germany."), Geoffrey S Ginsburg 16, C Mark Ott 8, Meghan Downs 13, Duane Pierson 8, Natalie Baecker 11, Clarence Sams 8, Brian Crucian 8

Affiliations

• PMID: 31681296
• PMCID: PMC6797618
• DOI: 10.3389/fimmu.2019.02407

Specific Immunologic Countermeasure Protocol for Deep-Space Exploration Missions

George Makedonas et al. Front Immunol. 2019.

No abstract available

Keywords: Herpesvirus reactivation; immune countermeasures; immune surveillance; space immunology; stress management.

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References

1. 1. Crucian B, Babiak-Vazquez A, Johnston S, Pierson DL, Ott CM, Sams C. Incidence of clinical symptoms during long-duration orbital spaceflight. Int J Gen Med. (2016) 9:383–91. 10.2147/IJGM.S114188 - DOI - PMC - PubMed
2. 1. Crucian B, Johnston S, Mehta S, Stowe R, Uchakin P, Quiriarte H, et al. . A case of persistent skin rash and rhinitis with immune system dysregulation onboard the International Space Station. J Allergy Clin Immunol Pract. (2016) 4:759–62.e8. 10.1016/j.jaip.2015.12.021 - DOI - PubMed
3. 1. Makedonas G, Chouker A, Mehta S, Simpson RJ, Stowe R, Sams C, et al. Mechanistic clues to overcome spaceflight-induced immune dysregulation. Curr Pathobiol Rep. (2018) 6:185 10.1007/s40139-018-0178-6 - DOI
4. 1. Garrett-Bakelman FE, Darshi M, Green SJ, Gur RC, Lin L, Macias BR, et al. . The NASA twins study: a multidimensional analysis of a year-long human spaceflight. Science. (2019) 364:eaau8650. 10.1126/science.aau8650 - DOI - PMC - PubMed
5. 1. Rooney BV, Crucian BE, Pierson DL, Laudenslager ML, Mehta SK. Herpes virus reactivation in astronauts during spaceflight and its application on earth. Front Microbiol. (2019) 10:16. 10.3389/fmicb.2019.00016 - DOI - PMC - PubMed

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