Phytochemical analysis and geographic assessment of flavonoids, coumarins and sesquiterpenes in Artemisia annua L. based on HPLC-DAD quantification and LC-ESI-QTOF-MS/MS confirmation - PubMed (original) (raw)
Phytochemical analysis and geographic assessment of flavonoids, coumarins and sesquiterpenes in Artemisia annua L. based on HPLC-DAD quantification and LC-ESI-QTOF-MS/MS confirmation
Chunqing Fu et al. Food Chem. 2020.
Abstract
To evaluate the quality of Artemisia annua L., an accurate HPLC-DAD method has been developed, validated and applied to the simultaneous quantification of five flavonoids, two coumarins and four sesquiterpenes. An LC-ESI-QTOF-MS/MS confirmation method has been utilized to avoid false-positive results. Principal component analysis and hierarchical cluster analysis results indicated that their contents had obvious regional characteristics. Samples with high contents of artemisinin (8.24 ± 2.92 mg/g) and isorhamnetin (0.28 ± 0.25 mg/g) are mainly distributed south of the Yangtze River, and samples with high contents of scopolin (0.46 ± 0.22 mg/g), scopoletin (1.05 ± 0.17 mg/g), chrysosplenol D (0.64 ± 0.14 mg/g), casticin (1.07 ± 0.23 mg/g), arteannuin B (0.69 ± 0.18 mg/g) and artemisinic acid (3.02 ± 1.00 mg/g) are mainly distributed in eastern and northern China. Geographic content differences of the components in A. annua indicate the potential differences in the health-promoting effects of its clinical application.
Keywords: Artemisia annua L.; Artemisinin; Casticin; Chrysosplenol D; HPLC-DAD; Isorhamnetin; Scopoletin; Scopolin.
Copyright © 2019 Elsevier Ltd. All rights reserved.
Similar articles
- Differences in chemical constituents of Artemisia annua L from different geographical regions in China.
Zhang X, Zhao Y, Guo L, Qiu Z, Huang L, Qu X. Zhang X, et al. PLoS One. 2017 Sep 7;12(9):e0183047. doi: 10.1371/journal.pone.0183047. eCollection 2017. PLoS One. 2017. PMID: 28880869 Free PMC article. - Simultaneous analysis of artemisinin and flavonoids of several extracts of Artemisia annua L. obtained from a commercial sample and a selected cultivar.
Bilia AR, Melillo de Malgalhaes P, Bergonzi MC, Vincieri FF. Bilia AR, et al. Phytomedicine. 2006 Jul;13(7):487-93. doi: 10.1016/j.phymed.2006.01.008. Epub 2006 Feb 20. Phytomedicine. 2006. PMID: 16488585 - Effects of sesquiterpene, flavonoid and coumarin types of compounds from Artemisia annua L. on production of mediators of angiogenesis.
Zhu XX, Yang L, Li YJ, Zhang D, Chen Y, Kostecká P, Kmoníčková E, Zídek Z. Zhu XX, et al. Pharmacol Rep. 2013;65(2):410-20. doi: 10.1016/s1734-1140(13)71016-8. Pharmacol Rep. 2013. PMID: 23744425 - Chrysosplenol d, a Flavonol from Artemisia annua, Induces ERK1/2-Mediated Apoptosis in Triple Negative Human Breast Cancer Cells.
Lang SJ, Schmiech M, Hafner S, Paetz C, Werner K, El Gaafary M, Schmidt CQ, Syrovets T, Simmet T. Lang SJ, et al. Int J Mol Sci. 2020 Jun 8;21(11):4090. doi: 10.3390/ijms21114090. Int J Mol Sci. 2020. PMID: 32521698 Free PMC article. - Simultaneous Quantification of Five Sesquiterpene Components after Ultrasound Extraction in Artemisia annua L. by an Accurate and Rapid UPLC⁻PDA Assay.
Ruan J, Liu Z, Qiu F, Shi H, Wang M. Ruan J, et al. Molecules. 2019 Apr 18;24(8):1530. doi: 10.3390/molecules24081530. Molecules. 2019. PMID: 31003442 Free PMC article.
Cited by
- Antiviral and Immunomodulation Effects of Artemisia.
Kshirsagar SG, Rao RV. Kshirsagar SG, et al. Medicina (Kaunas). 2021 Feb 27;57(3):217. doi: 10.3390/medicina57030217. Medicina (Kaunas). 2021. PMID: 33673527 Free PMC article. Review. - Artemisia annua, a Traditional Plant Brought to Light.
Septembre-Malaterre A, Lalarizo Rakoto M, Marodon C, Bedoui Y, Nakab J, Simon E, Hoarau L, Savriama S, Strasberg D, Guiraud P, Selambarom J, Gasque P. Septembre-Malaterre A, et al. Int J Mol Sci. 2020 Jul 15;21(14):4986. doi: 10.3390/ijms21144986. Int J Mol Sci. 2020. PMID: 32679734 Free PMC article. Review. - Artemisia annua L. polysaccharide improves the growth performance and intestinal barrier function of broilers challenged with Escherichia coli.
Guo S, Shi B, Xing Y, Xu Y, Jin X, Hong L, Zhang S, Qiao M, Yan S. Guo S, et al. Front Microbiol. 2024 Apr 30;15:1390815. doi: 10.3389/fmicb.2024.1390815. eCollection 2024. Front Microbiol. 2024. PMID: 38746748 Free PMC article. - Research Progress on Extraction and Detection Technologies of Flavonoid Compounds in Foods.
Li W, Zhang X, Wang S, Gao X, Zhang X. Li W, et al. Foods. 2024 Feb 19;13(4):628. doi: 10.3390/foods13040628. Foods. 2024. PMID: 38397605 Free PMC article. Review. - Comparative Analysis of Free Amino Acids and Nucleosides in Different Varieties of Mume Fructus Based on Simultaneous Determination and Multivariate Statistical Analyses.
Ou J, Wang R, Li X, Huang L, Yuan Q, Fang C, Wu D. Ou J, et al. Int J Anal Chem. 2020 Aug 1;2020:4767605. doi: 10.1155/2020/4767605. eCollection 2020. Int J Anal Chem. 2020. PMID: 32802060 Free PMC article.