Roles and Functions of Exosomal Non-coding RNAs in Vascular Aging - PubMed (original) (raw)

Review

. 2020 Feb 1;11(1):164-178.

doi: 10.14336/AD.2019.0402. eCollection 2020 Feb.

Affiliations

• PMID: 32010490
• PMCID: PMC6961769
• DOI: 10.14336/AD.2019.0402

Review

Roles and Functions of Exosomal Non-coding RNAs in Vascular Aging

Yu-Qing Ni et al. Aging Dis. 2020.

Abstract

Aging is a progressive loss of physiological integrity and functionality process which increases susceptibility and mortality to diseases. Vascular aging is a specific type of organic aging. The structure and function changes of endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) are the main cause of vascular aging, which could influence the threshold, process, and severity of vascular related diseases. Accumulating evidences demonstrate that exosomes serve as novel intercellular information communicator between cell to cell by delivering variety biologically active cargos, especially exosomal non-coding RNAs (ncRNAs), which are associated with most of aging-related biological and functional disorders. In this review, we will summerize the emerging roles and mechanisms of exosomal ncRNAs in vascular aging and vascular aging related diseases, focusing on the role of exosomal miRNAs and lncRNAs in regulating the functions of ECs and VSMCs. Moreover, the relationship between the ECs and VSMCs linked by exosomes, the potential diagnostic and therapeutic application of exosomes in vascular aging and the clinical evaluation and treatment of vascular aging and vascular aging related diseases will also be discussed.

Keywords: endothelial cells; exosomes; vascular aging; vascular diseases; vascular smooth muscle cells.

Copyright: © 2019 Ni et al.

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Conflict of interest statement

Conflict of interest Not applicable. The authors declare that they have no competing interests.

Figures

Figure 1.

The communication between ECs and VSMCs via exosomal ncRNAs. The blue and brown arrows indicate that exosomal miR206 and miR-143/145 secreted by ECs regulate the functions of VSMCs. The green and purple arrows indicate that exosomal miR-155 and miR-143 secreted by VSMCs regulate the functions of ECs.

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