The pivotal role of TMPRSS2 in coronavirus disease 2019 and prostate cancer - PubMed (original) (raw)

Editorial

. 2020 Sep;16(27):2029-2033.

doi: 10.2217/fon-2020-0571. Epub 2020 Jul 13.

Affiliations

• PMID: 32658591
• PMCID: PMC7359420
• DOI: 10.2217/fon-2020-0571

Editorial

The pivotal role of TMPRSS2 in coronavirus disease 2019 and prostate cancer

Veronica Mollica et al. Future Oncol. 2020 Sep.

No abstract available

Keywords: COVID-19; SARS-CoV-2; TMPRSS2; prostate cancer.

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Figures

Figure 1.. Regulation of TMPRSS2 gene transcription and process of severe acute respiratory syndrome coronavirus 2 entry into target cells.

Androgen receptor gene and ACE2 gene are located on Xq12 and Xp22.2, respectively. Testosterone and dihydrotestosterone stimulate androgen receptor activity. Activated androgen receptor regulates transcription of TMPRSS2 gene. TMPRSS2:ERG gene fusion is associated with prostate cancer development. SARS-CoV-2 engages ACE2 as the entry receptor and uses TMPRSS2 for spike protein priming. Serine protease inhibitors, like camostat mesylate, can inhibit TMPRSS2 and partially block SARS-CoV-2 spike protein-driven entry. SARS-CoV-2: Severe acute respiratory syndrome coronavirus 2.

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