Zinc and manganese contents of micro-dissected pancreatic islets of some rodents. A microchemical study in adult and newborn guinea pigs, rats, Chinese hamsters and spiny mice - PubMed (original) (raw)
- PMID: 335757
Zinc and manganese contents of micro-dissected pancreatic islets of some rodents. A microchemical study in adult and newborn guinea pigs, rats, Chinese hamsters and spiny mice
N Havu et al. Acta Endocrinol (Copenh). 1977 Nov.
Abstract
By a flameless atomic absorption spectrophotometry procedure, using a graphite furnace, it was possible to assay the contents of zinc and managanese in micro-dissected pancreatic islets of several rodents. Interest was focused upon the islets of guinea-pigs, due to the fact that guinea-pig insulin lacks a histidine residue in the B10 position of the molecule which normally binds zinc (or other heavy metals) in the hexamer formation, probably involved in the storage of insulin. Both the zinc and manganese contents were too low in the guinea-pig islet parenchyma to be reasonably involved in the storage of insulin in the beta-granules. Instead, it was suggested that guinea-pig insulin, like hagfish insulin, might crystallize without access to zinc or other heavy metals. Low zinc and manganese contents were also observed in newborn and diabetic guinea-pigs. The islet zinc content was high in the Wistar rat, the Chinese hamster, and the spiny mouse. No significant amounts of manganese were found in any of these kinds of islet parenchyma.
Similar articles
- Microchemical assays of glutathione, zinc, cobalt and manganese in micro-dissected areas of the endocrine pancreas in the hagfish, Myxine glutinosa.
Havu N, Lundgren G, Falkmer S. Havu N, et al. Acta Endocrinol (Copenh). 1977 Nov;86(3):561-9. doi: 10.1530/acta.0.0860561. Acta Endocrinol (Copenh). 1977. PMID: 335756 - [Insulin biosynthesis, storage and secretion. 8. Pancreatic-islet tissue and heavy metals--some ultrastructural and experimental observations].
Boquist L, Falkmer S, Havu N, Pihl E. Boquist L, et al. Lakartidningen. 1968 Sep 11;65(37):3603-7. Lakartidningen. 1968. PMID: 4911711 Swedish. No abstract available. - Energy dispersive X-ray microanalysis of zinc and calcium in organelles of insulin-producing cells of the mouse, rat, and a fish.
Falkmer S, Odselius R, Blondel B, Prentki M, Wollheim CB. Falkmer S, et al. Biomed Biochim Acta. 1985;44(1):37-43. Biomed Biochim Acta. 1985. PMID: 3888207 - The biochemical phylogeny of guinea-pigs and gundis, and the paraphyly of the order rodentia.
Graur D, Hide WA, Zharkikh A, Li WH. Graur D, et al. Comp Biochem Physiol B. 1992 Apr;101(4):495-8. doi: 10.1016/0305-0491(92)90327-n. Comp Biochem Physiol B. 1992. PMID: 1611868 Review.
Cited by
- Evidence that Evolution of the Diabetes Susceptibility Gene SLC30A8 that Encodes the Zinc Transporter ZnT8 Drives Variations in Pancreatic Islet Zinc Content in Multiple Species.
Bosma KJ, Syring KE, Oeser JK, Lee JD, Benninger RKP, Pamenter ME, O'Brien RM. Bosma KJ, et al. J Mol Evol. 2019 Jul;87(4-6):147-151. doi: 10.1007/s00239-019-09898-0. Epub 2019 Jul 4. J Mol Evol. 2019. PMID: 31273433 Free PMC article. - Genetic, Functional, and Immunological Study of ZnT8 in Diabetes.
Huang Q, Du J, Merriman C, Gong Z. Huang Q, et al. Int J Endocrinol. 2019 Feb 26;2019:1524905. doi: 10.1155/2019/1524905. eCollection 2019. Int J Endocrinol. 2019. PMID: 30936916 Free PMC article. Review. - The Diabetes Susceptibility Gene SLC30A8 that Encodes the Zinc Transporter ZnT8 is a Pseudogene in Guinea Pigs Potentially Contributing to Low Guinea Pig Islet Zinc Content.
Syring KE, Bosma KJ, Oeser JK, Shiota M, O'Brien RM. Syring KE, et al. J Mol Evol. 2018 Dec;86(9):613-617. doi: 10.1007/s00239-018-9873-5. Epub 2018 Nov 3. J Mol Evol. 2018. PMID: 30392157 Free PMC article. - Crosstalk between zinc and free fatty acids in plasma.
Coverdale JPC, Khazaipoul S, Arya S, Stewart AJ, Blindauer CA. Coverdale JPC, et al. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Apr;1864(4):532-542. doi: 10.1016/j.bbalip.2018.09.007. Epub 2018 Sep 25. Biochim Biophys Acta Mol Cell Biol Lipids. 2019. PMID: 30266430 Free PMC article. Review. - Role of Zinc Homeostasis in the Pathogenesis of Diabetes and Obesity.
Fukunaka A, Fujitani Y. Fukunaka A, et al. Int J Mol Sci. 2018 Feb 6;19(2):476. doi: 10.3390/ijms19020476. Int J Mol Sci. 2018. PMID: 29415457 Free PMC article. Review.