Phosphorylation affects the ability of tau protein to promote microtubule assembly - PubMed (original) (raw)
. 1984 Apr 25;259(8):5301-5.
- PMID: 6425287
Free article
Phosphorylation affects the ability of tau protein to promote microtubule assembly
G Lindwall et al. J Biol Chem. 1984.
Free article
Abstract
Tau is a family of closely related proteins known for its ability to copolymerize with tubulin, inducing the formation of microtubules. When tau was stripped of phosphate by treatment with alkaline phosphatase it underwent a pronounced change in electrophoretic mobility, probably reflecting a conformational change. The dephosphorylated tau promoted significantly more rapid and more extensive polymerization of microtubules though there was no obvious difference in the microtubules formed. Partially purified microtubule protein contains a kinase that can rephosphorylate tau.
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