Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase - PubMed (original) (raw)

. 1995 Apr;121(4):1053-63.

doi: 10.1242/dev.121.4.1053.

Affiliations

• PMID: 7743921
• DOI: 10.1242/dev.121.4.1053

Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase

T Xu et al. Development. 1995 Apr.

Abstract

We have identified recessive overproliferation mutations by screening and examining clones of mutant cells in genetic mosaics of the fruitfly Drosophila melanogaster. This type of screen provides a powerful approach for identifying and studying potential tumor suppressors. One of the identified genes, lats, has been cloned and encodes a putative protein kinase that shares high levels of sequence similarity with three proteins in budding yeast and Neurospora that are involved in regulation of the cell cycle and growth. Mutations in lats cause dramatic overproliferation phenotypes and various developmental defects in both mosaic animals and homozygous mutants.

PubMed Disclaimer

Similar articles

• Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity.
  Tao W, Zhang S, Turenchalk GS, Stewart RA, St John MA, Chen W, Xu T. Tao W, et al. Nat Genet. 1999 Feb;21(2):177-81. doi: 10.1038/5960. Nat Genet. 1999. PMID: 9988268
• The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation.
  Justice RW, Zilian O, Woods DF, Noll M, Bryant PJ. Justice RW, et al. Genes Dev. 1995 Mar 1;9(5):534-46. doi: 10.1101/gad.9.5.534. Genes Dev. 1995. PMID: 7698644
• A genetic screen for modifiers of the lats tumor suppressor gene identifies C-terminal Src kinase as a regulator of cell proliferation in Drosophila.
  Stewart RA, Li DM, Huang H, Xu T. Stewart RA, et al. Oncogene. 2003 Sep 25;22(41):6436-44. doi: 10.1038/sj.onc.1206820. Oncogene. 2003. PMID: 14508523
• Tumor suppressor genes and signal transduction in Drosophila.
  Woods DF, Bryant PJ. Woods DF, et al. Princess Takamatsu Symp. 1994;24:1-13. Princess Takamatsu Symp. 1994. PMID: 8983059 Review.
• The first oncogene in Drosophila melanogaster.
  Baek KH. Baek KH. Mutat Res. 1999 Mar;436(2):131-6. doi: 10.1016/s1383-5742(98)00027-1. Mutat Res. 1999. PMID: 10095136 Review.

Cited by

• Nuclear receptor E75/NR1D2 promotes tumor malignant transformation by integrating Hippo and Notch pathways.
  Wang X, Guo Y, Lin P, Yu M, Song S, Xu W, Kong D, Wang Y, Zhang Y, Lu F, Xie Q, Ma X. Wang X, et al. EMBO J. 2024 Dec;43(24):6336-6363. doi: 10.1038/s44318-024-00290-3. Epub 2024 Nov 8. EMBO J. 2024. PMID: 39516282 Free PMC article.
• Hippo Signaling Pathway in Colorectal Cancer: Modulation by Various Signals and Therapeutic Potential.
  Mohammadpour S, Torshizi Esfahani A, Sarpash S, Vakili F, Zafarjafarzadeh N, Mashaollahi A, Pardakhtchi A, Nazemalhosseini-Mojarad E. Mohammadpour S, et al. Anal Cell Pathol (Amst). 2024 Oct 11;2024:5767535. doi: 10.1155/2024/5767535. eCollection 2024. Anal Cell Pathol (Amst). 2024. PMID: 39431199 Free PMC article. Review.
• Discovery of selective LATS inhibitors via scaffold hopping: enhancing drug-likeness and kinase selectivity for potential applications in regenerative medicine.
  Issabayeva G, Kang OY, Choi SY, Hyun JY, Park SJ, Jeung HC, Lim HJ. Issabayeva G, et al. RSC Med Chem. 2024 Sep 14;15(12):4080-9. doi: 10.1039/d4md00492b. Online ahead of print. RSC Med Chem. 2024. PMID: 39345719 Free PMC article.
• Hippo effector, Yorkie, is a tumor suppressor in select Drosophila squamous epithelia.
  Bhattacharya R, Kumari J, Banerjee S, Tripathi J, Parihar SS, Mohan N, Sinha P. Bhattacharya R, et al. Proc Natl Acad Sci U S A. 2024 Sep 24;121(39):e2319666121. doi: 10.1073/pnas.2319666121. Epub 2024 Sep 17. Proc Natl Acad Sci U S A. 2024. PMID: 39288176
• Synergistic effect of PAK and Hippo pathway inhibitor combination in NF2-deficient Schwannoma.
  Benton D, Yee Chow H, Karchugina S, Chernoff J. Benton D, et al. PLoS One. 2024 Jul 31;19(7):e0305121. doi: 10.1371/journal.pone.0305121. eCollection 2024. PLoS One. 2024. PMID: 39083549 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Silverchair Information Systems

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • BioCyc
  • FlyBase