Localization of disinhibition-dementia-parkinsonism-amyotrophy complex to 17q21-22 - PubMed (original) (raw)
. 1994 Dec;55(6):1159-65.
Affiliations
- PMID: 7977375
- PMCID: PMC1918447
Localization of disinhibition-dementia-parkinsonism-amyotrophy complex to 17q21-22
K C Wilhelmsen et al. Am J Hum Genet. 1994 Dec.
Abstract
Disinhibition-dementia-parkinsonism-amyotrophy complex (DDPAC) is defined by familial adult-onset behavioral disturbance, followed by frontal lobe dementia, parkinsonism, and amyotrophy in variable proportions. A genetic etiology of DDPAC was suspected because of the familial clustering in family Mo, despite their wide geographic distribution. We have mapped the DDPAC locus to a 12-cM (sex averaged) region between D17S800 and D17S787 on chromosome 17q21-22. The basis for the variability of the clinical findings and pathology in DDPAC is unknown but suggests that the DDPAC locus should be screened as a candidate locus in family studies of conditions with behavioral abnormalities and neurological degeneration.
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References
- Am J Hum Genet. 1988 Mar;42(3):498-505 - PubMed
- Neuron. 1993 Oct;11(4):565-74 - PubMed
- Nat Genet. 1993 Dec;5(4):386-91 - PubMed
- Neurology. 1994 Oct;44(10):1878-84 - PubMed
- Annu Rev Med. 1988;39:193-201 - PubMed
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