Dietary vitamin E modulation of cytokine production by splenocytes and thymocytes from alcohol-fed mice - PubMed (original) (raw)

Dietary vitamin E modulation of cytokine production by splenocytes and thymocytes from alcohol-fed mice

Y Wang et al. Alcohol Clin Exp Res. 1994 Apr.

Abstract

As vitamin E enhances immune responses, it may reduce dietary ethanol (EtOH)-induced immune suppression, thereby favorably affecting host disease resistance. The effects of dietary vitamin E at higher level in alcohol-fed female C57BL/6 mice was determined via in vitro cytokine production by splenocytes and thymocytes, and some other immune functions. A 15-fold increase of vitamin E (160 IU/liter) in a liquid diet (National Council Research), with or without EtOH (4.5%, v/v), was fed to mice for 10 weeks. Vitamin E supplementation restored production of interleukin-2, -5, -6, -10, and interferon-gamma by concanavalin A (Con A)-stimulated splenocytes and interleukin-6 and tumor necrosis factor-alpha by lipopolysaccharide-stimulated splenocytes, which were suppressed by dietary EtOH. However, it had no effect on interleukin-4 secretion, which was also reduced by splenocytes from EtOH-fed mice. Vitamin E supplementation also restored EtOH-suppressed, mitogen-induced splenocyte proliferation, but not thymocyte proliferation, although it slightly increased production of immunoglobulin A and G by lipopolysaccharide-stimulated splenocytes, which were suppressed by dietary EtOH. Dietary vitamin E, furthermore, significantly increased interleukin-2 and -6 secretion by Con A-stimulated thymocytes, which were suppressed by dietary EtOH, although it had no effect on interleukin-4 and interferon-gamma production by Con A-stimulated thymocytes from EtOH-fed mice. These data suggest that dietary vitamin E supplementation can modulate dysregulation of cytokines initiated by dietary EtOH and restore immune dysfunctions induced by EtOH ingestion.

PubMed Disclaimer

Cited by

Vitamin E supplementation does not prevent ethanol-reduced hepatic retinoic acid levels in rats.
Chung J, Veeramachaneni S, Liu C, Mernitz H, Russell RM, Wang XD. Chung J, et al. Nutr Res. 2009 Sep;29(9):664-70. doi: 10.1016/j.nutres.2009.09.008. Nutr Res. 2009. PMID: 19854382 Free PMC article.
Why don't we give chest patients dietary advice?
Devereux G, Seaton A. Devereux G, et al. Thorax. 2001 Sep;56 Suppl 2(Suppl 2):ii15-22. Thorax. 2001. PMID: 11514702 Free PMC article. Review. No abstract available.
Chronic alcohol feeding inhibits atherogenesis in C57BL/6 hyperlipidemic mice.
Emeson EE, Manaves V, Singer T, Tabesh M. Emeson EE, et al. Am J Pathol. 1995 Dec;147(6):1749-58. Am J Pathol. 1995. PMID: 7495299 Free PMC article.

Dietary vitamin E modulation of cytokine production by splenocytes and thymocytes from alcohol-fed mice - PubMed (original) (raw)