The ichthyosis mouse: histologic, histochemical, ultrastructural, and autoradiographic studies of interfollicular epidermis - PubMed (original) (raw)
The ichthyosis mouse: histologic, histochemical, ultrastructural, and autoradiographic studies of interfollicular epidermis
J E Jensen et al. J Invest Dermatol. 1977 Jan.
Free article
Abstract
Interfollicular epidermis from back and tail of the recessive mutant mouse ichthyosis (ic/ic) was studied by histologic, histochemical, ultrastructural, and autoradiographic techniques and compared to heterozygous and Swiss S mouse epidermis. In the ic/ic mouse the stratum corneum was thickened, the granular layer prominent, and the stratum spinosum hyperplastic. Staining reactions for certain respiratory and lysosomal enzymes were more pronounced in epidermis of both back and tail. Ultrastructural studies of ic/ic epidermis demonstrated excessively clumped tonofilaments and increased numbers of mitochondria, ribonuclear protein particles, and membrane-coating granules in the stratum spinosum cells. Dilated intercellular junctions between the stratum spinosum and stratum granulosum cells were packed with membrane-coating and amorphous material. Profuse keratin-forming structures, abnormally large keratohyaline granules, and persistent mitochondria were seen in the stratum granulosum cells. In the stratum corneum, inclusions were prominent and persisted into the upper layers of cells, which were irregular in outline and greatly thickened. No differences in epidermal cell transit time or labeling index were demonstrated among the three types of mice.
Similar articles
- Autosomal-dominant lamellar ichthyosis: ultrastructural characteristics of a new type of congenital ichthyosis.
Kolde G, Happle R, Traupe H. Kolde G, et al. Arch Dermatol Res. 1985;278(1):1-5. doi: 10.1007/BF00412487. Arch Dermatol Res. 1985. PMID: 4096524 - Stratum corneum lipids in disorders of cornification. Steroid sulfatase and cholesterol sulfate in normal desquamation and the pathogenesis of recessive X-linked ichthyosis.
Elias PM, Williams ML, Maloney ME, Bonifas JA, Brown BE, Grayson S, Epstein EH Jr. Elias PM, et al. J Clin Invest. 1984 Oct;74(4):1414-21. doi: 10.1172/JCI111552. J Clin Invest. 1984. PMID: 6592175 Free PMC article. - Retinoid effects on the epidermis.
Elias PM. Elias PM. Dermatologica. 1987;175 Suppl 1:28-36. doi: 10.1159/000248851. Dermatologica. 1987. PMID: 3319727 Review. - Epidermal Barrier Development via Corneoptosis: A Unique Form of Cell Death in Stratum Granulosum Cells.
Matsui T. Matsui T. J Dev Biol. 2023 Nov 30;11(4):43. doi: 10.3390/jdb11040043. J Dev Biol. 2023. PMID: 38132711 Free PMC article. Review.
Cited by
- Promotion of Intestinal Epithelial Cell Turnover by Commensal Bacteria: Role of Short-Chain Fatty Acids.
Park JH, Kotani T, Konno T, Setiawan J, Kitamura Y, Imada S, Usui Y, Hatano N, Shinohara M, Saito Y, Murata Y, Matozaki T. Park JH, et al. PLoS One. 2016 May 27;11(5):e0156334. doi: 10.1371/journal.pone.0156334. eCollection 2016. PLoS One. 2016. PMID: 27232601 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases