Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction - PubMed (original) (raw)

. 1996 Dec 5;384(6608):432-8.

doi: 10.1038/384432a0.

Affiliations

• PMID: 8945469
• DOI: 10.1038/384432a0

Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

E J Wiertz et al. Nature. 1996.

Abstract

The human cytomegalovirus genome encodes proteins that trigger destruction of newly synthesized major histocompatibility complex (MHC) class I molecules. The human cytomegalovirus gene US2 specifies a product capable of dislocating MHC class I molecules from the endoplasmic reticulum to the cytosol and delivering them to the proteasome. This process involves the Sec61 complex, in what appears to be a reversal of the reaction by which it translocates nascent chains into the endoplasmic reticulum.

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Comment in

• Reversal of fortune for nascent proteins.
  Bonifacino JS. Bonifacino JS. Nature. 1996 Dec 5;384(6608):405-6. doi: 10.1038/384405a0. Nature. 1996. PMID: 8945460 No abstract available.

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