Bcl-2 family proteins - PubMed (original) (raw)
Review
. 1998 Dec 24;17(25):3225-36.
doi: 10.1038/sj.onc.1202591.
Affiliations
- PMID: 9916985
- DOI: 10.1038/sj.onc.1202591
Review
Bcl-2 family proteins
J C Reed. Oncogene. 1998.
Abstract
Bcl-2 family proteins serve as critical regulators of pathways involved in apoptosis, acting to either inhibit or promote cell death. Altered expression of these proteins occurs commonly in human cancers, contributing to neoplastic cell expansion by suppressing programmed cell death and extending tumor cell life span. Moreover, because chemotherapeutic drugs typically exert their cytotoxic actions by inducing apoptosis, the ultimate efficacy of most anticancer drugs can be heavily influenced by the relative levels and state of activation of members of the Bcl-2 family. The question of how Bcl-2 family proteins function remains debatable, but new findings are shaping our impressions of these multi-functional proteins and revealing the details of how these proteins participate in the regulation of cell life and death.
Similar articles
- Cell death regulation by the Bcl-2 protein family in the mitochondria.
Tsujimoto Y. Tsujimoto Y. J Cell Physiol. 2003 May;195(2):158-67. doi: 10.1002/jcp.10254. J Cell Physiol. 2003. PMID: 12652643 Review. - The role of the Bcl-2 family in the regulation of outer mitochondrial membrane permeability.
Harris MH, Thompson CB. Harris MH, et al. Cell Death Differ. 2000 Dec;7(12):1182-91. doi: 10.1038/sj.cdd.4400781. Cell Death Differ. 2000. PMID: 11175255 Review. - Control of mitochondrial permeability by Bcl-2 family members.
Sharpe JC, Arnoult D, Youle RJ. Sharpe JC, et al. Biochim Biophys Acta. 2004 Mar 1;1644(2-3):107-13. doi: 10.1016/j.bbamcr.2003.10.016. Biochim Biophys Acta. 2004. PMID: 14996495 Review. - Mitochondria in neutrophil apoptosis.
van Raam BJ, Verhoeven AJ, Kuijpers TW. van Raam BJ, et al. Int J Hematol. 2006 Oct;84(3):199-204. doi: 10.1532/IJH97.06131. Int J Hematol. 2006. PMID: 17050191 Review. - Bcl-2 regulation of mitochondrial energetics.
Murphy E, Imahashi K, Steenbergen C. Murphy E, et al. Trends Cardiovasc Med. 2005 Nov;15(8):283-90. doi: 10.1016/j.tcm.2005.09.002. Trends Cardiovasc Med. 2005. PMID: 16297765 Review.
Cited by
- Unveiling the Mechanism of Protective Effects of Tanshinone as a New Fighter Against Cardiovascular Diseases: A Systematic Review.
Dabbaghi MM, Soleimani Roudi H, Safaei R, Baradaran Rahimi V, Fadaei MR, Askari VR. Dabbaghi MM, et al. Cardiovasc Toxicol. 2024 Dec;24(12):1467-1509. doi: 10.1007/s12012-024-09921-x. Epub 2024 Sep 22. Cardiovasc Toxicol. 2024. PMID: 39306819 Review. - Epstein-Barr Virus Encoded BCL2, BHRF1, Downregulates Autophagy by Noncanonical Binding of BECN1.
Wyatt S, Glover K, Dasanna S, Lewison M, González-García M, Colbert CL, Sinha SC. Wyatt S, et al. Biochemistry. 2023 Oct 17;62(20):2934-2951. doi: 10.1021/acs.biochem.3c00225. Epub 2023 Sep 30. Biochemistry. 2023. PMID: 37776275 Free PMC article. - Berberine induces apoptosis and arrests the cell cycle in multiple cancer cell lines.
Li Q, Zhao H, Chen W, Huang P. Li Q, et al. Arch Med Sci. 2021 Mar 21;19(5):1530-1537. doi: 10.5114/aoms/132969. eCollection 2023. Arch Med Sci. 2021. PMID: 37732040 Free PMC article. - MicroRNAs as the critical regulators of autophagy-mediated cisplatin response in tumor cells.
Tolue Ghasaban F, Maharati A, Akhlaghipour I, Moghbeli M. Tolue Ghasaban F, et al. Cancer Cell Int. 2023 Apr 25;23(1):80. doi: 10.1186/s12935-023-02925-7. Cancer Cell Int. 2023. PMID: 37098542 Free PMC article. Review. - Evaluation of Bax and BCL 2 Genes Polymorphisms in Iraqi Women with Breast Cancer.
Al-Zubaidy HFS, Majeed SR, Al-Koofee DAF. Al-Zubaidy HFS, et al. Arch Razi Inst. 2022 Apr 30;77(2):799-808. doi: 10.22092/ARI.2022.357090.1968. eCollection 2022 Apr. Arch Razi Inst. 2022. PMID: 36284943 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases