PLOS Genetics (original) (raw)
11/07/2024
research article
Contribution of p53-dependent and -independent mechanisms to upregulation of p21 in Fanconi anemia
p21 and ROS cooperate in FA cells to induce replication abnormalities, linking p21 accumulation with S-phase defects and genetic instability.
Image credit: pgen.1011474
11/07/2024
research article
Repeat mediated excision of gene drive elements for restoring wild-type populations
Sequencing confirmed transgene excision by SSA in ~4% of progeny, with wild-type alleles and mutations indicating limited maternal Cas9 RNP deposition, highlighting ReMEDE's potential as a gene drive mitigation strategy.
Image credit: pgen.1011450
11/11/2024
research article
Prediction of causal genes at GWAS loci with pleiotropic gene regulatory effects using sets of correlated instrumental variables
MVMR with dependent, as opposed to independent, sets of instrumental variables significantly expands the scope for predicting causal genes in disease risk loci with pleiotropic regulatory effects.
Image credit: pgen.1011473
Five new journals unified in addressing global health and environmental challenges are now ready to receive submissions: PLOS Climate, PLOS Sustainability and Transformation, PLOS Water, PLOS Digital Health, and PLOS Global Public Health
The COVID-19 Collection highlights all content published across the PLOS journals relating to the COVID-19 pandemic.
PLOS ONE is now accepting submissions of Lab Protocols, a peer-reviewed article collaboration with protocols.io, and Study Protocols, an article that credits the work done prior to producing and publishing results.
A collection of free training and resources for peer reviewers of PLOS journals—and for the peer review community more broadly—drawn from research and interviews with staff editors, editorial board members, and experienced reviewers.
PLOS Computational Biology's "Ten Simple Rules" articles provide quick, concentrated guides for mastering some of the professional challenges research scientists face in their careers.
PLOS Genetics welcomes several new Associate Editors to our board: Nicolas Bierne, Julie Simpson, Yun Li, Hongbin Ji, Hongbing Zhang, Bertrand Servin, & Benjamin Schwessinger
The former Natural Variation section at PLOS Genetics relaunches as Human Genetic Variation and Disease. Read the editors' reasoning behind this change.
Quanjiang Ji (ShanghaiTech University) joined the editorial board and Xiaofeng Zhu (Case Western Reserve University) was promoted as new Section Editors for the PLOS Genetics Methods section.
Congratulations to Associate Editor Michael Lichten and Consulting Editor Nicole King, who are newly elected members of the National Academy of Sciences.
Congratulations to Associate Editor Harmit Malik, who was awarded the Edward Novitski Prize by the Genetics Society of America for his work on genetic conflict. Harmit has also been elected as a new member of the American Academy of Arts & Sciences.