COSMIC - Catalogue of Somatic Mutations in Cancer (original) (raw)

COSMIC v100, released 21-MAY-24

COSMIC, the Catalogue Of Somatic Mutations In Cancer, is the world's largest and most comprehensive resource for exploring the impact of somatic mutations in human cancer.

Start using COSMIC by searching for a gene, cancer type, mutation, etc. below.

Projects

COSMIC is divided into several distinct projects, each presenting a separate dataset or view of our data:

• COSMIC
  The core of COSMIC, an expert-curated database of somatic mutations
• Cell Lines Project
  Mutation profiles of over 1,000 cell lines used in cancer research
• COSMIC-3D
  An interactive view of cancer mutations in the context of 3D structures
• Cancer Gene Census
  A catalogue of genes with mutations that are causally implicated in cancer
• Cancer Mutation Census
  Classification of genetic variants driving cancer
• Actionability
  Mutations actionable in precision oncology

Data curation

• Gene Curation — details of our manual curation process
• Gene Fusion Curation — details of our curation process for gene fusions
• Genome Annotation — information on the annotation of genomes
• Drug Resistance — curation of mutations conferring drug resistance
• Mutational Signatures — a census of mutation signatures in cancer
• Actionability — Mutations actionable in precision oncology

COSMIC News

Follow @cosmic_sanger

Tools

• Cancer Browser — browse COSMIC data by tissue type and histology
• Genome Browser — browse the human genome with COSMIC annotations
• GA4GH Beacon — access COSMIC data through the GA4GH Beacon Project

Help

• Downloads — data that you can download from our SFTP site
• Documentation — view our help documentation
• FAQ — a compilation of our Frequently Asked Questions
• Release Notes — information about the latest COSMIC release
• Licensing — information about our licensing policy