Cancer Genome Project (original) (raw)

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The Cancer Genome Project uses high-throughput genome sequencing to identify these somatically acquired mutations with the aim of characterising cancer genes, mutational processes and patterns of clonal evolution in human tumours.

Cancer is caused by the genetic changes acquired by our cells as we go through life. We use cutting-edge DNA sequencing methods to identify these genetic changes, known as mutations, from human cancer samples. Our aim is to discover the genes that are frequently mutated in tumours, since these provide important insights into the biology of cancer. We also study the patterns of mutations we see in cancer cells. These patterns represent a record of the cancer’s life history, and can illustrate the damaging factors the genome has been exposed to as the cancer has evolved from a normal cell.