Potentiation of hydrocortisone activity in skin by glycyrrhetinic acid (original) (raw)

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Abstract

The enzyme 11 β-hydroxysteroid dehydrogenase (11β-OHSD), which catalyses the conversion of cortisol to the inactive steroid cortisone in man (and corticosterone to 11-dehydrocorticosterone in rodents), was demonstrated by immunohistochemistry in skin biopsy samples from healthy volunteers and from patients with psoriasis and eczema. In-vitro studies confirmed the presence of the enzyme in skin from nude mice and showed that it is inhibited by glycyrrhetinic acid, the major active component of liquorice. By means of the skin vasoconstrictor assay, glycyrrhetinic acid was shown to potentiate the action of hydrocortisone. This work suggests a novel means of targeting glucocorticoid therapy.

References (31)

• Sl Hsia et al.

Metabolic transformations of cortisol-4-[14C] in human skin

Biochemistry

(1966)

• R. Valentino et al.

Liquorice inhibits 11 β-hydroxysteroid dehydrogenase in the rat

J Endocrinol

(1987)

• Kh Burdick

Various vagaries of vasoconstriction

Arch Dermatol

(1974)

• The hazardous jungle of topical steroids

Lancet

(1977)

• R. Brattsand, A. Thalen, K. Roempke, L. Kallstrom, E. Gruvstad, Development of new glucocorticosteroids with a very...

Eur J Respir Dis

(1982)

• Rj Stead et al.

Adverse effects of inhaled corticosteroids

Br Med J

(1989)

• R. Wyatt et al.

Effects of inhaled beclomethasone dipropionate and alternate-day prednisone on pituitary-adrenal function in children with chronic asthma

N Engl J Med

(1978)

• Rb Rhoades et al.

Clinically apparent adrenal suppression with beclomethasone (400 meg/day) inhalation

J Allergy Clin Immunol

(1980)

• Fd Malkinson et al.

In vitro studies of adrenal steroid metabolism in the skin

J Invest Dermatol

(1959)

• Pm Stewart et al.

Mineralocorticoid activity of liquorice: 11β hydroxysteroid dehydrogenase deficiency comes of age

Lancet

(1987)

• A. Du Vivier et al.

An animal model for evaluating the local and systemic effects of topically applied corticosteroids on epidermal DNA synthesis

Br J Dermatol

(1978)

• Aw McKenzie et al.

Methods for comparing percutaneous absorption of steroids

Arch Dermatol

(1962)

• Va Place et al.

Precise evaluation of topically applied corticosteroid potency. Modification of the Stoughton-McKenzie assay

Arch Dermatol

(1970)

• Dm Phillips et al.

Corticosteroid 11 β-dehydrogenase in rat testis

Endocrinology

(1989)

• Jl Guesdon et al.

The use of avidin-biotin interaction in immunoenzymatic techniques

J Hisochem Cytochem

(1979)

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