Epigenetic regulation in alcoholic liver disease (original) (raw)
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World J Gastroenterol. May 28, 2011; 17(20): 2456-2464
Published online May 28, 2011. doi: 10.3748/wjg.v17.i20.2456
Table 1 Histone modifications, enzymes and genes
| Modifications | Enzymes | Target gene transcription |
|---|---|---|
| Acetylation | ||
| H3 | GNAT | Activating |
| H4 | MYST | Activating |
| H3 and H4 | CBP/p300 | Activating |
| Deacetylation | ||
| H3 and H4 | HDACs 1-11 | Silencing |
| Methylation | ||
| H3K4 | Set1 | Activating |
| H3K36 | Set2 | Activating |
| H3K79 | DoT1L | Activating |
| H3K27 | EZH2 | Silencing |
| H3K9 | SUV39H1 | Silencing |
| H4K20 | SUV4-20H1 | Silencing |
| Phosphorylation | ||
| H3S10 | RSK2 | Silencing |
| Methylated CpG | DNMT1, DNMT3a-3b | Silencing |
- Citation: Mandrekar P. Epigenetic regulation in alcoholic liver disease. World J Gastroenterol 2011; 17(20): 2456-2464
- URL: https://www.wjgnet.com/1007-9327/full/v17/i20/2456.htm
- DOI: https://dx.doi.org/10.3748/wjg.v17.i20.2456