Ten years of sorafenib in hepatocellular carcinoma: Are there any predictive and/or prognostic markers? (original) (raw)
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Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 28, 2018; 24(36): 4152-4163
Published online Sep 28, 2018. doi: 10.3748/wjg.v24.i36.4152
Table 2 Predictive and/or prognostic value of biological markers in hepatocellular carcinoma patients
| Biological markers | Predictive value | Prognostic value | Ref. |
|---|---|---|---|
| Serum and plasma proteins | |||
| VEGF-A | No | Uncertain | [4,57] |
| Ang-2 | No | Yes | [4] |
| IGF-1 | No | No | [55] |
| Single nucleotide polymorphisms | |||
| VEGF-A rs2010963 | No | Yes | [65] |
| VEGF-C rs4604006 | No | Yes | [65] |
| eNOS (_eNOS_-786/eNOS VNTR) | No | Yes | [66] |
| Ang-2 rs55633437 | No | Yes | [67] |
| HIF-1 alpha rs12434438 | No | Yes | [68] |
| Amplifications | |||
| VEGF | No | Uncertain | [70] |
| FGF3/FGF4 | No | Uncertain | [71] |
| miRNAs | |||
| miR-425-3p | No | Yes | [74] |
| miR-224 | No | Yes | [75] |
| miR-181a-5p | No | Yes | [77] |
| miR-339-5p | No | Yes | [77] |
| miR-423-5p | No | Yes | [78] |
| miR-10b-3p | No | Yes | [79] |
| miR-221 | No | Uncertain | [76] |
| Tissue biomarker expression | |||
| Phospho-ERK | Uncertain | Uncertain | [81,82] |
| PDGFR-b | No | Yes | [84] |
| c-Met | No | No | [84] |
| VEGFR | No | No | [84] |
| p-c-Jun | No | Yes | [85] |
- Citation: Marisi G, Cucchetti A, Ulivi P, Canale M, Cabibbo G, Solaini L, Foschi FG, De Matteis S, Ercolani G, Valgiusti M, Frassineti GL, Scartozzi M, Casadei Gardini A. Ten years of sorafenib in hepatocellular carcinoma: Are there any predictive and/or prognostic markers? World J Gastroenterol 2018; 24(36): 4152-4163
- URL: https://www.wjgnet.com/1007-9327/full/v24/i36/4152.htm
- DOI: https://dx.doi.org/10.3748/wjg.v24.i36.4152