doi:10.1093/biomet/84.2.429>, Retout S, Comets E, Samson A, Mentré F (2007) <doi:10.1002/sim.2910>, Bazzoli C, Retout S, Mentré F (2009) <doi:10.1002/sim.3573>, Le Nagard H, Chao L, Tenaillon O (2011) <doi:10.1186/1471-2148-11-326>, Combes FP, Retout S, Frey N, Mentré F (2013) <doi:10.1007/s11095-013-1079-3> and Seurat J, Tang Y, Mentré F, Nguyen TT (2021) <doi:10.1016/j.cmpb.2021.106126>.">

PFIM: Population Fisher Information Matrix (original) (raw)

Evaluate or optimize designs for nonlinear mixed effects models using the Fisher Information matrix. Methods used in the package refer to Mentré F, Mallet A, Baccar D (1997) <doi:10.1093/biomet/84.2.429>, Retout S, Comets E, Samson A, Mentré F (2007) <doi:10.1002/sim.2910>, Bazzoli C, Retout S, Mentré F (2009) <doi:10.1002/sim.3573>, Le Nagard H, Chao L, Tenaillon O (2011) <doi:10.1186/1471-2148-11-326>, Combes FP, Retout S, Frey N, Mentré F (2013) <doi:10.1007/s11095-013-1079-3> and Seurat J, Tang Y, Mentré F, Nguyen TT (2021) <doi:10.1016/j.cmpb.2021.106126>.

Version: 7.0
Depends: R (≥ 4.0.0)
Imports: utils, inline, Deriv, methods, deSolve, purrr, stringr, S7, Matrix, ggplot2, Rcpp, RcppArmadillo, pracma, kableExtra, tibble, scales, knitr
Suggests: rmarkdown, testthat (≥ 3.0.0)
Published: 2025-07-02
DOI: 10.32614/CRAN.package.PFIM
Author: Romain Leroux ORCID iD [aut, cre], France Mentré ORCID iD [aut], Jérémy Seurat ORCID iD [ctb]
Maintainer: Romain Leroux
BugReports: https://github.com/packagePFIM/PFIM/issues
License: GPL (≥ 3)
URL: http://www.pfim.biostat.fr/, https://github.com/packagePFIM
NeedsCompilation: no
Citation: PFIM citation info
Materials: NEWS
CRAN checks: PFIM results

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