flowml: A Backend for a 'nextflow' Pipeline that Performs Machine-Learning-Based Modeling of Biomedical Data (original) (raw)

Provides functionality to perform machine-learning-based modeling in a computation pipeline. Its functions contain the basic steps of machine-learning-based knowledge discovery workflows, including model training and optimization, model evaluation, and model testing. To perform these tasks, the package builds heavily on existing machine-learning packages, such as 'caret' <https://github.com/topepo/caret/> and associated packages. The package can train multiple models, optimize model hyperparameters by performing a grid search or a random search, and evaluates model performance by different metrics. Models can be validated either on a test data set, or in case of a small sample size by k-fold cross validation or repeated bootstrapping. It also allows for 0-Hypotheses generation by performing permutation experiments. Additionally, it offers methods of model interpretation and item categorization to identify the most informative features from a high dimensional data space. The functions of this package can easily be integrated into computation pipelines (e.g. 'nextflow' <https://www.nextflow.io/>) and hereby improve scalability, standardization, and re-producibility in the context of machine-learning.

Version:

0.1.3

Depends:

R (≥ 3.5.0)

Imports:

ABCanalysis, caret, data.table, dplyr, fastshap, furrr, future, magrittr, optparse, parallel, purrr, R6, readr, rjson, rlang, rsample, stats, stringr, tibble, tidyr, utils, vip