DoseFinding: Planning and Analyzing Dose Finding Experiments (original) (raw)
The DoseFinding package provides functions for the design and analysis of dose-finding experiments (with focus on pharmaceutical Phase II clinical trials). It provides functions for: multiple contrast tests, fitting non-linear dose-response models (using Bayesian and non-Bayesian estimation), calculating optimal designs and an implementation of the MCPMod methodology (Pinheiro et al. (2014) <doi:10.1002/sim.6052>).
Version:
1.4-1
Imports:
Suggests:
emmeans, numDeriv, Rsolnp, quadprog, parallel, mmrm, multcomp, knitr, rmarkdown, MASS, testthat (≥ 3.0.0), tibble, RBesT, nlme, dplyr, tidyr
Published:
2025-07-09
DOI:
10.32614/CRAN.package.DoseFinding
Author:
Bjoern Bornkamp 
[aut], Jose Pinheiro [aut], Frank Bretz [aut], Ludger Sandig [aut], Marius Thomas [aut, cre], Daniel Sabanes Bove [aut], Novartis Pharma AG [cph, fnd]
Maintainer:
Marius Thomas <marius.thomas at novartis.com>
BugReports:
https://github.com/openpharma/DoseFinding/issues
License:
URL:
https://github.com/openpharma/DoseFinding,https://openpharma.github.io/DoseFinding/
NeedsCompilation:
yes
Materials:
In views:
ClinicalTrials, ExperimentalDesign
CRAN checks: