FastJM: Semi-Parametric Joint Modeling of Longitudinal and Survival Data (original) (raw)

A joint model for large-scale, competing risks time-to-event data with singular or multiple longitudinal biomarkers, implemented with the efficient algorithms developed by Li and colleagues (2022) <doi:10.1155/2022/1362913> and <doi:10.48550/arXiv.2506.12741>. The time-to-event data is modelled using a (cause-specific) Cox proportional hazards regression model with time-fixed covariates. The longitudinal biomarkers are modelled using a linear mixed effects model. The association between the longitudinal submodel and the survival submodel is captured through shared random effects. It allows researchers to analyze large-scale data to model biomarker trajectories, estimate their effects on event outcomes, and dynamically predict future events from patients’ past histories. A function for simulating survival and longitudinal data for multiple biomarkers is also included alongside built-in datasets.

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