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Papers by Sandrine Herbelet

Novel Research Aspects in Medicine and Medical Science Vol. 7

Vlaams Diergeneeskundig Tijdschrift, Feb 20, 2010

Recentelijk was ik de behandelende dierenarts van een pup met diarree. Uit de mest werd Providenc... more Recentelijk was ik de behandelende dierenarts van een pup met diarree. Uit de mest werd Providencia alcalifaciens geïsoleerd. Wat is het pathogeen belang van deze kiem en wat is volgens u het beste antibioticum om deze infectie te bestrijden?

Journal of Personalized Medicine, Jul 18, 2022

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

JAMA Dermatology, Nov 1, 2022

ImportanceThe minimally important difference (MID) represents the point at which a difference in ... more ImportanceThe minimally important difference (MID) represents the point at which a difference in an outcome measure (eg, Dermatology Life Quality Index) is important enough that it warrants a change in treatment, and, to the authors’ knowledge, the robustness and limitations of MIDs have not been thoroughly evaluated in skin diseases. The MID is increasingly used in clinical trials to demonstrate that an intervention is worthwhile for patients; furthermore, MIDs also contribute to sample size calculations in clinical trials, influence treatment guidelines, and can guide clinicians to modify treatment.ObjectiveTo evaluate the credibility and generalization of MIDs for patient-reported outcome measures (PROMs) in skin disorders.Evidence ReviewA systematic search was conducted in PubMed and Embase for all original articles using the MID concept for skin disorders from inception to December 29, 2021. The credibility of MIDs obtained via an anchor-based approach (eg, global rating of change scale) was assessed with a previously developed credibility instrument. The validity of generalizing established MIDs to other patient groups was evaluated based on the diagnosis and the patient characteristics.FindingsA total of 126 articles were selected, and 84 different MIDs were identified for PROMs. A total of 13 of 84 MIDs (15.5%) for PROMs displayed acceptable credibility. The anchors used had varying capacity to assess minimal important changes from a patient’s perspective and were deemed inappropriate for this purpose in 52 of 84 cases (61.9%). Correlations between the anchors and PROMs were frequently not determined (39 of 84; 46.4%). The time interval for anchor questions assessing a change in the experienced disease burden was not optimal for 10 of 32 transition anchors (&gt;3 months), introducing potential recall bias. Previously reported MIDs were widely used to examine relevant changes in other study populations. However, the diagnosis and disease severity were different from the original MID population in 39 of 70 (55.7%) and 45 of 70 (64.3%) cases, respectively.Conclusions and RelevanceIn this scoping review, only a minority of MIDs for PROMs demonstrated sufficient credibility in dermatology. Inappropriate generalization of previously reported MIDs to patient populations with different disease characteristics was found to be a major concern. Furthermore, the study supported the use of multiple anchors and encouraged consistent reporting of the correlation between changes in the anchor and changes in the outcome measures.

Frontiers in Pediatrics

Background and objectivesChildren are more likely to suffer a hypoxic-ischaemic cause for cardiac... more Background and objectivesChildren are more likely to suffer a hypoxic-ischaemic cause for cardiac arrest. Early ventilation may provide an advantage in outcome during paediatric cardiopulmonary resuscitation [CPR]. European Resuscitation Council guidelines recommend five initial rescue breaths [IRB] in infants, stemming from the hypothesis that rescuers might need 5 attempts in order to deliver 2 effective ventilations. This study aimed to verify this hypothesis.MethodsParticipants (n = 112, convenience sample) were medical students from the Faculty of Medicine and Health Sciences Ghent University, Belgium. Students were divided into duos and received a 15 min just-in-time training regarding the full CPR-cycle using BMV. Participants then performed five cycles of 2-person CPR. The IRB were given by 1-person BMV, as opposed to a 2-persons technique during the further CPR-cycle. Correct ventilations for the infant were defined as tidal volumes measured (Laerdal® Q-CPR) between 20 and ...

Journal of Personalized Medicine

Background: Clinician-reported outcome measures (ClinROMs) are frequently used in clinical trials... more Background: Clinician-reported outcome measures (ClinROMs) are frequently used in clinical trials and daily practice to evaluate the disease status and evolution of skin disorders. The minimal important difference (MID) represents the smallest difference that decreases the disease impact enough to make a treatment change worthwhile for patients. As no clear guidance exists on the preferred method to calculate MIDs for ClinROMs, we evaluated how the published values for different skin disorders should be interpreted. Methods: A systematic search was performed for MIDs of ClinROMs that focus on skin disorders and/or symptoms. The results of the questions in the credibility instrument for MIDs of Devji et al., 2020 were analyzed to gain insights into the meaning of these MIDs. Results: 29 MIDs were identified. The most common skin diseases were atopic dermatitis/eczema, followed by bullous disorders and psoriasis. A minimal important difference from the patients’ perspective was determ...

Pigment Cell & Melanoma Research

Several digital image analysis systems have been developed for surface calculation of vitiligo le... more Several digital image analysis systems have been developed for surface calculation of vitiligo lesions. Critical assessment of their measurement properties is crucial to support evidence‐based recommendations on the most suitable instruments and will reveal the need for future research. A systematic review was performed to systematically summarize, compare, and critically assess the measurement properties of digital and analogue analysis systems for surface calculation of vitiligo lesions following the Consensus‐Based Standards for the Selection of Health Measurement Instruments (COSMIN) recommendations. Nineteen clinical trials were selected including 25 different instruments. Manual tracing on transparent sheets (contact planimetry) combined with digital measurement or point counting can be considered as the best validated method for the evaluation of target lesions taking into account the skin curvatures. Two‐dimensional digital imaging analysis on photographs seems also robust a...

Biological membranes act as barriers or reservoirs for many compounds within the human body. As s... more Biological membranes act as barriers or reservoirs for many compounds within the human body. As such, they play an important role in pharmacokinetics and pharmacodynamics of drugs and other molecular species. Until now, most membrane/drug interactions have been inferred from simple partitioning between octanol and water phases. However, the observed variability among membrane composition and among compounds themselves stretches beyond such simplification as there are multiple drug-membrane interactions. Numerous experimental and theoretical approaches are used to determine the molecule-membrane interactions with variable accuracy, but there is no open resource for their critical comparison. For this reason, we have built Molecules on Membranes Database (MolMeDB), which gathers data about over 2000 compound-membrane interactions including partitioning, penetration, and positioning. The data have been collected from scientific articles published in peer-reviewed journals and complemen...

Resuscitation, 2020

The actual severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic highlights the n... more The actual severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic highlights the need for advanced care planning (ACP) in patients affected with coronavirus disease of 2019 (COVID-19) in need for cardiopulmonary resuscitation (CPR) in case of sudden cardiac arrest (SCA) [1]. Primary care physicians (PCP) and specialists with trust bonds with their patients should encourage completion of physician order for life-sustaining treatments (POLST) forms to respect one’s wish in the face of death [1]. These official “Do Not Resuscitate (DNR)” codes are not always respected: a 9.42 % rate of delivered CPR despite a DNR code (52 out of 552 SCA patients) was reported by the National Confidential Enquiry into Patient Outcome and Death in 2012 in the UK. Another study conducted in 2014 in an older and frailer patient population in the UK reported an outcome of 6.06 % (8 out of 132 SCA patients) [2, 3, 4].