Jap Jayasinghe | University of Aberdeen (original) (raw)
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Objectives: To conduct a systematic review of epidemiological literature to determine the inciden... more Objectives: To conduct a systematic review of epidemiological literature to determine the incidence of bisphosphonate related osteonecrosis of the jaw occurring either spontaneously or after dental surgery, in children and adolescents diagnosed with osteogenesis imperfecta. Material and Methods: MEDLINE, HMIC and EMBASE were used to search for English-language articles published from 1946- 2013. Inclusion criteria consisted of population based studies of children and adolescents (24 years and younger) diagnosed with osteogenesis imperfecta, only studies which included a dental examination, and patients treated with intravenous bisphosphonates were included. Articles were excluded if patients had any other co-morbidity which could affect osteonecrosis of the jaw, and those which treated patients with oral bisphosphonates only. Results: Five studies consisting of four retrospective cohort studies and one case series were identified. Study populations ranged from 15 to 278 patients and...
Bone, 1992
Trabecular bone from fourth lumbar vertebral bodies of 30 autopsy subjects (18 male and 12 female... more Trabecular bone from fourth lumbar vertebral bodies of 30 autopsy subjects (18 male and 12 females, 30-91 years of age) was investigated using surface mode scanning electron microscopy. In the younger individuals, proper coupling of formation and resorption appeared to have maintained both the bone mass and the shape and structural integrity of the trabecular elements. In elderly individuals, including osteoporotics, irregularities and uncoupling of these activities brought about a loss of bone and a disruption of trabecular structure. Distinct resorption patterns (lateral and vertical) are responsible for trabecular thinning and removal of structural elements. Irregularities in the formative process in old age may account for the compensatory thickening and changes in shape and texture of trabecular elements. The mechanisms involved in the occurrence of microfractures and the fate of disconnected elements were also identified. An increased proportion of arrested mineralizing fronts is found in older individuals and in frank osteoporotics. Resorption may occur through osteoid and arrested mineralizing fronts, as well as through resting, fully mineralized surfaces.
Journal of oral & maxillofacial research, 2013
To conduct a systematic review of epidemiological literature to determine the incidence of bispho... more To conduct a systematic review of epidemiological literature to determine the incidence of bisphosphonate related osteonecrosis of the jaw occurring either spontaneously or after dental surgery, in children and adolescents diagnosed with osteogenesis imperfecta. MEDLINE, HMIC and EMBASE were used to search for English-language articles published from 1946 - 2013. Inclusion criteria consisted of population based studies of children and adolescents (24 years and younger) diagnosed with osteogenesis imperfecta, only studies which included a dental examination, and patients treated with intravenous bisphosphonates were included. Articles were excluded if patients had any other co-morbidity which could affect osteonecrosis of the jaw, and those which treated patients with oral bisphosphonates only. Five studies consisting of four retrospective cohort studies and one case series were identified. Study populations ranged from 15 to 278 patients and number of subjects with osteogenesis impe...
Objectives: To conduct a systematic review of epidemiological literature to determine the inciden... more Objectives: To conduct a systematic review of epidemiological literature to determine the incidence of bisphosphonate related osteonecrosis of the jaw occurring either spontaneously or after dental surgery, in children and adolescents diagnosed with osteogenesis imperfecta. Material and Methods: MEDLINE, HMIC and EMBASE were used to search for English-language articles published from 1946- 2013. Inclusion criteria consisted of population based studies of children and adolescents (24 years and younger) diagnosed with osteogenesis imperfecta, only studies which included a dental examination, and patients treated with intravenous bisphosphonates were included. Articles were excluded if patients had any other co-morbidity which could affect osteonecrosis of the jaw, and those which treated patients with oral bisphosphonates only. Results: Five studies consisting of four retrospective cohort studies and one case series were identified. Study populations ranged from 15 to 278 patients and...
Bone, 1992
Trabecular bone from fourth lumbar vertebral bodies of 30 autopsy subjects (18 male and 12 female... more Trabecular bone from fourth lumbar vertebral bodies of 30 autopsy subjects (18 male and 12 females, 30-91 years of age) was investigated using surface mode scanning electron microscopy. In the younger individuals, proper coupling of formation and resorption appeared to have maintained both the bone mass and the shape and structural integrity of the trabecular elements. In elderly individuals, including osteoporotics, irregularities and uncoupling of these activities brought about a loss of bone and a disruption of trabecular structure. Distinct resorption patterns (lateral and vertical) are responsible for trabecular thinning and removal of structural elements. Irregularities in the formative process in old age may account for the compensatory thickening and changes in shape and texture of trabecular elements. The mechanisms involved in the occurrence of microfractures and the fate of disconnected elements were also identified. An increased proportion of arrested mineralizing fronts is found in older individuals and in frank osteoporotics. Resorption may occur through osteoid and arrested mineralizing fronts, as well as through resting, fully mineralized surfaces.
Journal of oral & maxillofacial research, 2013
To conduct a systematic review of epidemiological literature to determine the incidence of bispho... more To conduct a systematic review of epidemiological literature to determine the incidence of bisphosphonate related osteonecrosis of the jaw occurring either spontaneously or after dental surgery, in children and adolescents diagnosed with osteogenesis imperfecta. MEDLINE, HMIC and EMBASE were used to search for English-language articles published from 1946 - 2013. Inclusion criteria consisted of population based studies of children and adolescents (24 years and younger) diagnosed with osteogenesis imperfecta, only studies which included a dental examination, and patients treated with intravenous bisphosphonates were included. Articles were excluded if patients had any other co-morbidity which could affect osteonecrosis of the jaw, and those which treated patients with oral bisphosphonates only. Five studies consisting of four retrospective cohort studies and one case series were identified. Study populations ranged from 15 to 278 patients and number of subjects with osteogenesis impe...