Sara MacLennan | University of Aberdeen (original) (raw)

Papers by Sara MacLennan

Nature Reviews Urology

PIONEER is a European network of excellence for big data in prostate cancer consisting of 37 priv... more PIONEER is a European network of excellence for big data in prostate cancer consisting of 37 private and public stakeholders from 9 countries across Europe. Many progresses have been done in prostate cancer management, but unanswered questions in the field still exist, and big data could help to answer these questions. The PIONEER consortium conducted a two-round modified Delphi survey aiming at building consensus between two stakeholder groups-health-care professionals and patients with prostate cancer-about the most important questions in the field of prostate cancer to be answered using big data. Respondents were asked to consider what would be the effect of answering the proposed questions on improving diagnosis and treatment outcomes for patients with prostate cancer and to score these questions on a scale of 1 (not important) to 9 (critically important). The mean percentage of participants who scored each of the proposed questions as critically important was calculated across the two stakeholder groups and used to rank the questions and identify the highest scoring questions in the critically important category. The identification of questions in prostate cancer that are important to various stakeholders will help the PIONEER consortium to provide answers to these questions to improve the clinical care of patients with prostate cancer. Sections disease-related outcomes and health economic outcomes across the European health-care landscape 14. Specific objectives of the PIONEER project include: improving disease understanding and delivering a core set of clinically relevant standardized prostate cancer-related outcomes; optimizing diagnosis and therapeutic management of patients with prostate cancer across different stages of the disease and across

Cadernos de Saúde Pública

Two important aspects must be accounted for when discussing the mental health of first responders... more Two important aspects must be accounted for when discussing the mental health of first responders and, in particular, their report of post-traumatic stress symptoms (PTSS). The first concerns the provision of quantitative data from longitudinal study designs, the second concerns the sophistication of the work-related model used to frame such studies. This is a report on the development of a model for Brazilian firefighters who also work as first responders, from the establishment of a longitudinal panel design study, the Brazilian Firefighter Longitudinal Health Study (FLoHS). The first objective was to compare trainee and active firefighters based on their follow-up data with a nationwide sample of similarly aged Brazilians. The second was to test the effect that operational and organizational experiences had on firefighters' PTSS level during follow up. At baseline, trainee firefighters came from higher socioeconomic backgrounds, were healthier and less exposed to trauma compared to a similarly aged national sample. At follow up, they reported higher prevalence of smoking, sleep problems, anhedonia and were more likely to be overweight. PTSS was predicted by operational and organizational stressors, even when controlled for health status at baseline. The results present not only the differences in the predictive status of operational and organizational events in relation to PTSS, but also how the effects of such events might interact. The data suggest the need for evidence-based interventions, support provided and changes at work environments to improve report rates for mental health in general and for PTSS in particular.

Cancers

Introduction: Patient-reported outcome measures (PROMs) represent important endpoints in metastat... more Introduction: Patient-reported outcome measures (PROMs) represent important endpoints in metastatic prostate cancer (mPCa). However, the clinically valid and accurate measurement of health-related quality of life depends on the psychometric properties of the PROMs considered. Objective: To appraise, compare, and summarize the properties of PROMs in mPCa. Evidence acquisition: We performed a review of PROMs used in RCTs, including patients with mPCa, using Medline in September 2021, according to the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) criteria. This systematic review is part of PIONEER (an IMI2 European network of excellence for big data in PCa). Results: The most frequently used PROMs in RCTs of patients with mPCa were the Functional Assessment for Cancer Therapy—Prostate (FACT-P) (n = 18), the Brief Pain Inventory—Short Form (BPI-SF) (n = 8), and the European Organization for Research and Treatment of Cancer quality of life core 30...

Journal of Personalized Medicine, May 5, 2022

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

BJU International

To assess the cost-effectiveness, resource use implications, quality-adjusted life-years (QALYs) ... more To assess the cost-effectiveness, resource use implications, quality-adjusted life-years (QALYs) and cost per QALY of care pathways starting with either extracorporeal shockwave lithotripsy (SWL) or with ureteroscopic retrieval (ureteroscopy [URS]) for the management of ureteric stones. Patients and Methods Data on quality of life and resource use for 613 patients, collected prospectively in the Therapeutic Interventions for Stones of the Ureter (TISU) randomized controlled trial (ISRCTN 92289221), were used to assess the cost-effectiveness of two care pathways, SWL and URS. A health provider (UK National Health Service) perspective was adopted to estimate the costs of the interventions and subsequent resource use. Quality-of-life data were calculated using a generic instrument, the EuroQol EQ-5D-3L. Results are expressed as incremental cost-effectiveness ratios and cost-effectiveness acceptability curves. Results The mean QALY difference (SWL vs URS) was −0.021 (95% confidence interval [CI] −0.033 to −0.010) and the mean cost difference was −£809 (95% CI −£1061 to −£551). The QALY difference translated into approximately 10 more healthy days over the 6-month period for the patients on the URS care pathway. The probabaility that SWL is cost-effective is 79% at a society's willingness to pay (WTP) threshold for 1 QALY of £30,000 and 98% at a WTP threshold of £20,000. Conclusion The SWL pathway results in lower QALYs than URS but costs less. The incremental cost per QALY is £39 118 cost saving per QALY lost, with a 79% probability that SWL would be considered cost-effective at a WTP threshold for 1 QALY of £30 000 and 98% at a WTP threshold of £20 000. Decision-makers need to determine if costs saved justify the loss in QALYs.

Cancer, Work, and the Quality of Working Life

Wellbeing, 2014

This chapter is concerned with the relationships among cancer survivorship, working life, and wel... more This chapter is concerned with the relationships among cancer survivorship, working life, and wellbeing. It presents a narrative review of the evidence published on this important subject within the framework of the person × environment model, exploring the Accommodation Adaptation Intervention Paradigm being developed by the authors through the METIS Collaboration in the United Kingdom. The focus is on the psychological, social, and organizational issues involved across the patient journey. The review suggests that there is still much to be understood about the successful maintenance of working life in those with cancer and about the respective roles of the key stakeholders, including employing organizations. However, there is much that can be achieved, based on the existing evidence, particularly in relation to the interactions among the stakeholders. Furthermore, what is being learnt here may logically be applied to managing other chronic conditions in relation to working life and wellbeing.

Evidence based urology in practice: heterogeneity in a systematic review meta-analysis

Description of care pathways

Delivering spirituality in maternity services

PD13-07 EVALUATING Patient-Reported Outcomes Measures (Proms) for Localised Prostate Cancer: A Systematic Review Using the Consensus-Based Standard for the Selection of Health Measurement Instruments (Cosmin) Methodology

Journal of Urology, 2021

INTRODUCTION AND OBJECTIVE:Several Patient-Reported Outcome Measures (PROMs) have been proposed f... more INTRODUCTION AND OBJECTIVE:Several Patient-Reported Outcome Measures (PROMs) have been proposed for Localised Prostate Cancer. However, an accurate measurement of Health-Related Quality of Life can...

A systematic review protocol of diagnostic and prognostic factors in patients with prostate cancer

BMJ Open, 2020

The comparative effectiveness of brachytherapy

Cochrane risk-of-bias form for randomised controlled trials

Detailed risk-of-bias and quality assessment

EVOLVE: a framework for meaningful patient involvement in clinical practice guideline development and implementation

Cochrane Database of Systematic Reviews, 2020

Effects of other ablative therapies

Data tables of the salvage review

Cancer survivorship and sustainable working life

Concepts of information provision in cancer care: a critical interpretive synthesis of literature

The comparative effectiveness of high-intensity focused ultrasound