Soraya Parvari | Alborz University of medical Sciences (original) (raw)

Papers by Soraya Parvari

PloS one, Apr 17, 2024

Background Evaluating moral principles in the Society of Medical Sciences and health care workers... more Background Evaluating moral principles in the Society of Medical Sciences and health care workers (HCWs) is imperative due to their direct contact with the community and the significant impact of their attitudes and decisions on people's lives. This study aimed to determine the components related to ethical decisions in medical sciences students. Methods One thousand two hundred thirty-five eligible students in the Alborz University of Medical Sciences participated in this descriptive study. We gathered their socio-demographic information, assessed their moral reasoning, and used the ethical decisions questionnaire, Lutsen moral sensitivity questionnaire, and general health questionnaire (GHQ) for data gathering. The data were analyzed with SPSS software version 25 and LISREL version 8.8. Results According to the path analysis test findings, ethical reasoning significantly correlated with ethical decision-making (B = 0.40). The number of clinical courses passed, moral sensation (moral sensitivity), and the total number of passed academic semesters had the greatest positive and negative association with ethical decision-making, respectively. (B = 0.54), (B = 0.524) and (B =-0.11).

Journal of Sport and Health Science, 2015

Journal of contemporary medical sciences, Jun 26, 2018

Objective Recently growing evident declared that 'neo-oogenesis' continues in mature female life ... more Objective Recently growing evident declared that 'neo-oogenesis' continues in mature female life span and simultaneously another studies confirmed the presence of spermatogonial stem cells (SSCs). Even though there is an agreement between scientist about SSCs population in male gender but on the other side ovarian stem cells have received raising challenges regarding the existence in the surface epithelium of ovary. Mesenchymal stem cells (MSCs) are the most applicable source of stem cells and the common marker of MSCs is Sca-1 so that the purpose of this study was to clarify the incidence of stem cells in the surface epithelium of ovary. Methods Forty C57BL6 mice were sacrificed and the ovary carefully excised from its surrounding fat tissue, after mechanical and enzymatic digestion cells were stained with Sca-1 to estimate the incidence of positive stem cells (SCs) population fluorescence activated cell sorting (FACS). Part of digested cells used for RT-PCR, also histological section prepared for immunohistochemical staining of Sca-1 in ovarian surface epithelium FACS. Results The gene expression of Sca-1 was confirmed in the ovarian tissue. As well, localization of Sca-1 + cells was detected in the germinal layer of ovary and epithelial granular layer of primordial follicles. Moreover, we could successfully isolate the Sca-1 + cells through Conclusion The present work findings confirmed an inclusive stem cell population in the ovary which can be a strong evident for regeneration of ovarian tissue in either purpose of ovulation scar and neo-oogenesis.

Pharmaceutical sciences, Jun 30, 2015

PubMed, Mar 1, 2023

Objectives: Gentamicin-induced nephrotoxicity was used as an experimental model of kidney disease... more Objectives: Gentamicin-induced nephrotoxicity was used as an experimental model of kidney disease. The present study was performed to assess the therapeutic role of cannabidiol (CBD) against gentamicin-induced renal damage. Materials and methods: Forty two male Wistar rats were randomly allocated into 6 groups (n=7), including: (1) Control, (2) Vehicle, (3) Gentamicin-treated group (100 mg/kg/day) for 10 days (GM), (4-6) 3 Gentamicin-CBD-treated groups (2.5, 5, and 10 mg/kg/day) for 10 days (GM+CBD2.5, GM+CBD5, GM+CBD10). Serum levels of BUN and Cr, renal histology as well as real-time qRT-PCR were used to investigate the pattern of changes at different levels. Results: Gentamicin increased serum BUN and Cr (P<0.001), down-regulation of FXR (P<0.001), SOD (P<0.05) and up-regulation of CB1 receptor mRNA (P<0.01). Compared to the control group, CBD at 5 decreased (P<0.05) and at 10 mg/kg/day increased the expression of FXR (P<0.05). Nrf2 expression in CBD groups was increased (P<0.001 vs. GM). The expression of TNF-α compared to the control and GM groups, was significantly increased in CBD2.5 (P<0.01) and CBD10 (P<0.05). Compared to the control, CBD at 2.5 (P<0.01), 5 (P<0.001) and 10 (P<0.001) mg/kg/day significantly increased the expression of CB1R. Up-regulation of CB1R in the GM+CBD5, was significantly higher (P<0.05) than the GM group. Compared to the control group, the most significant increase in CB2 receptor expression was observed at CBD10 (P<0.05). Conclusion: CBD particularly at 10 mg/kg/day might be of significant therapeutic benefit against such renal complications. Activating the FXR/Nrf2 pathway and counteracting the deleterious effects of CB1 receptors via CB2 receptors scale-up could be part of the protective mechanisms of CBD.

DOAJ (DOAJ: Directory of Open Access Journals), Nov 1, 2015

Background: Sertoli cells play a pivotal role in creating microenvironments essential for spermat... more Background: Sertoli cells play a pivotal role in creating microenvironments essential for spermatogonial stem cells (SSCs) self-renewal and commitment to differentiation. Maintenance of SSCs and or induction of in vitro spermiogenesis may provide a therapeutic strategy to treat male infertility. Objective: This study investigated the role of luekemia inhibitory factor (LIF) on the propagation of SSCs and both functions of Sertoli cells on the proliferation and differentiation of these cells. Materials and Methods: SSCs were sorted from the testes of adult male mice by magnetic activated cell sorting and thymus cell antigen 1 antibody. On the other hand, isolated Sertoli cells were enriched using lectin coated plates. SSCs were cultured on Sertoli cells for 7 days in the absence or presence of LIF. The effects of these conditions were evaluated by microscopy and expression of meiotic and post meiotic transcripts by reverse transcriptase polymerase chain reaction. Results: Our data showed that SSCs co-cultured with Sertoli cells in the presence of LIF formed colonies on top of the Sertoli cells. These colonies had alkaline phosphatesase activity and expressed SSCs specific genes. SSCs were enjoyed limited development after the mere removal of LIF, and exhibiting expression of meiotic and postmeiotic transcript and loss of SSCs specific gene expression (p< 0.05). Conclusion: Our findings represent co-culture of SSCs with Sertoli cells provides conditions that may allow efficient proliferation and differentiation of SSCs for male infertility treatment.

Iranian Journal of Basic Medical Sciences, Mar 1, 2023

Archives of Medical Science, 2015

Journal of Contemporary Medical Sciences, 2018

Objective: Recently growing evident declared that 'neo-oogenesis' continues in mature fem... more Objective: Recently growing evident declared that 'neo-oogenesis' continues in mature female life span and simultaneously another studies confirmed the presence of spermatogonial stem cells (SSCs). Even though there is agreement between scientist about SSCs population in male gender but on the other side ovarian stem cells have received raising challenges regarding the existence in the surface epithelium of ovary. Mesenchymal stem cells (MSCs) are the most applicable source of stem cells and the common marker of MSCs is Sca-1 so the purpose of this study was to clarify the incidence of stem cells in the surface epithelium of ovary Methods: forty C57BL6 mice were sacrificed and the ovary carefully excised from its surrounding fat tissue, after mechanical and enzymatic digestion cells were stained with Sca1 to estimate the incidence of positive stem cells (SCs) population fluorescence activated cell sorting (FACS). Part of digested cells used for RT-PCR, also histological sect...

BMC Medical Education, 2021

Background Assessment is a necessary part of training postgraduate medical residents. The impleme... more Background Assessment is a necessary part of training postgraduate medical residents. The implementation of methods located at the “shows how” level of Miller’s pyramid is believed to be more effective than previous conventional tools. In this study, we quantitatively compared electronic and conventional methods in assessing ophthalmology residents. Methods In this retrospective study, eight different conventional methods of assessment including residents’ attendance, logbook, scholarship and research skills, journal club, outpatient department participation, Multiple Choice Question (MCQ), Objective Structured Clinical Examination (OSCE), and professionalism/360-degree (as one complex) were used to assess 24 ophthalmology residents of all grades. Electronic media consisting of an online Patient Management Problem (e-PMP), and modified electronic OSCE (me-OSCE) tests performed 3 weeks later were also evaluated for each of the 24 residents. Quantitative analysis was then performed co...

International Journal of Ayurvedic Medicine, 2019

Background: Low back pain (LBP) is one of the most common and costly chronic diseases in the wor... more Background: Low back pain (LBP) is one of the most common and costly chronic diseases in the world today. The use of herbal medicines based on Colchicum autumnal is one of the solutions recommended by Persian medicine for treatment of LBP. One of these products is Rhazes tablet. This study aimed to determine effect of the Rhazes tablet on LBP pain relief and symptoms. Methods: Fifty patients with chronic LBP, aged 19-59 years old, who had LBP for more than 12 weeks, were enrolled in the study. Patients were randomly divided in to intervention group (n=26) and control group (n=24). The patients in the intervention and control groups were treated with Rhazes tablet + Ibuprofen pearl (400mg) PRN and placebo tablet + Ibuprofen pearl (400mg) PRN, respectively. All patients received one tablet in the first week, 2 tablets in week 2-4 and 3 tablets in week 5-8. Pain severity was measured and recorded using VAS and Roland-Morris Disability Questionnaire for all patients at weeks 0, 4 and 8...

aDepartment of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. ... more aDepartment of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. bResearch Center of Nervous System Stem Cells, Department of Anatomy, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran. cDepartment of Anatomy, School of Medicine, Alborz University of Medical Science, Karaj, Iran. dEndometriosis Research Center, Department of Obstetrics and Gynecology, Rasul-e-Akram Hospital, Iran University of Medical Sciences, Iran. Correspondence to Mehdi Abbasi (email: abbasima@sina.tums.ac.ir). (Submitted: 18 December 2017 – Revised version received: 10 January 2018 – Accepted:15 February 2018– Published online: 26 June 2018)

Iranian journal of reproductive medicine, 2015

Sertoli cells play a pivotal role in creating microenvironments essential for spermatogonial stem... more Sertoli cells play a pivotal role in creating microenvironments essential for spermatogonial stem cells (SSCs) self-renewal and commitment to differentiation. Maintenance of SSCs and or induction of in vitro spermiogenesis may provide a therapeutic strategy to treat male infertility. This study investigated the role of luekemia inhibitory factor (LIF) on the propagation of SSCs and both functions of Sertoli cells on the proliferation and differentiation of these cells. SSCs were sorted from the testes of adult male mice by magnetic activated cell sorting and thymus cell antigen 1 antibody. On the other hand, isolated Sertoli cells were enriched using lectin coated plates. SSCs were cultured on Sertoli cells for 7 days in the absence or presence of LIF. The effects of these conditions were evaluated by microscopy and expression of meiotic and post meiotic transcripts by reverse transcriptase polymerase chain reaction. Our data showed that SSCs co-cultured with Sertoli cells in the pr...

Cellular Reprogramming, 2016

An increasing body of evidence has confirmed existence and function of ovarian stem cells (OSCs).... more An increasing body of evidence has confirmed existence and function of ovarian stem cells (OSCs). In this study, a novel approach on differentiation of OSCs into oocyte-like cells (OLCs) has been addressed. Recently, different methods have been recruited to isolate and describe aspects of OSCs, but newer and more convenient strategies in isolation are still growing. Herein, a morphology-based method was used to isolate OSCs. Cell suspension of mouse neonatal ovaries was cultured and formed colonies were harvested mechanically and cultivated on mouse embryonic fibroblasts. For differentiation induction, colonies transferred on inactive granulosa cells. Results showed that cells in colonies were positive for alkaline phosphatase activity and reverse transcription-polymerase chain reaction (RT-PCR) confirmed the pluripotency characteristics of cells. Immunofluorescence revealed a positive signal for OCT4, DAZL, MVH, and SSEA1 in colonies as well. Results of RT-PCR and immunofluorescence confirmed that some OLCs were generated within the germ stem cell (GSCs) colonies. The applicability of morphological selection for isolation of GSCs was verified. This method is easier and more economic than other techniques. Our results demonstrate that granulosa cells were effective in inducing the differentiation of OSCs into OLCs through direct cell-to-cell contacts.

Journal of Pharmaceutical Research International

Back pain and back problems are one of the most common causes for referring patients to health ca... more Back pain and back problems are one of the most common causes for referring patients to health care specialists that have a large economic cost. Therefore, it is considered necessary to find effective treatment for these patients. For the treatment of back pain, various methods as complementary and alternative medicine and industrial drugs are used; that the efficiency of these medicine methods for treatment of back pain is not without dispute. From a variety of traditional methods for treatment of back pain can be cited: the use of medicinal herbs for example: Aloe vera (Family: Liliaceous), Chamomile (Family: Asteraceae), Rosemary (Family: Peppermint), Ginger (Family: Zingiberaceae), Colchicum (Family: Colchicaceae), Curcuma (Family: Zingiberaceae), and use of Medicinal Methods for example: cupping/hijamat, leech therapy, bloodletting, and gams; therefore, this review was conducted in order to evaluate the effectiveness of these methods which used in traditional remedies for the b...