RCC1 in the Ran Pathway (original) (raw)
Journal Article
,
Department of Molecular Biology, Graduate School of Medical Science, Kyushu University
Maidashi, Higashi-ku, Fukuoka 812
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,
Department of Molecular Biology, Graduate School of Medical Science, Kyushu University
Maidashi, Higashi-ku, Fukuoka 812
Search for other works by this author on:
Department of Molecular Biology, Graduate School of Medical Science, Kyushu University
Maidashi, Higashi-ku, Fukuoka 812
1To whom correspondence should be addressed
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Published:
01 August 1996
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Abstract
RCC1 is a chromosomal protein that functions as a GEF of the nuclear G protein Ran, which GTPase activity is enhanced by RNA1 located in the cytoplasm. RCC1 has no preference for GTP or GDP-bound Ran, so that GTP-Ran formation in vivo is regulated by relative concentrations of GTP/GDP and regulatory proteins interacting with RCC1, Ran, and RNA1. Proteins possessing the special Ran-binding motif have been found to be conserved in species ranging from yeasts to mammalians. The finding of RanBP2/NUP358 clearly indicates the involvement of the Ran pathway in the nuclear pore transport function, in agreement with the finding that both _rcc1_− and _rna1_− show defects in this process. However, loss of RCC1 induces premature initiation of mitosis, resulting in G1 arrest with the micronuclei possessing mitotic condensed chromosomes. How both the cell cycle and nucleocytoplasmic transport are regulated by the RCC1-Ran pathway is a major question.
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© 1996 BY THE JOURNAL OF BIOCHEMISTRY
Topic:
- cell cycle
- nucleocytoplasmic transport
- renal cell carcinoma
- chromosomes
- cytoplasm
- guanosine triphosphate phosphohydrolases
- gtp-binding proteins
- micronucleus
- mitosis
- nuclear pore
- yeasts
- regulatory protein
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