Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-α, in Vivo1 (original) (raw)

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1University College London Medical School (V.M.-A., S.G., A.R., D.R.K., J.S.Y., S.W.C.), London, United Kingdom N19 3UA;

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1University College London Medical School (V.M.-A., S.G., A.R., D.R.K., J.S.Y., S.W.C.), London, United Kingdom N19 3UA;

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1University College London Medical School (V.M.-A., S.G., A.R., D.R.K., J.S.Y., S.W.C.), London, United Kingdom N19 3UA;

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1University College London Medical School (V.M.-A., S.G., A.R., D.R.K., J.S.Y., S.W.C.), London, United Kingdom N19 3UA;

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2St. Luke’s Hospital (J.M.M.), Kansas City, Missouri 64111;

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1University College London Medical School (V.M.-A., S.G., A.R., D.R.K., J.S.Y., S.W.C.), London, United Kingdom N19 3UA;

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3Washington University School of Medicine (S.K.), St. Louis, Missouri 63110

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1University College London Medical School (V.M.-A., S.G., A.R., D.R.K., J.S.Y., S.W.C.), London, United Kingdom N19 3UA;

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Revision received:

19 August 1997

Published:

01 December 1997

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V. Mohamed-Ali, S. Goodrick, A. Rawesh, D. R. Katz, J. M. Miles, J. S. Yudkin, S. Klein, S. W. Coppack, Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-α, in Vivo, The Journal of Clinical Endocrinology & Metabolism, Volume 82, Issue 12, 1 December 1997, Pages 4196–4200, https://doi.org/10.1210/jcem.82.12.4450
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We measured arterio-venous differences in concentrations of tumor necrosis factor-α (TNFα) and interleukin-6 (IL-6) across a sc adipose tissue bed in the postabsorptive state in 39 subjects [22 women and 17 men; median age, 36 yr (interquartile range, 26–48 yr); body mass index, 31.8 kg/m2 (range, 22.3- 38.7 kg/m2); percent body fat, 28.7% (range, 17.6–50.7%)]. A subgroup of 8 subjects had arterio-venous differences measured across forearm muscle. Thirty subjects were studied from late morning to early evening; 19 ate a high carbohydrate meal around 1300 h, and 11 continued to fast. We found a greater than 2-fold increase in IL-6 concentrations across the adipose tissue bed [arterial, 2.27 pg/mL (range, 1.42–3.53 pg/mL); venous, 6.71 pg/mL (range, 3.36–9.62 pg/mL); P < 0.001], but not across forearm muscle. Arterial plasma concentrations of IL-6 correlated significantly with body mass index (Spearman’s r = 0.48; P< 0.01) and percent body fat (Spearman’s r = 0.49; P < 0.01). Subcutaneous adipose tissue IL-6 production increased by the early evening (1800–1900 h) in both subjects who had extended their fasting and those who had eaten. Neither deep forearm nor sc adipose tissue consistently released TNFα[ across adipose tissue: arterial, 1.83 pg/mL (range, 1.36–2.34 pg/mL); venous, 1.85 pg/mL (range, 1.44–2.53 pg/mL); P = NS: across forearm muscle: arterial, 1.22 pg/mL (range, 0.74–2.76 pg/mL); venous, 0.99 pg/mL (range, 0.69–1.70 pg/mL); P = NS]. Although both IL-6 and TNFα are expressed by adipose tissue, our results show that there are important differences in their systemic release. TNFα is not released by this sc depot. In contrast, IL-6 is released from the depot and is thereby able to signal systemically.

Copyright © 1997 by The Endocrine Society

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