Serkan ŞEN | Afyon Kocatepe University (original) (raw)
Supervisors: Prof Sefa CELİK and Web Page Serkan Şen
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Background/aim: Acetylsalicylic acid (ASA) treatment in diabetic patients is very important owing... more Background/aim: Acetylsalicylic acid (ASA) treatment in diabetic patients is very important owing to the increasing hyperactivity
of thrombocytes and atherosclerosis. In several investigations, it was reported that diabetes caused increased coronary artery disease,
cerebrovascular disease, and death. In this study, we aimed to investigate the effect of ASA on osmoregulation, glycemic control, and
some biochemical parameters in rats induced with experimental diabetes type 2.
Materials and methods: Twenty-four rats were randomly divided in four groups: control (I), ASA control (II), diabetic (III), and ASA
diabetic (IV). Diabetes was induced by streptozotocin treatment (30 mg/kg, twice, intraperitoneal injection) in obese rats. ASA (150
mg/kg body weight, orally) was administered for 5 weeks in the ASA control and ASA diabetic groups. Serum electrolytes, creatinine,
albumin, and total protein levels were analyzed with an autoanalyzer. Arginine vasopressin (AVP) and insulin were analyzed by ELISA
techniques.
Results: At the end of the study ASA treatments had decreased the fasting blood glucose levels but had interestingly increased the serum
AVP levels in diabetics rats.
Conclusion: AVP levels were increased 2-fold by ASA treatment in diabetic rats. For the first time in this study, the hypoglycemic effect
of ASA was attributed to an increase in blood volume by AVP levels. This explanation may be a new approach to the literature on this
topic.
Tip 2 Diabetes Mellitus (T2DM) hastalarındaki beta hücre kayıplarının temel nedeninin apoptosis o... more Tip 2 Diabetes Mellitus (T2DM) hastalarındaki beta hücre kayıplarının temel nedeninin apoptosis olduğu düşünülmektedir. Apoptosisin önemi; çeşitli biyolojik olaylarda gereksiz, hasarlı ya da zararlı hücrelerin infamatuvar yanıt olmaksızın yok edilişini sağlamasından ve orgaizmanın iç dengesinin devamlılığına katkıda bulunmasından ileri gelmektedir. β hücreleri yoğun olarak insülin sentezlemesi ve salgılaması nedeniyle sıklıkla ER stresine maruz kalmaktadır. Son yıllardaki çalışmalarda β hücrelerinde Endoplazmik Retikulum (ER)’un apoptotik ölüm sinyallerinin iletilmesinde önemli bir organel olduğu gösterilmiştir. β-hücrelerinde ER stresi aracılı apoptosis üzerine yapılacak çalışmalar diyabet patogenezinde yeni mekanizmaların aydınlatılmasına ve tedavi hedeferinin iyi belirlenmesine ışık tutacaktır.
It was assumed that apoptosis is the main factor in beta cell deaths in type II diabetes. Apoptos... more It was assumed that apoptosis is the main factor in beta cell deaths in type II diabetes. Apoptosis is important owing to eradicate the damaged or harmful cells without infammation in various biological facts. This process is also important for homeostasis of organism. B cells are often exposed to ER stress due to excess insulin secretion. In recent years, it was showed that endoplasmic reticulum was an important organelle in apoptotic signal conduction. Investigations including apoptosis induced ER stress will supply new approaches in to clarify the new mechanisms in diabetic pathogenesis and new treatment strategies in diabetes.
Background/aim: Acetylsalicylic acid (ASA) treatment in diabetic patients is very important owing... more Background/aim: Acetylsalicylic acid (ASA) treatment in diabetic patients is very important owing to the increasing hyperactivity
of thrombocytes and atherosclerosis. In several investigations, it was reported that diabetes caused increased coronary artery disease,
cerebrovascular disease, and death. In this study, we aimed to investigate the effect of ASA on osmoregulation, glycemic control, and
some biochemical parameters in rats induced with experimental diabetes type 2.
Materials and methods: Twenty-four rats were randomly divided in four groups: control (I), ASA control (II), diabetic (III), and ASA
diabetic (IV). Diabetes was induced by streptozotocin treatment (30 mg/kg, twice, intraperitoneal injection) in obese rats. ASA (150
mg/kg body weight, orally) was administered for 5 weeks in the ASA control and ASA diabetic groups. Serum electrolytes, creatinine,
albumin, and total protein levels were analyzed with an autoanalyzer. Arginine vasopressin (AVP) and insulin were analyzed by ELISA
techniques.
Results: At the end of the study ASA treatments had decreased the fasting blood glucose levels but had interestingly increased the serum
AVP levels in diabetics rats.
Conclusion: AVP levels were increased 2-fold by ASA treatment in diabetic rats. For the first time in this study, the hypoglycemic effect
of ASA was attributed to an increase in blood volume by AVP levels. This explanation may be a new approach to the literature on this
topic.
Tip 2 Diabetes Mellitus (T2DM) hastalarındaki beta hücre kayıplarının temel nedeninin apoptosis o... more Tip 2 Diabetes Mellitus (T2DM) hastalarındaki beta hücre kayıplarının temel nedeninin apoptosis olduğu düşünülmektedir. Apoptosisin önemi; çeşitli biyolojik olaylarda gereksiz, hasarlı ya da zararlı hücrelerin infamatuvar yanıt olmaksızın yok edilişini sağlamasından ve orgaizmanın iç dengesinin devamlılığına katkıda bulunmasından ileri gelmektedir. β hücreleri yoğun olarak insülin sentezlemesi ve salgılaması nedeniyle sıklıkla ER stresine maruz kalmaktadır. Son yıllardaki çalışmalarda β hücrelerinde Endoplazmik Retikulum (ER)’un apoptotik ölüm sinyallerinin iletilmesinde önemli bir organel olduğu gösterilmiştir. β-hücrelerinde ER stresi aracılı apoptosis üzerine yapılacak çalışmalar diyabet patogenezinde yeni mekanizmaların aydınlatılmasına ve tedavi hedeferinin iyi belirlenmesine ışık tutacaktır.
It was assumed that apoptosis is the main factor in beta cell deaths in type II diabetes. Apoptos... more It was assumed that apoptosis is the main factor in beta cell deaths in type II diabetes. Apoptosis is important owing to eradicate the damaged or harmful cells without infammation in various biological facts. This process is also important for homeostasis of organism. B cells are often exposed to ER stress due to excess insulin secretion. In recent years, it was showed that endoplasmic reticulum was an important organelle in apoptotic signal conduction. Investigations including apoptosis induced ER stress will supply new approaches in to clarify the new mechanisms in diabetic pathogenesis and new treatment strategies in diabetes.