DEVAJIT NATH | All India Institute of Medical Sciences (original) (raw)

Papers by DEVAJIT NATH

Pediatric Hematology Oncology Journal, Dec 1, 2021

Asian Journal of Transfusion Science, 2021

BACKGROUND: Autoimmune hemolytic anemias (AIHA) are characterized by the destruction of red cells... more BACKGROUND: Autoimmune hemolytic anemias (AIHA) are characterized by the destruction of red cells following the production of autoantibodies directed against them. Although AIHA in children is usually self-limiting, many still succumb to the illness due to delay in the diagnosis and treatment. AIHA in children may be secondary to autoimmune diseases, drugs, or immune deficiencies. Early diagnosis and appropriate immunohematological evaluation can aid in the diagnosis and treatment. OBJECTIVE: To analyze the evaluation, treatment, and outcome of AIHA in children. METHODS: Prospective data of patients aged 0–18 years diagnosed with AIHA between June 2017 and May 2019 were collected. INTERVENTION: Prednisolone was the first-line agent in all; second-line agents included cyclosporine and rituximab. Red cell transfusion was given in those with severe anemia with cardiac decompensation. RESULTS: Eleven patients were diagnosed during the study period. Hemoglobin ranged from 1.2 to 9 g/dl. The initial presentation was severe anemia in 8 children and moderate anemia with thrombocytopenia in 3. The trigger was infection in 5. Polyspecific direct coomb's test (DCT) was positive in 10 patients. 2/10 polyspecific DCT-positive cases on further evaluation had immunoglobulin G (IgG) and C3d positivity, whereas rest 8 had only IgG. One infant was diagnosed with DCT-negative immunoglobulin A-mediated AIHA. 4/11 attained remission following the short course of prednisolone. Cyclosporine was used as the second-line agent in 2 and rituximab was used in 3. Seven children are in sustained remission and off medication. One died within 12 h of diagnosis. CONCLUSION: AIHA is not an uncommon problem in children and can vary in its clinical severity. Early and correct diagnosis helps in deciding appropriate treatment.

World Journal of Clinical Cases, 2015

Facial nerve schwannoma occurring within the parotid gland is a rare tumour. We report a case of ... more Facial nerve schwannoma occurring within the parotid gland is a rare tumour. We report a case of schwannoma within the parotid gland in a young female patient, who underwent ultrasound and magnetic resonance imaging (MRI) and subsequent surgical excision of the lesion. The lesion showed hyperintensity on T2-weighted and diffusion-weighted MRI. There was no adjacent lymphadenopathy. Although hyperintensity on diffusionweighted MRI could suggest malignant tumours, the characteristic "string sign" provided the clue for the diagnosis of schwannoma.

Journal of Laryngology and Otology, Apr 1, 1988

A case of adenoid cystic carcinoma of a ceruminous gland in the external auditory meatus, treated... more A case of adenoid cystic carcinoma of a ceruminous gland in the external auditory meatus, treated by local excision, is presented.

Pediatric Hematology Oncology Journal

The Corona Virus disease (COVID19) is declared as pandemic by WHO on 11 th march 2020. This is an... more The Corona Virus disease (COVID19) is declared as pandemic by WHO on 11 th march 2020. This is an infectious

Asian Journal of Transfusion Science, 2021

BACKGROUND: Autoimmune hemolytic anemias (AIHA) are characterized by the destruction of red cells... more BACKGROUND: Autoimmune hemolytic anemias (AIHA) are characterized by the destruction of red cells following the production of autoantibodies directed against them. Although AIHA in children is usually self-limiting, many still succumb to the illness due to delay in the diagnosis and treatment. AIHA in children may be secondary to autoimmune diseases, drugs, or immune deficiencies. Early diagnosis and appropriate immunohematological evaluation can aid in the diagnosis and treatment. OBJECTIVE: To analyze the evaluation, treatment, and outcome of AIHA in children. METHODS: Prospective data of patients aged 0–18 years diagnosed with AIHA between June 2017 and May 2019 were collected. INTERVENTION: Prednisolone was the first-line agent in all; second-line agents included cyclosporine and rituximab. Red cell transfusion was given in those with severe anemia with cardiac decompensation. RESULTS: Eleven patients were diagnosed during the study period. Hemoglobin ranged from 1.2 to 9 g/dl. The initial presentation was severe anemia in 8 children and moderate anemia with thrombocytopenia in 3. The trigger was infection in 5. Polyspecific direct coomb's test (DCT) was positive in 10 patients. 2/10 polyspecific DCT-positive cases on further evaluation had immunoglobulin G (IgG) and C3d positivity, whereas rest 8 had only IgG. One infant was diagnosed with DCT-negative immunoglobulin A-mediated AIHA. 4/11 attained remission following the short course of prednisolone. Cyclosporine was used as the second-line agent in 2 and rituximab was used in 3. Seven children are in sustained remission and off medication. One died within 12 h of diagnosis. CONCLUSION: AIHA is not an uncommon problem in children and can vary in its clinical severity. Early and correct diagnosis helps in deciding appropriate treatment.

Pediatric Hematology Oncology Journal, 2019

Sri Lanka Journal of Surgery, 2015

Adenoid cystic carcinoma (ACC) of breast is a fairly uncommon malignancy, accounting for 0.1% of ... more Adenoid cystic carcinoma (ACC) of breast is a fairly uncommon malignancy, accounting for 0.1% of all cases of breast carcinomas. Though ductal or lobular breast carcinomas can be multifocal/multicentric, examples of the multifocal breast ACC is sparse. Hereby we report a case of retro-areolar multifocal ACC of the breast in a 36 year old female with typical grade 1 histomorphology. Characterization is important as ACC breast has an excellent prognosis with little chance of lymph node and distant metastases. However, our case metastasized after undergoing wide local excision. This example reminds both the physician and pathologist to consider ACC in the differential diagnosis of retroareolar multicentric/multifocal breast carcinoma and the importance of mastectomy with axillary clearance in all histological grades.

The Malaysian journal of pathology, 2015

Myeloid sarcoma (MS) is an extramedullary solid neoplasm of immature myeloid cells. These tumours... more Myeloid sarcoma (MS) is an extramedullary solid neoplasm of immature myeloid cells. These tumours usually develop in concurrence with or following acute leukemia. The breast is an uncommon site for presentation of this tumour, where it is often misdiagnosed as lymphoma or carcinoma.A 33- year-old female presented with a right breast lump in a private hospital, which was diagnosed as ductal carcinoma on lumpectomy. Subsequently she developed a lump in the left breast and a similar diagnosis of carcinoma was made on biopsy. A left mastectomy was performed. Histopathological examination revealed a tumour composed of mononuclear cells arranged in sheets and cords with round to oval vesicular nuclei and occasional prominent nucleoli. IHC for CK was very weak and focal. The tumour cells were immunonegative for ER, PR, Her2neu,epithelial membrane antigen, e-cadherin, CD3 and CD20. Diffuse immunopositivity for myeloperoxidase, CD34 and CD117 established a diagnosis of myeloid sarcoma. A his...

Acta medica Lituanica, 2013

Background. Our objective is to present a very rare clinical case of intraparotid facial nerve sc... more Background. Our objective is to present a very rare clinical case of intraparotid facial nerve schwannoma that clinically presented as an asymptomatic parotid tumor, mimicking pleomorphic adenoma, and was diagnosed only intraoperatively. Another purpose is to discuss diagnostic possibilities, appropriate planning for the management and predictive outcomes of surgical management. Materials and methods. A clinical case of a patient with an asymptomatic parotid mass diagnosed as a facial nerve schwannoma intraoperatively is presented. The patient’s presentation and the diagnostic procedures, surgery and the follow up procedures are discussed. A review of literature is presented. Conclusions. Intraparotid facial nerve schwannoma is an extremely rare entity and rarely diagnosed preoperatively. Management of intraparotid facial nerve schwannomas (IFNS) is very challenging because the diagnosis is often made intraoperatively and in most cases resection can lead to severe facial nerve (FN) ...

Journal of minimal access surgery, 2014

Migration of Ascaris from intestine into peritoneal cavity is rare and usually presents as acute ... more Migration of Ascaris from intestine into peritoneal cavity is rare and usually presents as acute abdomen. We report a case of 41-year-old male who was admitted for laparoscopic mesh rectopexy for rectal prolapse. During the initial laparoscopy, purulent fluid was seen in pelvis. A complete diagnostic laparoscopy was done. An omental nodule was found, which was excised and extracted in a bag. On histopathology, the omental nodule revealed gravid Ascaris lumbricoides.

Case Reports in Otolaryngology, 2014

A 38-year-old man was diagnosed with malignant peripheral nerve sheath tumour of the maxilla. He ... more A 38-year-old man was diagnosed with malignant peripheral nerve sheath tumour of the maxilla. He was treated with total maxillectomy. Histopathological examination of the resected specimen revealed a close resection margin. The tumour was of high grade with an MIB-1 labelling index of almost 60%. At six weeks following the surgery, he developed local tumour relapse. The patient succumbed to the disease at five months from the time of diagnosis. The present report underlines the locally aggressive nature of malignant peripheral nerve sheath tumour of the maxilla which necessitates an early therapeutic intervention. A complete resection with clear margins is the most important prognostic factor for malignant peripheral nerve sheath tumour in the head and neck region. Adjuvant radiotherapy may be considered to improve the local control. Future research may demarcate the role of targeted therapy for patients with malignant peripheral nerve sheath tumour.

Sangeeta Tripathy1*; BKS Chauhan2; Umesh Shukla3; Devajit Nath4 1Department of Radiology, Super S... more Sangeeta Tripathy1*; BKS Chauhan2; Umesh Shukla3; Devajit Nath4 1Department of Radiology, Super Speciality Paediatric Hospital and Post Graduate Teaching Institute (SSPH&PGTI) Sector-30, Noida, India -201303. 2Retired Radiologist, Dr. BKS Chauhan, Delhi, India. 3Department of Gastroenterology, Super Speciality Paediatric Hospital and Post Graduate Teaching Institute (SSPH&PGTI) Sector30, Noida, India -201303. 4Department of Pathology, Super Speciality Paediatric Hospital and Post Graduate Teaching Institute (SSPH&PGTI) Sector-30, Noida, India -201303.

Journal of Clinical Orthopaedics and Trauma, 2015

ABSTRACT Bizarre paroxysmal osteochondromatous proliferation (BPOP), also called Nora’s lesion, i... more ABSTRACT Bizarre paroxysmal osteochondromatous proliferation (BPOP), also called Nora’s lesion, is a rare lesion usually involving the bones of hand. Very few cases of BPOP affecting the metacarpals are reported in literature. There is a lack of consensus on its treatment given the rare occurrence of the disease. We present a new method of treatment in BPOP involving metacarpals of the hand. It includes partial excision of metacarpal and reconstruction with fibular grafting and metacarpophalangeal (MCP) joint replacement.

Indian journal of pathology & microbiology

Angiomyomatous hamartoma (AMH) is a rare disease with predisposition for inguinal and femoral lym... more Angiomyomatous hamartoma (AMH) is a rare disease with predisposition for inguinal and femoral lymph nodes. Histologically, it is characterized by replacement of lymph nodal parenchyma with irregularly distributed thick walled blood vessels, haphazardly arranged smooth muscle cells, variable amount of fat and fibrous tissue in a sclerotic lymphatic stroma. Few cases have also been reported in popliteal and sub - mandibular location. The exact pathogenesis is still not known. Although this entity is very rare, its recognition is important in discriminating it from other benign and malignant vascular lesions of lymph nodes.

Indian journal of pathology & microbiology

Malignant peripheral nerve sheath tumors (MPNSTs) are uncommon sarcomas that originate from a per... more Malignant peripheral nerve sheath tumors (MPNSTs) are uncommon sarcomas that originate from a peripheral nerve or neurofibroma either spontaneously or in association with neurofibromatosis type 1. MPNSTs account for approximately 5% of all soft tissue malignancies. The tumor is commonly seen in the extremities and trunk. Most of these tumors are high-grade with the potential to recur and metastasize. Common metastatic sites include the lungs, bone, and pleura. Primary intraosseous MPNST is rare, and the diagnosis of intraosseous MPNST, especially in an unusual location is difficult because of its cellular origin, histomorphological similarities with other sarcomas, and bone is the most common site for metastasis. We report an unusual case of MPNST of the calcaneus in a young male.

American Journal of Cancer Case Reports, 2015

Introduction: Lymphoproliferative disorders are well known for their variable presentation. Perip... more Introduction: Lymphoproliferative disorders are well known for their variable presentation. Peripheral T cell lymphoma not otherwise specified (PTCL-NOS) is one subtype which is especially notorious. It has a variable age of onset, predominantly a nodal presentation and immunohistochemistry (IHC) depicting mature T cells. Presentation of case: We share our experience of a 33 year old patient who presented with mediastinal mass with pericardial effusion. However the histopathology revealed PTCL-NOS Conclusion: This case in one of the manifestations of heterogeneity encompassing T cell neoplasms where discordance in clinical and pathological behaviour caused not only diagnostic confusion but also complicated treatment decisions.

Indian Journal of Medical and Paediatric Oncology, 2014

Pediatric Hematology Oncology Journal, Dec 1, 2021

Asian Journal of Transfusion Science, 2021

BACKGROUND: Autoimmune hemolytic anemias (AIHA) are characterized by the destruction of red cells... more BACKGROUND: Autoimmune hemolytic anemias (AIHA) are characterized by the destruction of red cells following the production of autoantibodies directed against them. Although AIHA in children is usually self-limiting, many still succumb to the illness due to delay in the diagnosis and treatment. AIHA in children may be secondary to autoimmune diseases, drugs, or immune deficiencies. Early diagnosis and appropriate immunohematological evaluation can aid in the diagnosis and treatment. OBJECTIVE: To analyze the evaluation, treatment, and outcome of AIHA in children. METHODS: Prospective data of patients aged 0–18 years diagnosed with AIHA between June 2017 and May 2019 were collected. INTERVENTION: Prednisolone was the first-line agent in all; second-line agents included cyclosporine and rituximab. Red cell transfusion was given in those with severe anemia with cardiac decompensation. RESULTS: Eleven patients were diagnosed during the study period. Hemoglobin ranged from 1.2 to 9 g/dl. The initial presentation was severe anemia in 8 children and moderate anemia with thrombocytopenia in 3. The trigger was infection in 5. Polyspecific direct coomb's test (DCT) was positive in 10 patients. 2/10 polyspecific DCT-positive cases on further evaluation had immunoglobulin G (IgG) and C3d positivity, whereas rest 8 had only IgG. One infant was diagnosed with DCT-negative immunoglobulin A-mediated AIHA. 4/11 attained remission following the short course of prednisolone. Cyclosporine was used as the second-line agent in 2 and rituximab was used in 3. Seven children are in sustained remission and off medication. One died within 12 h of diagnosis. CONCLUSION: AIHA is not an uncommon problem in children and can vary in its clinical severity. Early and correct diagnosis helps in deciding appropriate treatment.

World Journal of Clinical Cases, 2015

Facial nerve schwannoma occurring within the parotid gland is a rare tumour. We report a case of ... more Facial nerve schwannoma occurring within the parotid gland is a rare tumour. We report a case of schwannoma within the parotid gland in a young female patient, who underwent ultrasound and magnetic resonance imaging (MRI) and subsequent surgical excision of the lesion. The lesion showed hyperintensity on T2-weighted and diffusion-weighted MRI. There was no adjacent lymphadenopathy. Although hyperintensity on diffusionweighted MRI could suggest malignant tumours, the characteristic "string sign" provided the clue for the diagnosis of schwannoma.

Journal of Laryngology and Otology, Apr 1, 1988

A case of adenoid cystic carcinoma of a ceruminous gland in the external auditory meatus, treated... more A case of adenoid cystic carcinoma of a ceruminous gland in the external auditory meatus, treated by local excision, is presented.

Pediatric Hematology Oncology Journal

The Corona Virus disease (COVID19) is declared as pandemic by WHO on 11 th march 2020. This is an... more The Corona Virus disease (COVID19) is declared as pandemic by WHO on 11 th march 2020. This is an infectious

Asian Journal of Transfusion Science, 2021

BACKGROUND: Autoimmune hemolytic anemias (AIHA) are characterized by the destruction of red cells... more BACKGROUND: Autoimmune hemolytic anemias (AIHA) are characterized by the destruction of red cells following the production of autoantibodies directed against them. Although AIHA in children is usually self-limiting, many still succumb to the illness due to delay in the diagnosis and treatment. AIHA in children may be secondary to autoimmune diseases, drugs, or immune deficiencies. Early diagnosis and appropriate immunohematological evaluation can aid in the diagnosis and treatment. OBJECTIVE: To analyze the evaluation, treatment, and outcome of AIHA in children. METHODS: Prospective data of patients aged 0–18 years diagnosed with AIHA between June 2017 and May 2019 were collected. INTERVENTION: Prednisolone was the first-line agent in all; second-line agents included cyclosporine and rituximab. Red cell transfusion was given in those with severe anemia with cardiac decompensation. RESULTS: Eleven patients were diagnosed during the study period. Hemoglobin ranged from 1.2 to 9 g/dl. The initial presentation was severe anemia in 8 children and moderate anemia with thrombocytopenia in 3. The trigger was infection in 5. Polyspecific direct coomb's test (DCT) was positive in 10 patients. 2/10 polyspecific DCT-positive cases on further evaluation had immunoglobulin G (IgG) and C3d positivity, whereas rest 8 had only IgG. One infant was diagnosed with DCT-negative immunoglobulin A-mediated AIHA. 4/11 attained remission following the short course of prednisolone. Cyclosporine was used as the second-line agent in 2 and rituximab was used in 3. Seven children are in sustained remission and off medication. One died within 12 h of diagnosis. CONCLUSION: AIHA is not an uncommon problem in children and can vary in its clinical severity. Early and correct diagnosis helps in deciding appropriate treatment.

Pediatric Hematology Oncology Journal, 2019

Sri Lanka Journal of Surgery, 2015

Adenoid cystic carcinoma (ACC) of breast is a fairly uncommon malignancy, accounting for 0.1% of ... more Adenoid cystic carcinoma (ACC) of breast is a fairly uncommon malignancy, accounting for 0.1% of all cases of breast carcinomas. Though ductal or lobular breast carcinomas can be multifocal/multicentric, examples of the multifocal breast ACC is sparse. Hereby we report a case of retro-areolar multifocal ACC of the breast in a 36 year old female with typical grade 1 histomorphology. Characterization is important as ACC breast has an excellent prognosis with little chance of lymph node and distant metastases. However, our case metastasized after undergoing wide local excision. This example reminds both the physician and pathologist to consider ACC in the differential diagnosis of retroareolar multicentric/multifocal breast carcinoma and the importance of mastectomy with axillary clearance in all histological grades.

The Malaysian journal of pathology, 2015

Myeloid sarcoma (MS) is an extramedullary solid neoplasm of immature myeloid cells. These tumours... more Myeloid sarcoma (MS) is an extramedullary solid neoplasm of immature myeloid cells. These tumours usually develop in concurrence with or following acute leukemia. The breast is an uncommon site for presentation of this tumour, where it is often misdiagnosed as lymphoma or carcinoma.A 33- year-old female presented with a right breast lump in a private hospital, which was diagnosed as ductal carcinoma on lumpectomy. Subsequently she developed a lump in the left breast and a similar diagnosis of carcinoma was made on biopsy. A left mastectomy was performed. Histopathological examination revealed a tumour composed of mononuclear cells arranged in sheets and cords with round to oval vesicular nuclei and occasional prominent nucleoli. IHC for CK was very weak and focal. The tumour cells were immunonegative for ER, PR, Her2neu,epithelial membrane antigen, e-cadherin, CD3 and CD20. Diffuse immunopositivity for myeloperoxidase, CD34 and CD117 established a diagnosis of myeloid sarcoma. A his...

Acta medica Lituanica, 2013

Background. Our objective is to present a very rare clinical case of intraparotid facial nerve sc... more Background. Our objective is to present a very rare clinical case of intraparotid facial nerve schwannoma that clinically presented as an asymptomatic parotid tumor, mimicking pleomorphic adenoma, and was diagnosed only intraoperatively. Another purpose is to discuss diagnostic possibilities, appropriate planning for the management and predictive outcomes of surgical management. Materials and methods. A clinical case of a patient with an asymptomatic parotid mass diagnosed as a facial nerve schwannoma intraoperatively is presented. The patient’s presentation and the diagnostic procedures, surgery and the follow up procedures are discussed. A review of literature is presented. Conclusions. Intraparotid facial nerve schwannoma is an extremely rare entity and rarely diagnosed preoperatively. Management of intraparotid facial nerve schwannomas (IFNS) is very challenging because the diagnosis is often made intraoperatively and in most cases resection can lead to severe facial nerve (FN) ...

Journal of minimal access surgery, 2014

Migration of Ascaris from intestine into peritoneal cavity is rare and usually presents as acute ... more Migration of Ascaris from intestine into peritoneal cavity is rare and usually presents as acute abdomen. We report a case of 41-year-old male who was admitted for laparoscopic mesh rectopexy for rectal prolapse. During the initial laparoscopy, purulent fluid was seen in pelvis. A complete diagnostic laparoscopy was done. An omental nodule was found, which was excised and extracted in a bag. On histopathology, the omental nodule revealed gravid Ascaris lumbricoides.

Case Reports in Otolaryngology, 2014

A 38-year-old man was diagnosed with malignant peripheral nerve sheath tumour of the maxilla. He ... more A 38-year-old man was diagnosed with malignant peripheral nerve sheath tumour of the maxilla. He was treated with total maxillectomy. Histopathological examination of the resected specimen revealed a close resection margin. The tumour was of high grade with an MIB-1 labelling index of almost 60%. At six weeks following the surgery, he developed local tumour relapse. The patient succumbed to the disease at five months from the time of diagnosis. The present report underlines the locally aggressive nature of malignant peripheral nerve sheath tumour of the maxilla which necessitates an early therapeutic intervention. A complete resection with clear margins is the most important prognostic factor for malignant peripheral nerve sheath tumour in the head and neck region. Adjuvant radiotherapy may be considered to improve the local control. Future research may demarcate the role of targeted therapy for patients with malignant peripheral nerve sheath tumour.

Sangeeta Tripathy1*; BKS Chauhan2; Umesh Shukla3; Devajit Nath4 1Department of Radiology, Super S... more Sangeeta Tripathy1*; BKS Chauhan2; Umesh Shukla3; Devajit Nath4 1Department of Radiology, Super Speciality Paediatric Hospital and Post Graduate Teaching Institute (SSPH&PGTI) Sector-30, Noida, India -201303. 2Retired Radiologist, Dr. BKS Chauhan, Delhi, India. 3Department of Gastroenterology, Super Speciality Paediatric Hospital and Post Graduate Teaching Institute (SSPH&PGTI) Sector30, Noida, India -201303. 4Department of Pathology, Super Speciality Paediatric Hospital and Post Graduate Teaching Institute (SSPH&PGTI) Sector-30, Noida, India -201303.

Journal of Clinical Orthopaedics and Trauma, 2015

ABSTRACT Bizarre paroxysmal osteochondromatous proliferation (BPOP), also called Nora’s lesion, i... more ABSTRACT Bizarre paroxysmal osteochondromatous proliferation (BPOP), also called Nora’s lesion, is a rare lesion usually involving the bones of hand. Very few cases of BPOP affecting the metacarpals are reported in literature. There is a lack of consensus on its treatment given the rare occurrence of the disease. We present a new method of treatment in BPOP involving metacarpals of the hand. It includes partial excision of metacarpal and reconstruction with fibular grafting and metacarpophalangeal (MCP) joint replacement.

Indian journal of pathology & microbiology

Angiomyomatous hamartoma (AMH) is a rare disease with predisposition for inguinal and femoral lym... more Angiomyomatous hamartoma (AMH) is a rare disease with predisposition for inguinal and femoral lymph nodes. Histologically, it is characterized by replacement of lymph nodal parenchyma with irregularly distributed thick walled blood vessels, haphazardly arranged smooth muscle cells, variable amount of fat and fibrous tissue in a sclerotic lymphatic stroma. Few cases have also been reported in popliteal and sub - mandibular location. The exact pathogenesis is still not known. Although this entity is very rare, its recognition is important in discriminating it from other benign and malignant vascular lesions of lymph nodes.

Indian journal of pathology & microbiology

Malignant peripheral nerve sheath tumors (MPNSTs) are uncommon sarcomas that originate from a per... more Malignant peripheral nerve sheath tumors (MPNSTs) are uncommon sarcomas that originate from a peripheral nerve or neurofibroma either spontaneously or in association with neurofibromatosis type 1. MPNSTs account for approximately 5% of all soft tissue malignancies. The tumor is commonly seen in the extremities and trunk. Most of these tumors are high-grade with the potential to recur and metastasize. Common metastatic sites include the lungs, bone, and pleura. Primary intraosseous MPNST is rare, and the diagnosis of intraosseous MPNST, especially in an unusual location is difficult because of its cellular origin, histomorphological similarities with other sarcomas, and bone is the most common site for metastasis. We report an unusual case of MPNST of the calcaneus in a young male.

American Journal of Cancer Case Reports, 2015

Introduction: Lymphoproliferative disorders are well known for their variable presentation. Perip... more Introduction: Lymphoproliferative disorders are well known for their variable presentation. Peripheral T cell lymphoma not otherwise specified (PTCL-NOS) is one subtype which is especially notorious. It has a variable age of onset, predominantly a nodal presentation and immunohistochemistry (IHC) depicting mature T cells. Presentation of case: We share our experience of a 33 year old patient who presented with mediastinal mass with pericardial effusion. However the histopathology revealed PTCL-NOS Conclusion: This case in one of the manifestations of heterogeneity encompassing T cell neoplasms where discordance in clinical and pathological behaviour caused not only diagnostic confusion but also complicated treatment decisions.

Indian Journal of Medical and Paediatric Oncology, 2014