Kartavya Kumar Verma | All India Institute of Medical Sciences (original) (raw)

articles by Kartavya Kumar Verma

Journal of Cancer Research and Therapeutics, 2023

Pleomorphic xanthoastrocytoma (PXA) is a low-grade glioma comprising 1% of all astrocytomas with ... more Pleomorphic xanthoastrocytoma (PXA) is a low-grade glioma comprising 1% of all astrocytomas with an extremely rare anaplastic counterpart usually found in young adults. These tumors are most often cerebral in origin and their presentation in the elderly signifies poor prognosis. As these tumors are an important differential of glioblastoma, diagnosing them accurately is essential for management. We present a 68-year-male with positive cerebellar signs and clinico-radiological impression of cerebellar metastatic deposits, subsequently diagnosed as cerebellar PXA with anaplastic features. The case in discussion is unique in its age, site, and grade of presentation, with key histological features rebuking the clinical and radiological diagnosis of metastasis. The rarity and ambiguous management protocol of these tumors make their documentation an important addition to the existing literature with emphasis on possibility of late presentation and at sites other than the cerebrum.

Frontiers in Health Informatics, 2024

Introduction: Lung cancer is one of the most lethal types of organ-specific cancers. Diagnosis wi... more Introduction: Lung cancer is one of the most lethal types of organ-specific cancers. Diagnosis with a small biopsy is a difficult task for the pathologist. In recent years, the treatment scenario and prognosis for lung cancer have changed depending on the type of cell morphology. This study aims to provide data to help diagnose suspected lung cancer cases as early as possible so they can be treated effectively. Material and Methods: We conducted this prospective observational study in the Department of Pathology and Lab Medicine at the All-India Institute of Medical Sciences in Chhattisgarh, India. We collected our data from case records, demographic profiles, and histomorphological profiles of patients diagnosed with primary lung carcinoma from March 2019 to March 2020. Results: All histopathology samples (N = 48) were taken from small biopsies, and 38 of these were from endobronchial biopsies. The mean age of patients in our study was 58.1 ± 12.2 (mean ± SD). Cough (35/48, 72.95%) and pallor (44/48, 91.76%) were the most common symptom and sign, respectively. Adenocarcinoma (ADC) was the most common morphological type (31/48, 64.5%), and the majority of the patients were nonsmokers (30/48, 62.5%). Furthermore, solid pattern (17/31, 54.83%) was the most common subtype among ADC cases. Conclusion: ADC was the most common morphological subtype. In the region where our study was conducted, most patients were nonsmokers. The clinical profiles of the lung carcinoma patients were similar to those in the previously documented literature. We found that immunohistochemistry is useful in the diagnosis of lung carcinoma in small biopsies.

Indian Journal of Pathology and Oncology, 2023

Lipoma is a well-known and most common soft tissue tumor. But multiple lipomatosis are rare. Also... more Lipoma is a well-known and most common soft tissue tumor. But multiple lipomatosis are rare. Also, syndromic associations were documented. Familial multiple lipomatosis (FML) is an autosomal dominant disorder. It presents as multiple lipomas in the body at specific sites. In presenting case 26-year-old patient complained of multiple swellings in his forearms, both thigh, and anterior abdominal wall for 5 years. A diagnosis of multiple lipomatosis is made by Fine needle aspiration cytology and confirmed by histopathological examination.

Keywords: Familial multiple lipomatosis, FNAC, Histopathology, Pathology, Diagnosis

Papers by Kartavya Kumar Verma

Indian J Pathol Microbiology, 2022

Pulmonary tuberculosis is one of the most common immunosuppressive infections in India, seldom ac... more Pulmonary tuberculosis is one of the most common immunosuppressive infections in India, seldom accompanies other parasitic and fungal infections. In our case, we describe the three coexistent infections and their clinical presentation in a 53-year-old woman. A fibro-cavitary lesion in lung with superadded infections of hydatid cyst and aspergillus which is rare has been elaborated in the present case.

Tropical Doctor, Sep 27, 2023

Archives of breast cancer, Jan 31, 2024

Background: Solitary fibrous tumors (SFT) are the rare mesenchymal tumors originally described in... more Background: Solitary fibrous tumors (SFT) are the rare mesenchymal tumors originally described in the pleura. SFT of breast is even rarer and to the best of our knowledge about 35 cases are reported to date, including only six malignant SFT cases. Case presentation: We report a case of a 52-year-old lady with a large left breast mass involving all the quadrants. The tumor was diagnosed as malignant SFT in a core needle biopsy which was later confirmed on the resection specimen. Conclusion: Herein, we describe the approach and importance of optimal utilization of immunohistochemistry for diagnosing such rare tumors of the breast, particularly, when clinical presentation, radiology and fine needle aspiration cytology are incongruous.

SN Comprehensive Clinical Medicine, Jan 4, 2022

HbQ India is a rare α-chain structural hemoglobinopathy usually asymptomatic and presents in the ... more HbQ India is a rare α-chain structural hemoglobinopathy usually asymptomatic and presents in the heterozygous form or co-inherited with β-thalassemia trait. Herein, we are reporting the third case of novel association of HbQ India with HbS trait hemoglobinopathy in a 30-year-old young male presented with chief complaints of yellowish discoloration of sclera since 5 years with raised serum bilirubin levels along with pedigree analysis of the family.

Research Square (Research Square), Jul 1, 2021

HbQ India is a rare α-chain structural hemoglobinopathy usually asymptomatic and presents in the ... more HbQ India is a rare α-chain structural hemoglobinopathy usually asymptomatic and presents in the heterozygous form or co-inherited with β-thalassemia trait. Herein, we are reporting the third case of novel association of HbQ India with HbS trait hemoglobinopathy in a 30-year-old young male presented with chief complaints of yellowish discoloration of sclera since 5 years with raised serum bilirubin levels along with pedigree analysis of the family.

Tropical Doctor, Jan 22, 2023

Yellow phosphorus is one of the most commonly used rodenticides in India for household pest contr... more Yellow phosphorus is one of the most commonly used rodenticides in India for household pest control. It is available as pastes containing 2% to 5% of yellow phosphorus. Yellow phosphorous-containing rodenticides are easily available and account for one of the most common causes of suicidal poisoning in India. We describe a case of yellow phosphorus poisoning in a 17-years-old child who recovered from hepatic encephalopathy and showed unique peripheral smear findings in the form of spurious monocytosis and hypergranulosis of these granulocytes.

Journal of Cancer Research and Therapeutics

Pleomorphic xanthoastrocytoma (PXA) is a low-grade glioma comprising 1% of all astrocytomas with ... more Pleomorphic xanthoastrocytoma (PXA) is a low-grade glioma comprising 1% of all astrocytomas with an extremely rare anaplastic counterpart usually found in young adults. These tumors are most often cerebral in origin and their presentation in the elderly signifies poor prognosis. As these tumors are an important differential of glioblastoma, diagnosing them accurately is essential for management. We present a 68-year-male with positive cerebellar signs and clinico-radiological impression of cerebellar metastatic deposits, subsequently diagnosed as cerebellar PXA with anaplastic features. The case in discussion is unique in its age, site, and grade of presentation, with key histological features rebuking the clinical and radiological diagnosis of metastasis. The rarity and ambiguous management protocol of these tumors make their documentation an important addition to the existing literature with emphasis on possibility of late presentation and at sites other than the cerebrum.

IP Journal of Diagnostic Pathology and Oncology

Gaucher's disease is a rare, inherited autosomal recessive metabolic disorder due to deficien... more Gaucher's disease is a rare, inherited autosomal recessive metabolic disorder due to deficiency of enzyme Glucocerebrosidase resulting in deposition of glucosylceramide. Deposition of glucosylceramide in different organs causes dysfunction and is responsible for specific systemic symptoms and signs. In the present cases, the first case was a 24-year-old female who presented with severe weakness with abdominal fullness due to massive splenomegaly. The unicity of the case was anti-nuclear antibody positivity. Although clinical signs and symptoms were classical in this case. The second case was a 20-year-old male who was already diagnosed case of Gaucher's disease but the only complaint was abdominal fullness due to massive splenomegaly. Special stains were play a tremendous role to highlighting Gaucher's cells.

Tropical Doctor

Yellow phosphorus is one of the most commonly used rodenticides in India for household pest contr... more Yellow phosphorus is one of the most commonly used rodenticides in India for household pest control. It is available as pastes containing 2% to 5% of yellow phosphorus. Yellow phosphorous-containing rodenticides are easily available and account for one of the most common causes of suicidal poisoning in India. We describe a case of yellow phosphorus poisoning in a 17-years-old child who recovered from hepatic encephalopathy and showed unique peripheral smear findings in the form of spurious monocytosis and hypergranulosis of these granulocytes.

HbQ India is a rare α-chain structural hemoglobinopathy usually asymptomatic and presents in the ... more HbQ India is a rare α-chain structural hemoglobinopathy usually asymptomatic and presents in the heterozygous form or co-inherited with β-thalassemia trait. Herein, we are reporting the third case of novel association of HbQ India with HbS trait hemoglobinopathy in a 30-years-old young male presented with chief complaints of yellowish discoloration of sclera since 5-years with raised serum bilirubin levels along with pedigree analysis of the family.

Indian Journal of Pathology and Oncology

Lipoma is a well-known and most common soft tissue tumor. But multiple lipomatosis are rare. Also... more Lipoma is a well-known and most common soft tissue tumor. But multiple lipomatosis are rare. Also, syndromic associations were documented. Familial multiple lipomatosis (FML) is an autosomal dominant disorder. It presents as multiple lipomas in the body at specific sites. In presenting case 26-year-old patient complained of multiple swellings in his forearms, both thigh, and anterior abdominal wall for 5 years. A diagnosis of multiple lipomatosis is made by Fine needle aspiration cytology and confirmed by histopathological examination.

Journal of Cancer Research and Therapeutics, 2023

Pleomorphic xanthoastrocytoma (PXA) is a low-grade glioma comprising 1% of all astrocytomas with ... more Pleomorphic xanthoastrocytoma (PXA) is a low-grade glioma comprising 1% of all astrocytomas with an extremely rare anaplastic counterpart usually found in young adults. These tumors are most often cerebral in origin and their presentation in the elderly signifies poor prognosis. As these tumors are an important differential of glioblastoma, diagnosing them accurately is essential for management. We present a 68-year-male with positive cerebellar signs and clinico-radiological impression of cerebellar metastatic deposits, subsequently diagnosed as cerebellar PXA with anaplastic features. The case in discussion is unique in its age, site, and grade of presentation, with key histological features rebuking the clinical and radiological diagnosis of metastasis. The rarity and ambiguous management protocol of these tumors make their documentation an important addition to the existing literature with emphasis on possibility of late presentation and at sites other than the cerebrum.

Frontiers in Health Informatics, 2024

Introduction: Lung cancer is one of the most lethal types of organ-specific cancers. Diagnosis wi... more Introduction: Lung cancer is one of the most lethal types of organ-specific cancers. Diagnosis with a small biopsy is a difficult task for the pathologist. In recent years, the treatment scenario and prognosis for lung cancer have changed depending on the type of cell morphology. This study aims to provide data to help diagnose suspected lung cancer cases as early as possible so they can be treated effectively. Material and Methods: We conducted this prospective observational study in the Department of Pathology and Lab Medicine at the All-India Institute of Medical Sciences in Chhattisgarh, India. We collected our data from case records, demographic profiles, and histomorphological profiles of patients diagnosed with primary lung carcinoma from March 2019 to March 2020. Results: All histopathology samples (N = 48) were taken from small biopsies, and 38 of these were from endobronchial biopsies. The mean age of patients in our study was 58.1 ± 12.2 (mean ± SD). Cough (35/48, 72.95%) and pallor (44/48, 91.76%) were the most common symptom and sign, respectively. Adenocarcinoma (ADC) was the most common morphological type (31/48, 64.5%), and the majority of the patients were nonsmokers (30/48, 62.5%). Furthermore, solid pattern (17/31, 54.83%) was the most common subtype among ADC cases. Conclusion: ADC was the most common morphological subtype. In the region where our study was conducted, most patients were nonsmokers. The clinical profiles of the lung carcinoma patients were similar to those in the previously documented literature. We found that immunohistochemistry is useful in the diagnosis of lung carcinoma in small biopsies.

Indian Journal of Pathology and Oncology, 2023

Lipoma is a well-known and most common soft tissue tumor. But multiple lipomatosis are rare. Also... more Lipoma is a well-known and most common soft tissue tumor. But multiple lipomatosis are rare. Also, syndromic associations were documented. Familial multiple lipomatosis (FML) is an autosomal dominant disorder. It presents as multiple lipomas in the body at specific sites. In presenting case 26-year-old patient complained of multiple swellings in his forearms, both thigh, and anterior abdominal wall for 5 years. A diagnosis of multiple lipomatosis is made by Fine needle aspiration cytology and confirmed by histopathological examination.

Keywords: Familial multiple lipomatosis, FNAC, Histopathology, Pathology, Diagnosis

Indian J Pathol Microbiology, 2022

Pulmonary tuberculosis is one of the most common immunosuppressive infections in India, seldom ac... more Pulmonary tuberculosis is one of the most common immunosuppressive infections in India, seldom accompanies other parasitic and fungal infections. In our case, we describe the three coexistent infections and their clinical presentation in a 53-year-old woman. A fibro-cavitary lesion in lung with superadded infections of hydatid cyst and aspergillus which is rare has been elaborated in the present case.

Tropical Doctor, Sep 27, 2023

Archives of breast cancer, Jan 31, 2024

Background: Solitary fibrous tumors (SFT) are the rare mesenchymal tumors originally described in... more Background: Solitary fibrous tumors (SFT) are the rare mesenchymal tumors originally described in the pleura. SFT of breast is even rarer and to the best of our knowledge about 35 cases are reported to date, including only six malignant SFT cases. Case presentation: We report a case of a 52-year-old lady with a large left breast mass involving all the quadrants. The tumor was diagnosed as malignant SFT in a core needle biopsy which was later confirmed on the resection specimen. Conclusion: Herein, we describe the approach and importance of optimal utilization of immunohistochemistry for diagnosing such rare tumors of the breast, particularly, when clinical presentation, radiology and fine needle aspiration cytology are incongruous.

SN Comprehensive Clinical Medicine, Jan 4, 2022

HbQ India is a rare α-chain structural hemoglobinopathy usually asymptomatic and presents in the ... more HbQ India is a rare α-chain structural hemoglobinopathy usually asymptomatic and presents in the heterozygous form or co-inherited with β-thalassemia trait. Herein, we are reporting the third case of novel association of HbQ India with HbS trait hemoglobinopathy in a 30-year-old young male presented with chief complaints of yellowish discoloration of sclera since 5 years with raised serum bilirubin levels along with pedigree analysis of the family.

Research Square (Research Square), Jul 1, 2021

HbQ India is a rare α-chain structural hemoglobinopathy usually asymptomatic and presents in the ... more HbQ India is a rare α-chain structural hemoglobinopathy usually asymptomatic and presents in the heterozygous form or co-inherited with β-thalassemia trait. Herein, we are reporting the third case of novel association of HbQ India with HbS trait hemoglobinopathy in a 30-year-old young male presented with chief complaints of yellowish discoloration of sclera since 5 years with raised serum bilirubin levels along with pedigree analysis of the family.

Tropical Doctor, Jan 22, 2023

Yellow phosphorus is one of the most commonly used rodenticides in India for household pest contr... more Yellow phosphorus is one of the most commonly used rodenticides in India for household pest control. It is available as pastes containing 2% to 5% of yellow phosphorus. Yellow phosphorous-containing rodenticides are easily available and account for one of the most common causes of suicidal poisoning in India. We describe a case of yellow phosphorus poisoning in a 17-years-old child who recovered from hepatic encephalopathy and showed unique peripheral smear findings in the form of spurious monocytosis and hypergranulosis of these granulocytes.

Journal of Cancer Research and Therapeutics

Pleomorphic xanthoastrocytoma (PXA) is a low-grade glioma comprising 1% of all astrocytomas with ... more Pleomorphic xanthoastrocytoma (PXA) is a low-grade glioma comprising 1% of all astrocytomas with an extremely rare anaplastic counterpart usually found in young adults. These tumors are most often cerebral in origin and their presentation in the elderly signifies poor prognosis. As these tumors are an important differential of glioblastoma, diagnosing them accurately is essential for management. We present a 68-year-male with positive cerebellar signs and clinico-radiological impression of cerebellar metastatic deposits, subsequently diagnosed as cerebellar PXA with anaplastic features. The case in discussion is unique in its age, site, and grade of presentation, with key histological features rebuking the clinical and radiological diagnosis of metastasis. The rarity and ambiguous management protocol of these tumors make their documentation an important addition to the existing literature with emphasis on possibility of late presentation and at sites other than the cerebrum.

IP Journal of Diagnostic Pathology and Oncology

Gaucher's disease is a rare, inherited autosomal recessive metabolic disorder due to deficien... more Gaucher's disease is a rare, inherited autosomal recessive metabolic disorder due to deficiency of enzyme Glucocerebrosidase resulting in deposition of glucosylceramide. Deposition of glucosylceramide in different organs causes dysfunction and is responsible for specific systemic symptoms and signs. In the present cases, the first case was a 24-year-old female who presented with severe weakness with abdominal fullness due to massive splenomegaly. The unicity of the case was anti-nuclear antibody positivity. Although clinical signs and symptoms were classical in this case. The second case was a 20-year-old male who was already diagnosed case of Gaucher's disease but the only complaint was abdominal fullness due to massive splenomegaly. Special stains were play a tremendous role to highlighting Gaucher's cells.

Tropical Doctor

Yellow phosphorus is one of the most commonly used rodenticides in India for household pest contr... more Yellow phosphorus is one of the most commonly used rodenticides in India for household pest control. It is available as pastes containing 2% to 5% of yellow phosphorus. Yellow phosphorous-containing rodenticides are easily available and account for one of the most common causes of suicidal poisoning in India. We describe a case of yellow phosphorus poisoning in a 17-years-old child who recovered from hepatic encephalopathy and showed unique peripheral smear findings in the form of spurious monocytosis and hypergranulosis of these granulocytes.

HbQ India is a rare α-chain structural hemoglobinopathy usually asymptomatic and presents in the ... more HbQ India is a rare α-chain structural hemoglobinopathy usually asymptomatic and presents in the heterozygous form or co-inherited with β-thalassemia trait. Herein, we are reporting the third case of novel association of HbQ India with HbS trait hemoglobinopathy in a 30-years-old young male presented with chief complaints of yellowish discoloration of sclera since 5-years with raised serum bilirubin levels along with pedigree analysis of the family.

Indian Journal of Pathology and Oncology

Lipoma is a well-known and most common soft tissue tumor. But multiple lipomatosis are rare. Also... more Lipoma is a well-known and most common soft tissue tumor. But multiple lipomatosis are rare. Also, syndromic associations were documented. Familial multiple lipomatosis (FML) is an autosomal dominant disorder. It presents as multiple lipomas in the body at specific sites. In presenting case 26-year-old patient complained of multiple swellings in his forearms, both thigh, and anterior abdominal wall for 5 years. A diagnosis of multiple lipomatosis is made by Fine needle aspiration cytology and confirmed by histopathological examination.