dipti magan | AIIMS - Academia.edu (original) (raw)
Papers by dipti magan
Indian journal of physiology and pharmacology, Dec 28, 2023
The Journal of Alternative and Complementary Medicine, 2013
Objective: To investigate the effect of a short-term yoga-based lifestyle intervention on risk fa... more Objective: To investigate the effect of a short-term yoga-based lifestyle intervention on risk factors for cardiovascular disease (CVD) and markers of inflammation and endothelial function in overweight and obese men. Design: Nonrandomized prospective lifestyle intervention study with pre-post design. Setting and location: Integral Health Clinic, an outpatient facility providing yoga-based lifestyle intervention programs for prevention and management of chronic diseases. Subjects: Overweight and obese men (n = 51) were enrolled in the study. Subjects who were physically unable to participate and those participating in other interventions were excluded from the study. Intervention: A pretested intervention program including asanas (physical postures), pranayama (breathing exercises), group discussions, lectures, and individualized advice. Outcome measures: The primary outcome measure was weight loss, and the secondary outcome measures were clinical and laboratory correlates of CVD risk, levels of interleukin-6 (IL-6), adiponectin, and endothelin-1 (ET-1). Results: Men (n = 51, body mass index [BMI] 26.26-2.42 kg/m 2) were enrolled and underwent a yoga-based lifestyle intervention for 10 days. Of 51 subjects, 30 completed the study. There was a significant reduction in
Acta Cardiologica, Oct 1, 2014
The objective of the study was to assess the effect of a brief but comprehensive yoga-based lifes... more The objective of the study was to assess the effect of a brief but comprehensive yoga-based lifestyle intervention on high-density lipoprotein cholesterol (HDL-c). This prospective interventional study was performed at the Integral Health Clinic (IHC), an outpatient facility at All India Institute of Medical Sciences, New Delhi, a tertiary health care centre, conducting yoga-based lifestyle intervention programmes for prevention and management of chronic diseases. The study included apparently healthy normal weight, overweight and obese subjects who underwent a pretested 10-day yoga-based programme including asanas (postures), pranayama (breathing exercises), meditation, group discussions, lectures and individualized advice on stress management and healthy diet. The primary outcome measure was change in serum HDL-c at day 10 versus day 0. 238 participants (147 women, 91 men, 38.81±11.40 years) were included in the study. There was a significant increase in HDL-c levels from baseline to day 10 (42.93±5.00 vs 43.52±5.07 mg/dL, P = 0.043). Notably, HDL-c was significantly improved in those for whom the baseline HDL-c levels were lower than the recommended values. Also, there was a reduction in blood pressure, fasting blood glucose, and improvement in other lipid profile variables. This yoga-based lifestyle intervention significantly increased HDL-c levels in a short duration of 10 days. This has additional clinical relevance as HDL-c is suggested to be one of the strongest statistically independent predictors of major cardiovascular events.
Journal of alternative and complementary medicine (New York, N.Y.), Jan 31, 2015
Chronic Fatigue Syndrome (CFS) is characterized by excessive fatigue after minimal physical or me... more Chronic Fatigue Syndrome (CFS) is characterized by excessive fatigue after minimal physical or mental exertion, muscle and joint pain, poor concentration, dizziness, and sleep disturbances. We report here the effect of a yoga-based lifestyle intervention in a 30-year old male patient with a documented diagnosis of CFS with compromised quality of life (QoL) and altered personality. The patient initially attended a short-term yoga-based lifestyle intervention program that consisted of yoga-postures, breathing exercises (pranayama), meditation, group discussions, and individualized advice on stress management, diet and physical activity besides group support. Thereafter, patient attended 5 more such programs. There was a notable and consistent improvement in his clinical profile, positive aspects of personality and subjective well-being, and reduction in anxiety following this yoga-based lifestyle intervention. Overall, the results suggest that lifestyle intervention may improve clinic...
Annals of Neurosciences
Background: Meditation is a conscious mental discipline, that has been implicated in the relaxati... more Background: Meditation is a conscious mental discipline, that has been implicated in the relaxation response. The mechanism behind such a relaxing effect is psychoneuroimmunology (PNI), based on the interaction between mind, physical health, and self-healing; that conceptualizes that stress and an individual’s emotional state led to predisposition to diseases. Research to date suggests that meditation may play an active role in remodeling the imbalance between mind and body by modulating the psychoneuroimmunological effects of stress. However, to date, the multi-dimensional psychoneuroimmune aspects of meditation together have not been completely explicated. An evidence-based mechanism has been framed for the first time in India to explain the psychoneuroimmunology of regular and long-term meditation practice. Summary: Present evidence-based mechanism confirms prefrontal cortex (PFC) acts as a ‘Functional Connectome’ where psycho-neuro-immune aspects of meditation function simultane...
International Journal of Clinical and Experimental Physiology, 2017
Background and Aim: The present report was designed to evaluate the efficacy of a short-term yoga... more Background and Aim: The present report was designed to evaluate the efficacy of a short-term yoga-based lifestyle intervention in modifying cognitive functions and brain activity during cognitive tasks in overweight/obese patients. Methods: A total of (n = 12) Overweight/Obese patients and (n = 9) healthy controls who attended a short-term yoga-based lifestyle intervention program were recruited for the study. Anthropometric parameters include height, weight, body mass index (BMI), and systolic and diastolic blood pressure; different cognitive domains include Controlled Oral Word Association Test,Symbol Digit Modalities Test, Verbal n-back Test, and Forward/backward digit span; self-report measures include the Freiburg Mindfulness Inventory and Centre for epidemiologic studies for depression scale and electroencephalography (EEG) activity during different cognitive tasks were carried out twice, i.e. day 1 (baseline) and day 14 (end of intervention). Results: Significant (P < 0.05...
Research in medical education aims to provide a platform for our understanding of learning, teach... more Research in medical education aims to provide a platform for our understanding of learning, teaching, and assessments in medicine. This can be achieved through improving research skills and quality of training in medical education and fosters the continued development of researchers and also to medical faculties, which can be extended to medical students. Keywords: MEDICAL RESEARCH, SKILLS, TRAINING, MEDICAL EDUCATORS, FACULTY DEVELOPMENT
Medical hypotheses, 2021
Broca's area, conventionally located in left (categorical) hemisphere of brain, is responsibl... more Broca's area, conventionally located in left (categorical) hemisphere of brain, is responsible for integrating linguistic and non-linguistic processing however, functionality of its right homolog remains partly understood and explored. This perception is based on the fact that in 96% of right-handed individuals, who constitute 91% of human population, the left hemisphere is dominant or categorical hemisphere. Here, we introduce novel scientific-based hypothesis that the right homolog of Broca's region which we observed hyperactive during attention focused meditation, might further play an important role in patients with attention deficits and language and speech disorders. Meditation includes self-regulation practices that focus on attention and awareness to achieve better control on mental processes. The positron emission tomography of brain in twelve (12) apparently healthy male, right-handed long-term meditators showed that the right Broca's area was significantly hyp...
Meditation is becoming increasingly popular as a topic for scientific research and are being incr... more Meditation is becoming increasingly popular as a topic for scientific research and are being increasingly used for stress, psychological well being, coping with chronic illness as well as adjunctive treatments for psychiatric disorders. Research suggests that these meditations have differential, dissociable effects on a wide range of cognitive (control) processes, such as attentional selection, conflict monitoring, divergent, and convergent thinking. Although research on exactly how the various meditations operate on these processes is still lacking, different kinds of meditations are associated with different neural structures and different patterns of electroencephalographic activity. The present communication suggest how the different meditations may affect cognitive processes and provide directions of future research.
Medical Hypotheses, 2020
Meditation is a complex mental process-practiced widely for stress management and promotion of he... more Meditation is a complex mental process-practiced widely for stress management and promotion of health- exerts beneficial effects on physical and mental health, and cognitive performance. However, until now, few theoretical neural mechanisms of meditation had been proposed, still not completely elucidated. We have previously evaluated the brain activity during Preksha meditation using an innovative 18FDG-PET methodological approach. Based on our previous study observations, we proposed here the neurophysiological framework of long-term and regular practice of preksha meditation. This mechanism will provide the scientific evidence to understand the attention control mechanisms resulting from the advanced state of preksha meditation. This might have multiple clinical applications as well as effective in a healthy population for attention-related tasks. Also, it is expected that the present neural model will provide a scientific platform for future clinical studies of meditation.
International Journal of Clinical and Experimental Physiology, 2019
Background and Aim: The present study was designed to evaluate the brain electrical activity amon... more Background and Aim: The present study was designed to evaluate the brain electrical activity among Long-term meditators (LTMs) and Short-term meditators (STMs) using Electroencephalography (EEG). Methods: This prospective study involved 40 mins of EEG recordings, carried out twice i.e. at Day 0 (Baseline) and at Day 10 (During meditation) in thirty-four (34) participants. Twelve (12) apparently healthy male, right-handed, practicing preksha meditation (Since >5 years, at least 5 days a week) were recruited as long-term meditators; Twelve (12) subjects who attended the 10-days short-term yoga-based lifestyle intervention program were recruited as short-term meditators; Ten (10) male healthy controls, who did not participate in any dietary/yoga intervention were recruited among the staff members. The EEG waves were analyzed at Day 0 and at Day 10 using Wilcoxon Signed Rank test and Repeated measured ANOVA respectively. One-way ANOVA was used for the baseline EEG waves activity comparison among LTMs vs. STMs vs. Controls. The response to photic stimulation was also assessed during meditation. Results: Significant different patterns of alpha and theta waves (p<0.05) activity was observed for LTM vs. STM during meditation vs. baseline. Also, significant different baseline EEG waves (p<0.05) were observed among LTM vs. STM vs. Controls. Conclusion: Findings may be useful in defining the basic EEG features to differentiate meditators based on the duration of practice of meditation and depth of meditation.
Journal of Complementary and Integrative Medicine, 2019
Background Nowadays, yoga is endorsed and advised routinely to stay fit and healthy, as well as c... more Background Nowadays, yoga is endorsed and advised routinely to stay fit and healthy, as well as control many chronic diseases including diabetes type 2, hypertension, coronary artery diseases, etc. Now, our assumption is that those who do regular yoga have different persona than who do not do yoga regularly. We planned to test our hypothesis scientifically, and therefore baseline physiological characteristics with stress and inflammation levels in long-term and short-term meditators and healthy novice controls were analyzed. Methods In this retrospective analysis, 97 male participants were included for their Baseline analysis. Fifteen apparently healthy subjects practicing preksha meditation (since >5 years, at least 5 days a week) were included as long-term meditators (LTMs); 58 subjects who attended one of our short-term yoga-based lifestyle intervention programs for 2 weeks were included as short-term meditators (STMs); 24 male novice subjects, who did not participate in any y...
Indian journal of physiology and pharmacology
Age and gender are two important physiological variables which might influence the personality of... more Age and gender are two important physiological variables which might influence the personality of an individual. The influence of age and gender on big five personality domains in Indian population was assessed in this cross-sectional study that included 155 subjects (female=76, male=79) aged from 16-75 years. Big five personality factors were evaluated using 60-item NEO-Five Factor Inventory (NEO-FFI) at a single point in time. Among the big five factors of personality, Conscientiousness was positively correlated (r=0.195;
The Journal of Alternative and Complementary Medicine, 2012
Indian journal of physiology and pharmacology
Age and gender are two important physiological variables which might influence the personality of... more Age and gender are two important physiological variables which might influence the personality of an individual. The influence of age and gender on big five personality domains in Indian population was assessed in this cross-sectional study that included 155 subjects (female = 76, male = 79) aged from 16-75 years. Big five personality factors were evaluated using 60-item NEO-Five Factor Inventory (NEO-FFI) at a single point in time. Among the big five factors of personality, Conscientiousness was positively correlated (r = 0.195; P < 0.05) with age in total study population, and retained the significance (P < 0.05) in men only when analyzed by gender subgroups. Further, age and gender sub-group analysis also showed that Neuroticism was inversely correlated with age in women aged 26-35 years (P < 0.05). Neuroticism and Extraversion showed a positive correlation with age in men aged 36-45 years (P < 0.001 and P < 0.05, respectively). Neuroticism was inversely correlated...
Indian journal of physiology and pharmacology, Dec 28, 2023
The Journal of Alternative and Complementary Medicine, 2013
Objective: To investigate the effect of a short-term yoga-based lifestyle intervention on risk fa... more Objective: To investigate the effect of a short-term yoga-based lifestyle intervention on risk factors for cardiovascular disease (CVD) and markers of inflammation and endothelial function in overweight and obese men. Design: Nonrandomized prospective lifestyle intervention study with pre-post design. Setting and location: Integral Health Clinic, an outpatient facility providing yoga-based lifestyle intervention programs for prevention and management of chronic diseases. Subjects: Overweight and obese men (n = 51) were enrolled in the study. Subjects who were physically unable to participate and those participating in other interventions were excluded from the study. Intervention: A pretested intervention program including asanas (physical postures), pranayama (breathing exercises), group discussions, lectures, and individualized advice. Outcome measures: The primary outcome measure was weight loss, and the secondary outcome measures were clinical and laboratory correlates of CVD risk, levels of interleukin-6 (IL-6), adiponectin, and endothelin-1 (ET-1). Results: Men (n = 51, body mass index [BMI] 26.26-2.42 kg/m 2) were enrolled and underwent a yoga-based lifestyle intervention for 10 days. Of 51 subjects, 30 completed the study. There was a significant reduction in
Acta Cardiologica, Oct 1, 2014
The objective of the study was to assess the effect of a brief but comprehensive yoga-based lifes... more The objective of the study was to assess the effect of a brief but comprehensive yoga-based lifestyle intervention on high-density lipoprotein cholesterol (HDL-c). This prospective interventional study was performed at the Integral Health Clinic (IHC), an outpatient facility at All India Institute of Medical Sciences, New Delhi, a tertiary health care centre, conducting yoga-based lifestyle intervention programmes for prevention and management of chronic diseases. The study included apparently healthy normal weight, overweight and obese subjects who underwent a pretested 10-day yoga-based programme including asanas (postures), pranayama (breathing exercises), meditation, group discussions, lectures and individualized advice on stress management and healthy diet. The primary outcome measure was change in serum HDL-c at day 10 versus day 0. 238 participants (147 women, 91 men, 38.81±11.40 years) were included in the study. There was a significant increase in HDL-c levels from baseline to day 10 (42.93±5.00 vs 43.52±5.07 mg/dL, P = 0.043). Notably, HDL-c was significantly improved in those for whom the baseline HDL-c levels were lower than the recommended values. Also, there was a reduction in blood pressure, fasting blood glucose, and improvement in other lipid profile variables. This yoga-based lifestyle intervention significantly increased HDL-c levels in a short duration of 10 days. This has additional clinical relevance as HDL-c is suggested to be one of the strongest statistically independent predictors of major cardiovascular events.
Journal of alternative and complementary medicine (New York, N.Y.), Jan 31, 2015
Chronic Fatigue Syndrome (CFS) is characterized by excessive fatigue after minimal physical or me... more Chronic Fatigue Syndrome (CFS) is characterized by excessive fatigue after minimal physical or mental exertion, muscle and joint pain, poor concentration, dizziness, and sleep disturbances. We report here the effect of a yoga-based lifestyle intervention in a 30-year old male patient with a documented diagnosis of CFS with compromised quality of life (QoL) and altered personality. The patient initially attended a short-term yoga-based lifestyle intervention program that consisted of yoga-postures, breathing exercises (pranayama), meditation, group discussions, and individualized advice on stress management, diet and physical activity besides group support. Thereafter, patient attended 5 more such programs. There was a notable and consistent improvement in his clinical profile, positive aspects of personality and subjective well-being, and reduction in anxiety following this yoga-based lifestyle intervention. Overall, the results suggest that lifestyle intervention may improve clinic...
Annals of Neurosciences
Background: Meditation is a conscious mental discipline, that has been implicated in the relaxati... more Background: Meditation is a conscious mental discipline, that has been implicated in the relaxation response. The mechanism behind such a relaxing effect is psychoneuroimmunology (PNI), based on the interaction between mind, physical health, and self-healing; that conceptualizes that stress and an individual’s emotional state led to predisposition to diseases. Research to date suggests that meditation may play an active role in remodeling the imbalance between mind and body by modulating the psychoneuroimmunological effects of stress. However, to date, the multi-dimensional psychoneuroimmune aspects of meditation together have not been completely explicated. An evidence-based mechanism has been framed for the first time in India to explain the psychoneuroimmunology of regular and long-term meditation practice. Summary: Present evidence-based mechanism confirms prefrontal cortex (PFC) acts as a ‘Functional Connectome’ where psycho-neuro-immune aspects of meditation function simultane...
International Journal of Clinical and Experimental Physiology, 2017
Background and Aim: The present report was designed to evaluate the efficacy of a short-term yoga... more Background and Aim: The present report was designed to evaluate the efficacy of a short-term yoga-based lifestyle intervention in modifying cognitive functions and brain activity during cognitive tasks in overweight/obese patients. Methods: A total of (n = 12) Overweight/Obese patients and (n = 9) healthy controls who attended a short-term yoga-based lifestyle intervention program were recruited for the study. Anthropometric parameters include height, weight, body mass index (BMI), and systolic and diastolic blood pressure; different cognitive domains include Controlled Oral Word Association Test,Symbol Digit Modalities Test, Verbal n-back Test, and Forward/backward digit span; self-report measures include the Freiburg Mindfulness Inventory and Centre for epidemiologic studies for depression scale and electroencephalography (EEG) activity during different cognitive tasks were carried out twice, i.e. day 1 (baseline) and day 14 (end of intervention). Results: Significant (P < 0.05...
Research in medical education aims to provide a platform for our understanding of learning, teach... more Research in medical education aims to provide a platform for our understanding of learning, teaching, and assessments in medicine. This can be achieved through improving research skills and quality of training in medical education and fosters the continued development of researchers and also to medical faculties, which can be extended to medical students. Keywords: MEDICAL RESEARCH, SKILLS, TRAINING, MEDICAL EDUCATORS, FACULTY DEVELOPMENT
Medical hypotheses, 2021
Broca's area, conventionally located in left (categorical) hemisphere of brain, is responsibl... more Broca's area, conventionally located in left (categorical) hemisphere of brain, is responsible for integrating linguistic and non-linguistic processing however, functionality of its right homolog remains partly understood and explored. This perception is based on the fact that in 96% of right-handed individuals, who constitute 91% of human population, the left hemisphere is dominant or categorical hemisphere. Here, we introduce novel scientific-based hypothesis that the right homolog of Broca's region which we observed hyperactive during attention focused meditation, might further play an important role in patients with attention deficits and language and speech disorders. Meditation includes self-regulation practices that focus on attention and awareness to achieve better control on mental processes. The positron emission tomography of brain in twelve (12) apparently healthy male, right-handed long-term meditators showed that the right Broca's area was significantly hyp...
Meditation is becoming increasingly popular as a topic for scientific research and are being incr... more Meditation is becoming increasingly popular as a topic for scientific research and are being increasingly used for stress, psychological well being, coping with chronic illness as well as adjunctive treatments for psychiatric disorders. Research suggests that these meditations have differential, dissociable effects on a wide range of cognitive (control) processes, such as attentional selection, conflict monitoring, divergent, and convergent thinking. Although research on exactly how the various meditations operate on these processes is still lacking, different kinds of meditations are associated with different neural structures and different patterns of electroencephalographic activity. The present communication suggest how the different meditations may affect cognitive processes and provide directions of future research.
Medical Hypotheses, 2020
Meditation is a complex mental process-practiced widely for stress management and promotion of he... more Meditation is a complex mental process-practiced widely for stress management and promotion of health- exerts beneficial effects on physical and mental health, and cognitive performance. However, until now, few theoretical neural mechanisms of meditation had been proposed, still not completely elucidated. We have previously evaluated the brain activity during Preksha meditation using an innovative 18FDG-PET methodological approach. Based on our previous study observations, we proposed here the neurophysiological framework of long-term and regular practice of preksha meditation. This mechanism will provide the scientific evidence to understand the attention control mechanisms resulting from the advanced state of preksha meditation. This might have multiple clinical applications as well as effective in a healthy population for attention-related tasks. Also, it is expected that the present neural model will provide a scientific platform for future clinical studies of meditation.
International Journal of Clinical and Experimental Physiology, 2019
Background and Aim: The present study was designed to evaluate the brain electrical activity amon... more Background and Aim: The present study was designed to evaluate the brain electrical activity among Long-term meditators (LTMs) and Short-term meditators (STMs) using Electroencephalography (EEG). Methods: This prospective study involved 40 mins of EEG recordings, carried out twice i.e. at Day 0 (Baseline) and at Day 10 (During meditation) in thirty-four (34) participants. Twelve (12) apparently healthy male, right-handed, practicing preksha meditation (Since >5 years, at least 5 days a week) were recruited as long-term meditators; Twelve (12) subjects who attended the 10-days short-term yoga-based lifestyle intervention program were recruited as short-term meditators; Ten (10) male healthy controls, who did not participate in any dietary/yoga intervention were recruited among the staff members. The EEG waves were analyzed at Day 0 and at Day 10 using Wilcoxon Signed Rank test and Repeated measured ANOVA respectively. One-way ANOVA was used for the baseline EEG waves activity comparison among LTMs vs. STMs vs. Controls. The response to photic stimulation was also assessed during meditation. Results: Significant different patterns of alpha and theta waves (p<0.05) activity was observed for LTM vs. STM during meditation vs. baseline. Also, significant different baseline EEG waves (p<0.05) were observed among LTM vs. STM vs. Controls. Conclusion: Findings may be useful in defining the basic EEG features to differentiate meditators based on the duration of practice of meditation and depth of meditation.
Journal of Complementary and Integrative Medicine, 2019
Background Nowadays, yoga is endorsed and advised routinely to stay fit and healthy, as well as c... more Background Nowadays, yoga is endorsed and advised routinely to stay fit and healthy, as well as control many chronic diseases including diabetes type 2, hypertension, coronary artery diseases, etc. Now, our assumption is that those who do regular yoga have different persona than who do not do yoga regularly. We planned to test our hypothesis scientifically, and therefore baseline physiological characteristics with stress and inflammation levels in long-term and short-term meditators and healthy novice controls were analyzed. Methods In this retrospective analysis, 97 male participants were included for their Baseline analysis. Fifteen apparently healthy subjects practicing preksha meditation (since >5 years, at least 5 days a week) were included as long-term meditators (LTMs); 58 subjects who attended one of our short-term yoga-based lifestyle intervention programs for 2 weeks were included as short-term meditators (STMs); 24 male novice subjects, who did not participate in any y...
Indian journal of physiology and pharmacology
Age and gender are two important physiological variables which might influence the personality of... more Age and gender are two important physiological variables which might influence the personality of an individual. The influence of age and gender on big five personality domains in Indian population was assessed in this cross-sectional study that included 155 subjects (female=76, male=79) aged from 16-75 years. Big five personality factors were evaluated using 60-item NEO-Five Factor Inventory (NEO-FFI) at a single point in time. Among the big five factors of personality, Conscientiousness was positively correlated (r=0.195;
The Journal of Alternative and Complementary Medicine, 2012
Indian journal of physiology and pharmacology
Age and gender are two important physiological variables which might influence the personality of... more Age and gender are two important physiological variables which might influence the personality of an individual. The influence of age and gender on big five personality domains in Indian population was assessed in this cross-sectional study that included 155 subjects (female = 76, male = 79) aged from 16-75 years. Big five personality factors were evaluated using 60-item NEO-Five Factor Inventory (NEO-FFI) at a single point in time. Among the big five factors of personality, Conscientiousness was positively correlated (r = 0.195; P < 0.05) with age in total study population, and retained the significance (P < 0.05) in men only when analyzed by gender subgroups. Further, age and gender sub-group analysis also showed that Neuroticism was inversely correlated with age in women aged 26-35 years (P < 0.05). Neuroticism and Extraversion showed a positive correlation with age in men aged 36-45 years (P < 0.001 and P < 0.05, respectively). Neuroticism was inversely correlated...