Mizanur Rahman | American International University-Bangladesh (original) (raw)

Papers by Mizanur Rahman

The purpose of this study was to assess the duration of breastfeeding and the sociodemographic fa... more The purpose of this study was to assess the duration of breastfeeding and the sociodemographic factors affecting it. Data for the study were drawn from the Bangladesh Demographic and Health Survey 2004. In total 5,364 mothers were included in the study. The life table and Cox's proportional hazards model were employed for the analysis of breastfeeding-related data, which showed that the average duration of breastfeeding was 31.9 months. Cox regression analysis revealed that the duration of breastfeeding was positively associated with maternal age, contraceptive-use, work status, and religion and was negatively associated with age at marriage, parity, delivery status, region, and maternal education. Younger mothers, having higher education, higher maternal parity, caesarean-section birth, being a Muslim, and mothers who have not used any contraceptive were associated with lower duration of breastfeeding. The findings suggest that health institutions can play a significant role in promoting breastfeeding in Bangladesh. Educational campaigns that stress the benefits of lactation are important strategies for encouraging mothers to breastfeed longer.

Surgical Endoscopy, Feb 1, 2000

The extrahepatic biliary tree with the exact anatomic features of the arterial supply observed by... more The extrahepatic biliary tree with the exact anatomic features of the arterial supply observed by laparoscopic means has not been described heretofore. Iatrogenic injuries of the extrahepatic biliary tree and neighboring blood vessels are not rare. Accidents involving vessels or the common bile duct during laparoscopic cholecystectomy, with or without choledocotomy, can be avoided by careful dissection of Calot's triangle and the hepatoduodenal ligament. We performed 244 laparoscopic cholecystectomies over a 2-year period between January 1, 1995 and January 1, 1997. In 187 of 244 consecutive cases (76.6%), we found a typical arterial supply anteromedial to the cystic duct, near the sentinel cystic lymph node. In the other cases, there was an atypical arterial supply, and 27 of these cases (11.1%) had no cystic artery in Calot's triangle. A typical blood supply and accessory arteries were observed in 18 cases (7.4%). Young surgeons who are not yet familiar with the handling of an anatomically abnormal cystic blood supply need to be more aware of the precise anatomy of the extrahepatic biliary tree.

Nuovo Cimento a Nucl Part F, 1992

Summary Austern and Blair have established the connection between inelastic and elastic nuclear s... more Summary Austern and Blair have established the connection between inelastic and elastic nuclear scattering of strongly absorbed particles in the adiabatic approximation. Simple closed expressions again in the adiabatic approximation, under strong absorption ...

Vertical fragmentation of product value chain across borders is the driving force of growing econ... more Vertical fragmentation of product value chain across borders is the driving force of growing economic interdependency in East Asia. A common currency, not flexible exchange rates between national currencies, would reduce flexibility in relative prices within East Asia. Its impact would be far greater for exports that have stronger production network linkage. In order to test the hypothesis, the paper estimates the effect of a common currency on China's processing and ordinary exports separately. The distinction is necessary because the processing exports, unlike the ordinary exports, are produced along the regional production networks, with final stages of assembly and exporting being increasingly concentrated in China. The short-run dynamics indicate that the effect on China's processing exports is more than double the corresponding effect on China's ordinary exports. The long-run effect on the processing exports of intra-regional RER flexibility, which is otherwise the lack of a regional currency, is almost nine times as large as the long-run effect of a unilateral RMB appreciation. By contrast, the corresponding long-run effect is statistically insignificant for the case of ordinary exports that are produced primarily by using local inputs. The long-run coefficient of this intraregional RER flexibility implies that the actual volume of processing exports is 20 percent below the potential. The magnitudes of these effects are consistent with the hypothesis that a common currency would further integrate East Asian production networks and promote regional economic integration.

The Faseb Journal, Apr 1, 2010

The lack of electricity is widespread in the rural areas of the developing countries. Extensive p... more The lack of electricity is widespread in the rural areas of the developing countries. Extensive production of agricultural crops and livestock in the rural areas simultaneously provides abundant amounts of residues every year. The residues usually lay in scattered places and they have diverse characteristics and a major part is somewhat wasted and unused. To explore the ways to use these residues in an innovative and sustainable manner, it is essential to be acquainted with the amounts that are actually available beyond their current other applications. This paper proposes a mathematical method to quantify the residues with characteristics fractions and data processing techniques. The significance of this method is that it shows the residue potential through anaerobic digestion (AD) process and correlates directly with annual crops and animal production. This paper also proposes a methodology to gather these resources to check their viability. The authors find that the available agricultural residues in the rural areas of Bangladesh, India, Nepal, Pakistan, and Sri Lanka have annual electricity production potential through anaerobic digestion (AD) are 679kWh e ,820kWh e , 724kWh e , 1238kWh e and 479kWh e per rural households(HHS) respectively, which are reasonably sufficient to meet the basic demand 365kWh e .

Acs Chem Biol 10 766 774, Mar 20, 2015

The progressive neurodegeneration in Alzheimer's disease is believed to be linked to the presence... more The progressive neurodegeneration in Alzheimer's disease is believed to be linked to the presence of prefibrillar aggregates of the amyloid-β (Aβ) peptide in the brain. The exact role of these aggregates in the disease pathology is, however, still an open question. Any mechanism by which oligomeric Aβ may cause damage to neuronal cells must, in one way or another, involve interactions with other molecules. Here, we identify proteins in human serum and cerebrospinal fluid that bind to stable protofibrils formed by an engineered variant of Aβ 42 (Aβ 42CC ). We find that the protofibrils attract a substantial number of protein binding partners. Many of the 101 identified proteins are involved in lipid transport and metabolism, the complement system, or in hemostasis. Binding of representative proteins from all of these groups with micromolar affinity was confirmed using surface plasmon resonance. In addition, binding of apolipoprotein E to the protofibrils with nanomolar affinity was demonstrated. We also find that aggregation of Aβ enhances protein binding, as lower amounts of proteins bind monomeric Aβ. Proteins that bind to Aβ protofibrils might contribute to biological effects in which these aggregates are involved. Our results therefore suggest that an improved understanding of the mechanisms by which Aβ causes cytotoxicity and neurodegeneration might be gained from studies carried out in biologically relevant matrices in which Aβ-binding proteins are present.

Applied Economics, Jul 31, 2008

In this paper we examine sources of technical efficiency for rice farming in Bangladesh. The moti... more In this paper we examine sources of technical efficiency for rice farming in Bangladesh. The motivation for the analysis is the need to close the rice yield gap to enable food security. We employ the DEA double bootstrap of to estimate and explain technical efficiency. This technique overcomes severe limitations inherent in using the two-stage DEA approach commonly employed in the efficiency literature. From a policy perspective our results show that potential efficiency gains to reduce the yield gap are greater than previously found. Statistically positive influences on technical efficiency are education, extension and credit, with age being a negative influence.

Surface Coatings Technology, 2007

We conducted an electroplating reaction in a constantly agitated ternary system of dense carbon d... more We conducted an electroplating reaction in a constantly agitated ternary system of dense carbon dioxide (CO 2 ) and electroplating solution with a novel fluorinated surfactant, F(CF(CF 3 )CF 2 O) 3 CF(CF 3 )COO(CH 2 CH 2 O)CH 3 . The reaction in the emulsion was investigated as a function of the CO 2 volume fraction and surfactant concentration. With a low surfactant concentration, the nickel film plated in an emulsion composed of less than 20% CO 2 by volume was flat with many pinholes. Electroplating with a 0.09% surfactant concentration in the plating solution by volume formed a smooth film surface free of pinholes. The novel porous film of nickel was fabricated with a 0.12% concentration in the emulsion by volume. Electroplating was found to be possible in an emulsion composed of 40% CO 2 and 60% electroplating solution by volume. Smooth plated films free of pinholes were obtained from the emulsion system in the composition range of 20-40% CO 2 by volume with the novel fluorinated surfactant. With an increase of the surfactant concentration, nickel films with a multi-porous structure were obtained in an emulsion composed of less than 20% CO 2 by volume. This metallic film had a complicated porous structure made up of spheroidal pores of various diameters. We suggested that this novel porous structure could have originated from the emulsion of the electroplating solution and dense CO 2 with the novel fluorinated surfactant. The structure could have been fabricated via the formation of "hard" micelles in the reaction system with a specific surfactant concentration and CO 2 composition. CO 2 in a water micro-emulsion was formed in this reaction system and the dispersion states influenced the novel multiporous structure of the plated film.

Aiaa Journal, May 17, 2012

Http Dx Doi Org 10 1080 17441730902992059, Jul 27, 2009

This study explores and suggests a methodological approach to the gender dimensions of remittance... more This study explores and suggests a methodological approach to the gender dimensions of remittances. It argues that remittances should be seen as a social process and examined in relation to (i) the sending side, (ii) the recipient side and (iii) gendered use of remittances by the ...

Frontiers in Bioscience a Journal and Virtual Library, Jan 5, 2008

Decreased consumption of n-3 fatty acids (FA) and diets rich in animal proteins, saturated fats a... more Decreased consumption of n-3 fatty acids (FA) and diets rich in animal proteins, saturated fats and n-6 vegetable oils are associated with a higher incidence of cardiovascular disease (CVD), certain malignancies and autoimmune disorders such as rheumatoid arthritis and Systemic Lupus Erythematosus (SLE), and renal disease. Recent studies show that reduced calorie intake and supplementation of diet with n-3 FA delays the onset of autoimmune renal disease, primarily, due to increased antioxidant enzyme activities, decreased NF-kappaB activation and decreased IL-1, IL-6 and TNF-alpha mRNA expression in the kidney tissue. Studies in rodents show that addition of n-3 FA and soy protein to diet affords protection against bone loss induced by ovariectomy in mice due to NF-kappaB expression and decreased activation of osteoclasts. Together, the available evidence show that increased daily intake of dietary n-3 FA decreases the severity of autoimmune disorders, lessens the chance of developing CVD, and protects against bone loss during post-menopause.

International Perspectives on Sexual and Reproductive Health, Dec 1, 2010

The Matlab Maternal Child Health-Family Planning (MCH-FP) project provides maternity care as part... more The Matlab Maternal Child Health-Family Planning (MCH-FP) project provides maternity care as part of its reproductive health services. It is important to assess whether this project has reduced maternal mortality and, if so, whether this was due to differences between the MCH-FP area (which received project services) and the comparison area (which did not) in pregnancy rates, pregnancy outcomes or case-fatality rates. Data from the Matlab Demographic Surveillance System on 165,894 pregnancies over the period 1982-2005 were used to calculate four measures of maternal mortality for the MCH-FP and comparison areas. Mortality risk was examined by type of pregnancy outcome and by area, and bivariate and logistic regression analyses were used to generate unadjusted and adjusted odds ratios, respectively. The maternal mortality rate of 35 deaths per 100,000 women of reproductive age in the MCH-FP area was 37% lower than that in the comparison area (56 deaths per 100,000). In both areas, the maternal mortality risk was considerably higher for pregnancies that ended in induced abortion, miscarriage or stillbirth than for those that resulted in live birth (odds ratios, 4.2, 2.0 and 17.4, respectively). The difference in maternal mortality rates between the two areas was mainly a result of the MCH-FP area's lower pregnancy rate and its lower case-fatality rates for induced abortions, miscarriages and stillbirths. Interventions to increase contraceptive use; to reduce the incidence of induced abortion, miscarriage and stillbirth; to improve the management of such outcomes; and to strengthen antenatal care could substantially reduce maternal mortality in Bangladesh and similar countries.

Http Dx Doi Org 10 1080 1369183x 2012 659129, Mar 12, 2012

... Huffman SL, Chowdhury A, Allen H, Nahar L (1987). Suckling patterns and post-partum amenorrhe... more ... Huffman SL, Chowdhury A, Allen H, Nahar L (1987). Suckling patterns and post-partum amenorrhea in Bangladesh. J. Biosoc. Sci. 19: 171-179. ... National Institute of Population Research and Training (NIPORT), Dhaka, Bangladesh. Nessa F, Rahman S, Ahmed AKMS (1987). ...

Journal of Bone and Mineral Metabolism, Apr 15, 2010

Aging is associated with bone loss, leading to increased risk of fractures. Recently, there is gr... more Aging is associated with bone loss, leading to increased risk of fractures. Recently, there is growing interest in identifying nutritional supplements that can prevent bone loss with minimum side effects. There is increasing evidence for the beneficial effects of n-3 fatty acids in the prevention of bone loss. A transgenic mouse model (fat-1) that produces n-3 fatty acids endogenously and its wild type counterpart were used in this study to determine the effects of endogenously produced n-3 fatty acids on serum bone turnover markers, long bones, and lumbar vertebrae. Serum alkaline phosphatase and P1NP levels decreased significantly in wild type mice after ovariectomy. No significant changes were seen in osteocalcin. Cancellous and cortical bone mass were higher in the femur of fat-1 mice. In wild type mice, there was significant loss of bone after ovariectomy in the distal femur, femoral neck, proximal tibia, and fourth lumbar vertebra. However, in fat-1 mice, there was no, or significantly less, bone lost after ovariectomy in all the sites studied. We conclude that endogenously produced n-3 fatty acids can attenuate ovariectomy induced bone loss in the different bone sites studied, mainly as a consequence of decreased bone resorption at the endosteal surface.

The purpose of this study was to assess the duration of breastfeeding and the sociodemographic fa... more The purpose of this study was to assess the duration of breastfeeding and the sociodemographic factors affecting it. Data for the study were drawn from the Bangladesh Demographic and Health Survey 2004. In total 5,364 mothers were included in the study. The life table and Cox's proportional hazards model were employed for the analysis of breastfeeding-related data, which showed that the average duration of breastfeeding was 31.9 months. Cox regression analysis revealed that the duration of breastfeeding was positively associated with maternal age, contraceptive-use, work status, and religion and was negatively associated with age at marriage, parity, delivery status, region, and maternal education. Younger mothers, having higher education, higher maternal parity, caesarean-section birth, being a Muslim, and mothers who have not used any contraceptive were associated with lower duration of breastfeeding. The findings suggest that health institutions can play a significant role in promoting breastfeeding in Bangladesh. Educational campaigns that stress the benefits of lactation are important strategies for encouraging mothers to breastfeed longer.

Surgical Endoscopy, Feb 1, 2000

The extrahepatic biliary tree with the exact anatomic features of the arterial supply observed by... more The extrahepatic biliary tree with the exact anatomic features of the arterial supply observed by laparoscopic means has not been described heretofore. Iatrogenic injuries of the extrahepatic biliary tree and neighboring blood vessels are not rare. Accidents involving vessels or the common bile duct during laparoscopic cholecystectomy, with or without choledocotomy, can be avoided by careful dissection of Calot's triangle and the hepatoduodenal ligament. We performed 244 laparoscopic cholecystectomies over a 2-year period between January 1, 1995 and January 1, 1997. In 187 of 244 consecutive cases (76.6%), we found a typical arterial supply anteromedial to the cystic duct, near the sentinel cystic lymph node. In the other cases, there was an atypical arterial supply, and 27 of these cases (11.1%) had no cystic artery in Calot's triangle. A typical blood supply and accessory arteries were observed in 18 cases (7.4%). Young surgeons who are not yet familiar with the handling of an anatomically abnormal cystic blood supply need to be more aware of the precise anatomy of the extrahepatic biliary tree.

Nuovo Cimento a Nucl Part F, 1992

Summary Austern and Blair have established the connection between inelastic and elastic nuclear s... more Summary Austern and Blair have established the connection between inelastic and elastic nuclear scattering of strongly absorbed particles in the adiabatic approximation. Simple closed expressions again in the adiabatic approximation, under strong absorption ...

Vertical fragmentation of product value chain across borders is the driving force of growing econ... more Vertical fragmentation of product value chain across borders is the driving force of growing economic interdependency in East Asia. A common currency, not flexible exchange rates between national currencies, would reduce flexibility in relative prices within East Asia. Its impact would be far greater for exports that have stronger production network linkage. In order to test the hypothesis, the paper estimates the effect of a common currency on China's processing and ordinary exports separately. The distinction is necessary because the processing exports, unlike the ordinary exports, are produced along the regional production networks, with final stages of assembly and exporting being increasingly concentrated in China. The short-run dynamics indicate that the effect on China's processing exports is more than double the corresponding effect on China's ordinary exports. The long-run effect on the processing exports of intra-regional RER flexibility, which is otherwise the lack of a regional currency, is almost nine times as large as the long-run effect of a unilateral RMB appreciation. By contrast, the corresponding long-run effect is statistically insignificant for the case of ordinary exports that are produced primarily by using local inputs. The long-run coefficient of this intraregional RER flexibility implies that the actual volume of processing exports is 20 percent below the potential. The magnitudes of these effects are consistent with the hypothesis that a common currency would further integrate East Asian production networks and promote regional economic integration.

The Faseb Journal, Apr 1, 2010

The lack of electricity is widespread in the rural areas of the developing countries. Extensive p... more The lack of electricity is widespread in the rural areas of the developing countries. Extensive production of agricultural crops and livestock in the rural areas simultaneously provides abundant amounts of residues every year. The residues usually lay in scattered places and they have diverse characteristics and a major part is somewhat wasted and unused. To explore the ways to use these residues in an innovative and sustainable manner, it is essential to be acquainted with the amounts that are actually available beyond their current other applications. This paper proposes a mathematical method to quantify the residues with characteristics fractions and data processing techniques. The significance of this method is that it shows the residue potential through anaerobic digestion (AD) process and correlates directly with annual crops and animal production. This paper also proposes a methodology to gather these resources to check their viability. The authors find that the available agricultural residues in the rural areas of Bangladesh, India, Nepal, Pakistan, and Sri Lanka have annual electricity production potential through anaerobic digestion (AD) are 679kWh e ,820kWh e , 724kWh e , 1238kWh e and 479kWh e per rural households(HHS) respectively, which are reasonably sufficient to meet the basic demand 365kWh e .

Acs Chem Biol 10 766 774, Mar 20, 2015

The progressive neurodegeneration in Alzheimer's disease is believed to be linked to the presence... more The progressive neurodegeneration in Alzheimer's disease is believed to be linked to the presence of prefibrillar aggregates of the amyloid-β (Aβ) peptide in the brain. The exact role of these aggregates in the disease pathology is, however, still an open question. Any mechanism by which oligomeric Aβ may cause damage to neuronal cells must, in one way or another, involve interactions with other molecules. Here, we identify proteins in human serum and cerebrospinal fluid that bind to stable protofibrils formed by an engineered variant of Aβ 42 (Aβ 42CC ). We find that the protofibrils attract a substantial number of protein binding partners. Many of the 101 identified proteins are involved in lipid transport and metabolism, the complement system, or in hemostasis. Binding of representative proteins from all of these groups with micromolar affinity was confirmed using surface plasmon resonance. In addition, binding of apolipoprotein E to the protofibrils with nanomolar affinity was demonstrated. We also find that aggregation of Aβ enhances protein binding, as lower amounts of proteins bind monomeric Aβ. Proteins that bind to Aβ protofibrils might contribute to biological effects in which these aggregates are involved. Our results therefore suggest that an improved understanding of the mechanisms by which Aβ causes cytotoxicity and neurodegeneration might be gained from studies carried out in biologically relevant matrices in which Aβ-binding proteins are present.

Applied Economics, Jul 31, 2008

In this paper we examine sources of technical efficiency for rice farming in Bangladesh. The moti... more In this paper we examine sources of technical efficiency for rice farming in Bangladesh. The motivation for the analysis is the need to close the rice yield gap to enable food security. We employ the DEA double bootstrap of to estimate and explain technical efficiency. This technique overcomes severe limitations inherent in using the two-stage DEA approach commonly employed in the efficiency literature. From a policy perspective our results show that potential efficiency gains to reduce the yield gap are greater than previously found. Statistically positive influences on technical efficiency are education, extension and credit, with age being a negative influence.

Surface Coatings Technology, 2007

We conducted an electroplating reaction in a constantly agitated ternary system of dense carbon d... more We conducted an electroplating reaction in a constantly agitated ternary system of dense carbon dioxide (CO 2 ) and electroplating solution with a novel fluorinated surfactant, F(CF(CF 3 )CF 2 O) 3 CF(CF 3 )COO(CH 2 CH 2 O)CH 3 . The reaction in the emulsion was investigated as a function of the CO 2 volume fraction and surfactant concentration. With a low surfactant concentration, the nickel film plated in an emulsion composed of less than 20% CO 2 by volume was flat with many pinholes. Electroplating with a 0.09% surfactant concentration in the plating solution by volume formed a smooth film surface free of pinholes. The novel porous film of nickel was fabricated with a 0.12% concentration in the emulsion by volume. Electroplating was found to be possible in an emulsion composed of 40% CO 2 and 60% electroplating solution by volume. Smooth plated films free of pinholes were obtained from the emulsion system in the composition range of 20-40% CO 2 by volume with the novel fluorinated surfactant. With an increase of the surfactant concentration, nickel films with a multi-porous structure were obtained in an emulsion composed of less than 20% CO 2 by volume. This metallic film had a complicated porous structure made up of spheroidal pores of various diameters. We suggested that this novel porous structure could have originated from the emulsion of the electroplating solution and dense CO 2 with the novel fluorinated surfactant. The structure could have been fabricated via the formation of "hard" micelles in the reaction system with a specific surfactant concentration and CO 2 composition. CO 2 in a water micro-emulsion was formed in this reaction system and the dispersion states influenced the novel multiporous structure of the plated film.

Aiaa Journal, May 17, 2012

Http Dx Doi Org 10 1080 17441730902992059, Jul 27, 2009

This study explores and suggests a methodological approach to the gender dimensions of remittance... more This study explores and suggests a methodological approach to the gender dimensions of remittances. It argues that remittances should be seen as a social process and examined in relation to (i) the sending side, (ii) the recipient side and (iii) gendered use of remittances by the ...

Frontiers in Bioscience a Journal and Virtual Library, Jan 5, 2008

Decreased consumption of n-3 fatty acids (FA) and diets rich in animal proteins, saturated fats a... more Decreased consumption of n-3 fatty acids (FA) and diets rich in animal proteins, saturated fats and n-6 vegetable oils are associated with a higher incidence of cardiovascular disease (CVD), certain malignancies and autoimmune disorders such as rheumatoid arthritis and Systemic Lupus Erythematosus (SLE), and renal disease. Recent studies show that reduced calorie intake and supplementation of diet with n-3 FA delays the onset of autoimmune renal disease, primarily, due to increased antioxidant enzyme activities, decreased NF-kappaB activation and decreased IL-1, IL-6 and TNF-alpha mRNA expression in the kidney tissue. Studies in rodents show that addition of n-3 FA and soy protein to diet affords protection against bone loss induced by ovariectomy in mice due to NF-kappaB expression and decreased activation of osteoclasts. Together, the available evidence show that increased daily intake of dietary n-3 FA decreases the severity of autoimmune disorders, lessens the chance of developing CVD, and protects against bone loss during post-menopause.

International Perspectives on Sexual and Reproductive Health, Dec 1, 2010

The Matlab Maternal Child Health-Family Planning (MCH-FP) project provides maternity care as part... more The Matlab Maternal Child Health-Family Planning (MCH-FP) project provides maternity care as part of its reproductive health services. It is important to assess whether this project has reduced maternal mortality and, if so, whether this was due to differences between the MCH-FP area (which received project services) and the comparison area (which did not) in pregnancy rates, pregnancy outcomes or case-fatality rates. Data from the Matlab Demographic Surveillance System on 165,894 pregnancies over the period 1982-2005 were used to calculate four measures of maternal mortality for the MCH-FP and comparison areas. Mortality risk was examined by type of pregnancy outcome and by area, and bivariate and logistic regression analyses were used to generate unadjusted and adjusted odds ratios, respectively. The maternal mortality rate of 35 deaths per 100,000 women of reproductive age in the MCH-FP area was 37% lower than that in the comparison area (56 deaths per 100,000). In both areas, the maternal mortality risk was considerably higher for pregnancies that ended in induced abortion, miscarriage or stillbirth than for those that resulted in live birth (odds ratios, 4.2, 2.0 and 17.4, respectively). The difference in maternal mortality rates between the two areas was mainly a result of the MCH-FP area's lower pregnancy rate and its lower case-fatality rates for induced abortions, miscarriages and stillbirths. Interventions to increase contraceptive use; to reduce the incidence of induced abortion, miscarriage and stillbirth; to improve the management of such outcomes; and to strengthen antenatal care could substantially reduce maternal mortality in Bangladesh and similar countries.

Http Dx Doi Org 10 1080 1369183x 2012 659129, Mar 12, 2012

... Huffman SL, Chowdhury A, Allen H, Nahar L (1987). Suckling patterns and post-partum amenorrhe... more ... Huffman SL, Chowdhury A, Allen H, Nahar L (1987). Suckling patterns and post-partum amenorrhea in Bangladesh. J. Biosoc. Sci. 19: 171-179. ... National Institute of Population Research and Training (NIPORT), Dhaka, Bangladesh. Nessa F, Rahman S, Ahmed AKMS (1987). ...

Journal of Bone and Mineral Metabolism, Apr 15, 2010

Aging is associated with bone loss, leading to increased risk of fractures. Recently, there is gr... more Aging is associated with bone loss, leading to increased risk of fractures. Recently, there is growing interest in identifying nutritional supplements that can prevent bone loss with minimum side effects. There is increasing evidence for the beneficial effects of n-3 fatty acids in the prevention of bone loss. A transgenic mouse model (fat-1) that produces n-3 fatty acids endogenously and its wild type counterpart were used in this study to determine the effects of endogenously produced n-3 fatty acids on serum bone turnover markers, long bones, and lumbar vertebrae. Serum alkaline phosphatase and P1NP levels decreased significantly in wild type mice after ovariectomy. No significant changes were seen in osteocalcin. Cancellous and cortical bone mass were higher in the femur of fat-1 mice. In wild type mice, there was significant loss of bone after ovariectomy in the distal femur, femoral neck, proximal tibia, and fourth lumbar vertebra. However, in fat-1 mice, there was no, or significantly less, bone lost after ovariectomy in all the sites studied. We conclude that endogenously produced n-3 fatty acids can attenuate ovariectomy induced bone loss in the different bone sites studied, mainly as a consequence of decreased bone resorption at the endosteal surface.